Abstract: Tamper-respondent assemblies are provided which include individualized fluid chemical mixtures for tamper detection. The tamper-respondent assemblies include, for instance, a circuit board and an enclosure. The circuit board includes an electronic component, and the enclosure is mounted to the circuit board to enclose the electronic component within a secure volume, where the secure volume is a sealed space. A fluid is disposed within the secure volume that includes a chemical mixture of multiple chemical substances, and the multiple chemical substances have randomly generated concentrations within the chemical mixture. One or more sensors are provided to facilitate detecting a change in the chemical mixture of the fluid within the secure volume indicative of a tamper event.

Abstract: A faucet for dispensing a fluid includes a spout, a pull-out spray head removably coupled to the spout and including an outlet, and a valve assembly in fluid communication with the outlet. Additionally, the faucet includes a fluid treatment assembly configured to output a treatment into the fluid.

Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.

Abstract: A flangeless fluid end comprising a fluid end body releasably attached to a connect plate. The connect plate is attached to a power source using stay rods. The flow bores of the fluid end are sealed without threading a retainer nut into the walls of each bore. Instead, the flow bores are sealed by bolting a retainer to the fluid end body. Plungers to drive fluid through the fluid end body are installed within removable stuffing box sleeves. These sleeves are maintained within the plunger bores by the bolted retainers. A number of features, including the location of seals within bore walls and carbide inserts within valve structures, aid in reducing or transferring wear.

Abstract: A power end assembly includes a crankshaft section, a crosshead section, and a connector section coupled together by one, two, or more sets of stay rods. The power end may include one or more support plates that are coupled to the crankshaft section and/or crosshead section. The crosshead section includes a plurality of individual crosshead frames. The connector section may include a plurality of individual connector plates or may be a unitary connector plate. The power end is configured to be coupled to a fluid end assembly by coupling the fluid end assembly to the connector plates.

Abstract: A fluid end assembly comprising a housing having multiple conduits formed therein. A tubular sleeve is installed within one of the conduits and is configured to house a plurality of packing seals. A seal is installed within a groove formed in the walls of the housing surrounding the tubular sleeve such that the seal engages an outer surface of the tubular sleeve.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis in said subject. Systems and methods are also described.

Abstract: The present invention pertains to the field of medical diathermy and addresses issues of incidental undesired radiation in the prior art. The invention uses a multitude of pairs of intentional radiators with each pair driven with an identical but out-of-phase signal. The pairs or radiators are spaced near the target tissue in close proximity to the target but sufficiently distant from each other so as not to cancel the nearby tissue heating effects. Local heating of tissue is achieved by the high electric and magnetic field intensities coupling and inducing electric currents in conductive tissue.

Abstract: A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis in said subject. Systems and methods are also described.

Abstract: A method of measuring an amount of at least one cholesteryl ester in a blood sample is carried out by combining a blood sample with a salt and an alcohol to provide a dilute sample; introducing the dilute sample into a mass spectrometer; and then measuring the amount of the at least one cholesteryl ester in the dilute sample by mass spectrometry, to thereby measure the amount of at least one cholesteryl ester in the blood sample, is described.

Abstract: A tailored vehicle seat component 12 having at least two portions with different properties that are joined together, such as by an adhesive or in a welding process (e.g., laser weld). These different properties include thickness, grades, surface finishes, coatings, and the like. The laser tailored welded vehicle seat 12 components may be incorporated into seat back frames 16, seat track assemblies 26, recliners 20, seat base frames 18, head restraints 88, cushion pans 132, and the like, to optimize manufacturing operations, mass, performance quality, and costs.

Abstract: A tailored vehicle seat component 12 having at least two portions with different properties that are joined together, such as by an adhesive or in a welding process (e.g., laser weld). These different properties include thickness, grades, surface finishes, coatings, and the like. The laser tailored welded vehicle seat 12 components may be incorporated into seat back frames 16, seat track assemblies 26, recliners 20, seat base frames 18, head restraints 88, cushion pans 132, and the like, to optimize manufacturing operations, mass, performance quality, and costs.

Abstract: A composite material for reinforcing closed structural members as a tube or any closed profile section. More specifically, a composite material for filling metal tubes or any closed profile section forming the frame of vehicle seats to increase or maintain the strength of the seat frame while reducing the mass of the seat tubes or sealed profile section.

Abstract: A viewer is disclosed for viewing a multi-dimensional data set. The viewer may be coupled to or included in a test environment and receive data generated in the test environment. The test environment may generate metric data from the multiple test cases of a UUT. The viewer may display the cumulative metric data generated from multiple test cases. The viewer may display the cumulative metric data in a fashion that the user can gain insight into the UUT's characteristics.

Abstract: A foam reinforced and bent tube for use in a vehicle seat frame and a method of forming such a tube are provided. The tube has a cavity which extends along its length and at least one open end. The foam may be inserted into the cavity through any desirable process including, for example, injection. The bend is formed by heating a portion of the tubular element and bending it at the heated region. The insertion of the foam material into the cavity of the tubular element may precede, follow or be simultaneous with the heating and bending processes. The foam material may have a variable type and/or a variable density through the length of the cavity.

Abstract: A tailored vehicle seat component 12 having at least two portions with different properties that are joined together, such as by an adhesive or in a welding process (e.g., laser weld). These different properties include thickness, grades, surface finishes, coatings, and the like. The laser tailored welded vehicle seat 12 components may be incorporated into seat back frames 16, seat track assemblies 26, recliners 20, seat base frames 18, head restraints 88, cushion pans 132, and the like, to optimize manufacturing operations, mass, performance quality, and costs.

Abstract: A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis blood sample by mass spectrometry.

Abstract: Generating cumulative metric data for a test in a test environment includes: generating in the test environment a test for a simulation model of a system under test; generating in the test environment at least one test condition for the test, the at least one test condition determining a plurality of iterations of the simulation model; generating in the test environment at least one temporary test variable for the test; generating in the test environment at least one mapping between a metric setting for the simulation model and one of the temporary test variables; running in the test environment the test for the plurality of iterations, wherein metric data for the simulation model is generated for each mapping and for each iteration of the test; and accumulating in the test environment the generated metric data for each mapping and for each iteration of the test to obtain cumulative metric data for the simulation model.

Abstract: In a user-interactive system, such as an interactive voice response (IVR) system, the duration and/or force of key-presses by the user and/or the speed of response to prompts by the user are used to make inferences about the user, such as whether the user is impaired or is growing frustrated. The user interface is modified based on the inferences.