Patents by Inventor Michael J. Tolentino

Michael J. Tolentino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA
    Publication number: 20090191263
    Abstract: RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
    Type: Application
    Filed: January 26, 2009
    Publication date: July 30, 2009
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Samuel Jotham Reich, Enrico Maria Surace, Michael J. Tolentino
  • COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1
    Publication number: 20090104260
    Abstract: RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Application
    Filed: December 5, 2008
    Publication date: April 23, 2009
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Samuel Jotham Reich, Michael J. Tolentino
  • COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS
    Publication number: 20090104259
    Abstract: RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Application
    Filed: December 4, 2008
    Publication date: April 23, 2009
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Michael J. Tolentino, Samuel Jotham Reich
  • Compositions and methods for siRNA inhibition of HIF-1 alpha
    Patent number: 7521431
    Abstract: RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: April 21, 2009
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Samuel Jotham Reich, Enrico Maria Surace, Michael J. Tolentino
  • Compositions and Methods for siRNA Inhibition of Angiogenesis
    Publication number: 20080188437
    Abstract: RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Application
    Filed: March 6, 2008
    Publication date: August 7, 2008
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Michael J. Tolentino, Samuel Jotham Reich
  • Compositions and methods for siRNA inhibition of angiogenesis
    Patent number: 7345027
    Abstract: RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involved angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: March 18, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Michael J. Tolentino, Samuel Jotham Reich
  • Compositions and methods for sirna inhibition of angiogenesis
    Patent number: 7148342
    Abstract: RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: December 12, 2006
    Assignee: The Trustees of the University of Pennyslvania
    Inventors: Michael J. Tolentino, Samuel Jotham Reich
  • Compositions and methods for siRNA inhibition of angiopoietin 1and 2 and their receptor Tie2
    Publication number: 20040248174
    Abstract: RNA interference using small interfering RNAs which are specific for mRNA produced from the Ang1, Ang2 or Tie2 genes inhibits expression of these genes. Diseases which involve Ang1, Ang2 or Tie2 mediated angiogenesis, such as inflammatory and autoimmune diseases, diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Application
    Filed: April 19, 2004
    Publication date: December 9, 2004
    Applicant: TheTrustees of the University of Pennsylvania
    Inventors: Samuel Jotham Reich, Michael J. Tolentino
  • Compositions and methods for siRNA inhibition of ICAM-1
    Publication number: 20040220129
    Abstract: RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Application
    Filed: January 16, 2004
    Publication date: November 4, 2004
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Samuel Jotham Reich, Michael J. Tolentino
  • Compositions and methods for siRNA inhibition of HIF-1 alpha
    Publication number: 20040180357
    Abstract: RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
    Type: Application
    Filed: October 31, 2003
    Publication date: September 16, 2004
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Samuel Jotham Reich, Enrico Maria Surace, Michael J. Tolentino
  • Compositions and methods for siRNA inhibition of angiogenesis
    Publication number: 20040018176
    Abstract: RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
    Type: Application
    Filed: November 14, 2002
    Publication date: January 29, 2004
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Michael J. Tolentino, Samuel Jotham Reich