Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Abstract: A high pressure filter cap configured to withstand a high pressure differential and to minimize the deposit of residue on the filter cap threads. The body of the cap has, protruding from its lower surface, two circular flanges concentrically arranged about a central axis. The outer flange is threaded on its inner surface to engage the threads of a filter housing. The inner flange accommodates, on its outer surface, a sealing component such as an o-ring. A retainer, removably attached to the cap, holds the sealing component in place.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Abstract: A hydraulic filter includes a canister extending along the longitudinal axis. A closed end cap is at one end of the canister for closing one end thereof. A removable filter element is contained within the canister and a modular one-piece input end cap is at an end of the canister. The one-piece input end cap includes a hydraulic input chamber and a hydraulic output chamber which can be positioned in any one of three mutually perpendicular directions. The one-piece input end cap also allows for sensors to be positioned in any one of three mutually perpendicular directions. In addition, the one-piece input end cap can be utilized in base-ported or top-ported configurations while also allowing for side-to-side or side-to-end configurations.