Patents by Inventor Michael J. Smanski

Michael J. Smanski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Programmable transcription factors and methods
    Patent number: 11834665
    Abstract: This disclosure describes a programmable transcription factor system. Generally, the system includes a programmable transcription factor, a polynucleotide that includes a coding region whose expression is either required or toxic for cell viability, and a promoter operably linked to the polynucleotide and having a binding site for the programmable transcription factor. The programmable transcription factor generally includes a domain that specifically binds to a promoter and a domain that either activates transcription (if the polynucleotide encodes an essential product) or represses transcription (if the polynucleotide encodes a toxic product).
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: December 5, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Michael J. Smanski, Maciej Maselko
  • PROGRAMMABLE TRANSCRIPTION FACTORS AND METHODS
    Publication number: 20200157552
    Abstract: This disclosure describes a programmable transcription factor system. Generally, the system includes a programmable transcription factor, a polynucleotide that includes a coding region whose expression is either required or toxic for cell viability, and a promoter operably linked to the polynucleotide and having a binding site for the programmable transcription factor. The programmable transcription factor generally includes a domain that specifically binds to a promoter and a domain that either activates transcription (if the polynucleotide encodes an essential product) or represses transcription (if the polynucleotide encodes a toxic product).
    Type: Application
    Filed: May 10, 2018
    Publication date: May 21, 2020
    Inventors: Michael J. Smanski, Maciej Maselko
  • Platensimycin biosynthetic gene cluster of
    Patent number: 8652838
    Abstract: The present invention relates to the cloning and sequence of a biosynthetic gene cluster from Streptomyces platensis that produces platensimycin and platencin. Also provided are engineered micro-organisms for the production of these compounds, and analogs thereto, as well as methods of screening for compounds with anti-bacterial activity.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: February 18, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Michael J. Smanski
  • PLATENSIMYCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES PLATENSIS
    Publication number: 20090081673
    Abstract: The present invention relates to the cloning and sequence of a biosynthetic gene cluster from Streptomyces platensis that produces platensimycin and platencin. Also provided are engineered micro-organisms for the production of these compounds, and analogs thereto, as well as methods of screening for compounds with anti-bacterial activity.
    Type: Application
    Filed: July 24, 2008
    Publication date: March 26, 2009
    Inventors: BEN SHEN, Michael J. Smanski