Patents by Inventor Michael J. Smith

Michael J. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240081843
    Abstract: Systems, techniques, and devices are described that may be used in a minimally invasive bone realignment procedure. In some examples, a method of performing a minimally invasive metatarsal correction procedure involves using a bone preparation guide having a guide surface with a length less than a diameter of a bone to be cut using the guide surface. The clinician can guide a bone preparation instrument along the guide surface and angle the bone preparation instrument beyond one or both ends of the guide surface to cut the end of the underlying bone beyond one or both of the ends.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 14, 2024
    Inventors: Adriaan Kuyler, Paul Dayton, Mark Erik Easley, William T. DeCarbo, Daniel J. Hatch, Jody McAleer, Robert D. Santrock, W. Bret Smith, Sean F. Scanlan, Jason May, Michael Stedham
  • Publication number: 20230271946
    Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
    Type: Application
    Filed: April 13, 2023
    Publication date: August 31, 2023
    Inventors: Ke Chen, Joerg Deerberg, Dong Lin, Michael Dummeldinger, Bahar Inankur, Sergei Kolotuchin, Jun Li, Amanda J. Rogers, Victor W. Rosso, Eric M. Simmons, Maxime C.D. Soumeillant, Daniel S. Treitler, Jianji Wang, Bin Zheng, Michael J. Smith, Neil A. Strotman, Steven Tymonko, Tamas Benkovics
  • Publication number: 20230265050
    Abstract: The present application provides processes for synthesizing cationic lipids of Formula I useful in the synthesis of fat-soluble compositions for targeting and enhancing activity of therapeutic molecules, including siRNA.
    Type: Application
    Filed: June 22, 2021
    Publication date: August 24, 2023
    Inventors: Gregory Louis Beutner, Ronald Carrasquillo-Flores, Federico Lora Gonzalez, Michael J. Smith
  • Publication number: 20230250053
    Abstract: The present application provides processes for synthesizing targeting molecules of Formula (I) comprising a retinoid moiety useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.
    Type: Application
    Filed: June 22, 2021
    Publication date: August 10, 2023
    Inventors: Zhongping Shi, Yichen Tan, Federico Lora Gonzalez, Ronald Carrasquillo-Flores, Michael J. Smith
  • Publication number: 20230250056
    Abstract: The present application provides processes for synthesizing lipids of Formula I useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.
    Type: Application
    Filed: June 22, 2021
    Publication date: August 10, 2023
    Inventors: Gregory Louis Beutner, Federico Lora Gonzalez, Patricia Y. Cho, Michael J. Smith
  • Patent number: 11714924
    Abstract: In one embodiment, a system includes a non-volatile memory that may serve as both the main memory system and the backing store (or persistent storage). In some embodiments, the non-volatile memory is divided into a main memory portion and a persistent portion. Data in the main memory operation may be encrypted using one or more first keys, and data in the persistent portion may be encrypted using one or more second keys, in an embodiment. The volatile behavior of main memory may be implemented by discarding the one or more first keys in a power down event or other event that indicates a loss of main memory data, while the one or more second keys may be retained. In one embodiment, the physical address space of the non-volatile memory may be a mapping from a second physical address space that is used within the system.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: August 1, 2023
    Assignee: Apple Inc.
    Inventors: Manu Gulati, Joseph Sokol, Jr., Jeffrey R. Wilcox, Bernard J. Semeria, Michael J. Smith
  • Patent number: 11623013
    Abstract: Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: April 11, 2023
    Inventors: Michael J. Smith, Haiying Tang, Paul E. Morin, Harold J. Malone, Luciano Mueller
  • Publication number: 20230075422
    Abstract: The present invention provides inhibitors of fucosylation during protein expression from mammalian cells. The inhibitors are derived from rhamnose and act by inhibition of GDP-mannose 4,6-dehydratase (GMD). The invention further provides methods of making proteins with reduced level of fucosylation, such as antibodies and antibodies made by the methods of the present invention. Such hypofucosylated or nonfucosylated antibodies may find use, for example, in treatment of human disease in which is it therapeutically eneficial to direct antibody dependent cellular cytotoxicity (ADCC) mediated killing of cells expressing the antibody target on their surface, for example in depletion of Tregs in cancer patients using a hypofucosylated or nonfucosylated anti-CTLA-4 antibody.
    Type: Application
    Filed: December 18, 2020
    Publication date: March 9, 2023
    Inventors: Ping XU, Anurag Khetan, Rodney Lawrence Parsons, Michael J. Smith, Michael Anthony Schmidt
  • Publication number: 20230022450
    Abstract: Electrical, mechanical, computing, and/or other devices that include components formed of extremely low resistance (ELR) materials, including, but not limited to, modified ELR materials, layered ELR materials, and new ELR materials, are described.
    Type: Application
    Filed: March 28, 2022
    Publication date: January 26, 2023
    Inventors: Douglas J. Gilbert, Y. Eugene SHTEYN, Michael J. Smith, Joel Patrick HANNA, Paul GREENLAND, Brian COPPA, Forrest NORTH
  • Publication number: 20220361974
    Abstract: A multi-layer, super-planar laminate structure can be formed from distinctly patterned layers. The layers in the structure can include at least one rigid layer and at least one flexible layer; the rigid layer includes a plurality of rigid segments, and the flexible layer can extend between the rigid segments to serve as a joint. The layers are then stacked and bonded at selected locations to form a laminate structure with inter-layer bonds, and the laminate structure is flexed at the flexible layer between rigid segments to produce an expanded three-dimensional structure, wherein the layers are joined at the selected bonding locations and separated at other locations. A layer with electrical wiring can be included in the structure for delivering electric current to devices on or in the laminate structure.
    Type: Application
    Filed: July 18, 2022
    Publication date: November 17, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Joshua B. Gafford, Samuel B. Kesner, Conor J. Walsh, Michael Karpelson, Robert J. Wood, Zivthan Dubrovsky, Benjamin I. Goldberg, Kathleen O'Donnell, Michael J. Smith
  • Patent number: 11419693
    Abstract: A multi-layer, super-planar laminate structure can be formed from distinctly patterned layers. The layers in the structure can include at least one rigid layer and at least one flexible layer; the rigid layer includes a plurality of rigid segments, and the flexible layer can extend between the rigid segments to serve as a joint. The layers are then stacked and bonded at selected locations to form a laminate structure with inter-layer bonds, and the laminate structure is flexed at the flexible layer between rigid segments to produce an expanded three-dimensional structure, wherein the layers are joined at the selected bonding locations and separated at other locations. A layer with electrical wiring can be included in the structure for delivering electric current to devices on or in the laminate structure.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: August 23, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Joshua B. Gafford, Samuel B. Kesner, Conor J. Walsh, Michael Karpelson, Robert J. Wood, Zivthan Dubrovsky, Benjamin I. Goldberg, Kathleen O'Donnell, Michael J. Smith
  • Patent number: 11307921
    Abstract: One embodiment provides for a data processing system comprising multiple independent processors to execute multiple operating system environments of the data processing system, the multiple operating system environments to enable operation of multiple regions of a computing device associated with the data processing system. The multiple operating system environments are interconnected via a transport agnostic communication link. In response to detection of a fatal error in one or more of the multiple operating system environments, the multiple operating system environments coordinate performance of multiple separate error handling operations within the multiple operating system environments to generate a combined error log. The combined error log includes operational states of the multiple operating system environments.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: April 19, 2022
    Assignee: Apple Inc.
    Inventors: Christopher J. Noe, Joshua H. Berlin, Joseph J. Castro, Hardik K. Doshi, Joel N. Kerr, Kerry J. Kopp, Michael J. Smith
  • Patent number: 11289639
    Abstract: Electrical, mechanical, computing, and/or other devices that include components formed of extremely low resistance (ELR) materials, including, but not limited to, modified ELR materials, layered ELR materials, and new ELR materials, are described.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: March 29, 2022
    Assignee: Ambature, Inc.
    Inventors: Douglas J. Gilbert, Y. Eugene Shteyn, Michael J. Smith, Joel Patrick Hanna, Paul Greenland, Brian Coppa, Forrest North
  • Publication number: 20220058292
    Abstract: In one embodiment, a system includes a non-volatile memory that may serve as both the main memory system and the backing store (or persistent storage). In some embodiments, the non-volatile memory is divided into a main memory portion and a persistent portion. Data in the main memory operation may be encrypted using one or more first keys, and data in the persistent portion may be encrypted using one or more second keys, in an embodiment. The volatile behavior of main memory may be implemented by discarding the one or more first keys in a power down event or other event that indicates a loss of main memory data, while the one or more second keys may be retained. In one embodiment, the physical address space of the non-volatile memory may be a mapping from a second physical address space that is used within the system.
    Type: Application
    Filed: September 8, 2021
    Publication date: February 24, 2022
    Inventors: Manu Gulati, Joseph Sokol, JR., Jeffrey R. Wilcox, Bernard J. Semeria, Michael J. Smith
  • Patent number: 11219853
    Abstract: A negative air filtration system and a method of operating a negative air filtration system are provided. The negative air filtration system includes a housing, a pre-filter, a HEPA filter, and a fan assembly. The housing including an inlet and an outlet. The pre-filter is disposed within the housing, downstream of the inlet. The HEPA filter is disposed within the housing, downstream of the pre-filter. The fan assembly is disposed within the housing, downstream of the pre-filter. The fan assembly is in airflow communication with the pre-filter and the HEPA filter. The fan assembly is configured to generate a negative pressure across the pre-filter. The fan assembly may include a constant torque motor. The negative air filtration system is designed to have reduced complexity and increased reliability when compared to existing negative air filtration systems.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: January 11, 2022
    Assignee: Carrier Corporation
    Inventors: Kevin Mercer, Michael J. Smith
  • Publication number: 20210316243
    Abstract: A negative air filtration system and a method of operating a negative air filtration system are provided. The negative air filtration system includes a housing, a pre-filter, a HEPA filter, and a fan assembly. The housing including an inlet and an outlet. The pre-filter is disposed within the housing, downstream of the inlet. The HEPA filter is disposed within the housing, downstream of the pre-filter. The fan assembly is disposed within the housing, downstream of the HEPA filter. The fan assembly is in airflow communication with the pre-filter and the HEPA filter. The fan assembly is configured to generate a negative pressure across the pre-filter and the HEPA filter. The fan assembly may include a constant torque motor. The negative air filtration system is designed to have reduced complexity and increased reliability when compared to existing negative air filtration systems.
    Type: Application
    Filed: March 9, 2021
    Publication date: October 14, 2021
    Inventors: Kevin Mercer, Michael J. Smith
  • Patent number: 11138346
    Abstract: In one embodiment, a system includes a non-volatile memory that may serve as both the main memory system and the backing store (or persistent storage). In some embodiments, the non-volatile memory is divided into a main memory portion and a persistent portion. Data in the main memory operation may be encrypted using one or more first keys, and data in the persistent portion may be encrypted using one or more second keys, in an embodiment. The volatile behavior of main memory may be implemented by discarding the one or more first keys in a power down event or other event that indicates a loss of main memory data, while the one or more second keys may be retained. In one embodiment, the physical address space of the non-volatile memory may be a mapping from a second physical address space that is used within the system.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: October 5, 2021
    Assignee: Apple Inc.
    Inventors: Manu Gulati, Joseph Sokol, Jr., Jeffrey R. Wilcox, Bernard J. Semeria, Michael J. Smith
  • Publication number: 20210117265
    Abstract: One embodiment provides for a data processing system comprising multiple independent processors to execute multiple operating system environments of the data processing system, the multiple operating system environments to enable operation of multiple regions of a computing device associated with the data processing system. The multiple operating system environments are interconnected via a transport agnostic communication link. In response to detection of a fatal error in one or more of the multiple operating system environments, the multiple operating system environments coordinate performance of multiple separate error handling operations within the multiple operating system environments to generate a combined error log. The combined error log includes operational states of the multiple operating system environments.
    Type: Application
    Filed: December 7, 2020
    Publication date: April 22, 2021
    Inventors: Christopher J. Noe, Joshua H. Berlin, Joseph J. Castro, Hardik K. Doshi, Joel N. Kerr, Kerry J. Kopp, Michael J. Smith
  • Publication number: 20210107897
    Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 15, 2021
    Inventors: Ke Chen, Joerg Deerberg, Dong Lin, Michael Dummeldinger, Bahar Inankur, Sergei Kolotuchin, Jun Li, Amanda J. Rogers, Victor W. Rosso, Eric M. Simmons, Maxime C.D. Soumeillant, Daniel S. Treitler, Jianji Wang, Bin Zheng, Michael J. Smith, Neil A. Strotman, Steven Tymonko, Tamas Benkovics
  • Patent number: 10977799
    Abstract: A system and method for automatically changing the operation of a mobile device in response to a presence of information is described. In some examples, the system determines an information capture device is proximate to text, automatically changes operation of the capture device to a certain mode, captures the text, and performs an action associated with the captured text.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: April 13, 2021
    Assignee: Google LLC
    Inventors: Martin T. King, Redwood Stephens, Claes-Fredrik Mannby, Jesse Peterson, Mark Sanvitale, Michael J. Smith