Abstract: Broad spectrum antiparasitic agents of formula (I) having utility as anthelmintics, ectoparasiticides, insecticides, acaricides and animal growth promotants ##STR1## wherein Y is a single bond or a double bond; R.sup.1 is OH; provided that when Y is a single bond R.sup.1 is present and when Y is a double bond R.sup.1 is absent; R.sup.2 is .dbd.CH.sub.2 or a group of the formula --(X)--C(R.sup.5).dbd.CHR.sup.6 ; R.sup.3 is H or CH.sub.3 ; R.sup.5 and R.sup.6 are both H; R.sup.5 is H and R.sup.6 is C.sub.1 -C.sub.3 alkyl; or one of R.sup.5 and R.sup.6 is H and the other is C.sub.2 -C.sub.6 alkoxycarbonyl, phenyl, substituted phenyl, heteroaryl or substituted heteroaryl; and X is a direct bond or an alkylene group having from 2 to 6 carbon atoms which may be straight or branched-chain; with the proviso that R.sup.5 and R.sup.6 are not both hydrogen when X is --CH(CH.sub.3)CH.sub.2 --; processes and intermediates therefor, and compositions thereof.

Abstract: Antiparasitics comprising Avermectin derivatives of formula (I): ##STR1## wherein X represents a single or a double bond; R.sup.1 is H or OH; provided that when X is a single bond, R.sup.1 is H or OH, and when X is a double bond, R.sup.1 is absent;R.sup.2 is an alkyl group substituted by one oxo or one or more hydroxy groups or by a single oxygen atom on two adjacent carbon atoms to form an oxirane ring, or R.sup.2 is an alkyl group substituted by an alkoxycarbonyl group, said substituents on R.sub.2 being attached to either or both a terminal carbon atom and a carbon atom adjacent to a terminal carbon atom of R.sup.2 ; and R.sup.3 is H or CH.sub.3 ; or, when R.sup.2 is oxo-substituted alkyl, an alkyl acetal or ketal derivative thereof.

Abstract: 6-Fluoro-7-pyridylquinolone carboxylic esters and acids having antibacterial activity are prepared by coupling of a 2-fluorophenyl-metallic compound with a pyridyl bromide or iodide in the presence of a transition metal catalyst, nitrating and hydrogenating the pyridyl-2-fluorophenyl compound formed, introducing a substituent on the nitrogen of the amine formed, and cyclizing after reacting with a dialkyl or dibenzyl ethoxymethylene malonate to form a 6-fluoro-7-pyridyl-1,4-dihydroquinol-4-one 3-carboxylate, and hydrolyzing to the corresponding acid.

Abstract: 1-Alkyl-6,8-difluoro-7-heterocyclic-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by conventional cyclization methods.

Abstract: 1-Substituted-6-fluoro-7-aryl-(8-fluoro)-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by reacting the corresponding alkyl 1-substituted-6-fluoro-7-bromo-(8-fluoro)-1,4-dihydroquinol-4-one-3-carbox ylate with an arylmetallic compound and hydrolyzing the ester formed.

Abstract: L-pyroglutamyl-pyridylalanyl-L-prolinamides of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl or aryl; and X is H, halo, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; and their physiologically acceptable salts and feed compositions thereof are useful for improving the efficiency of feed utilization and/or growth of animals especially poultry.