Abstract: A computing system can obtain, through one or more sensor systems onboard an autonomous vehicle, a motion input, a surface element registration input representing one or more tracked surface elements, and a lane alignment input representing one or more lane boundaries. The computing system can provide the motion input, the surface element registration input, and the lane alignment input to a pose estimation system including a localization filter. The pose estimation system can generate one or more pose states of the autonomous vehicle, including a local pose and a global pose. The computing system can determine a motion plan for the autonomous vehicle based on the one or more pose states.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a TREM2 protein, e.g., human TREM2, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: A snow and ice control spreader and sprayer comprises a granular material hopper, a granular material delivery system, at least first and second liquid tanks mounted on both sides of the hopper, the first tank having a first volume and the second tank having a second volume, the first volume being greater than the second volume, a liquid delivery system, and a manifold.

Abstract: The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.

Abstract: Disclosed are plasticizer compositions in the form of crop-based secondary amines prepared through catalyzed reductive amination (RA) of furans with aminated ketones. Exemplary furans include, but are not limited to, furfural, 5-(hydroxymethyl) furfural (HMF), and 2,5-diformylfuran (DFF). These furans may be crop-based. Furfural, for example, may be made through dehydration of xylose isolated from corn cobs. Exemplary aminated ketones include, but are not limited to, crop-based aminated ketones such as 2-aminoundecane. For example, 2-aminoundecane may be prepared through catalyzed RA of 2-undecanone from the seed oil of Cuphea. These RA reactions may be catalyzed using, for example, Pd/C. In some embodiments, the plasticizer compositions function as plasticizers when blended with polyvinylchloride (PVC) and/or other polymers to form plasticized compositions. Processes for making the plasticizer compositions and plasticized compositions are also disclosed.

Abstract: A method is implemented by a system including a processor and a memory storing processor executable code for a customization engine is provided. The customization engine generates a customer specific insurance application specific to a first user and provides access to the first user based on an invitation. The invitation include a unique customer link to the customer specific insurance application. The invitation is initiated by an input from a second user. The customization engine dynamically builds and fills-in the customer specific insurance application based on inputs from the first user and on automatically populating customer specific insurance application with non-standardized data to provide a completed customer specific insurance application. The customization engine provides a customized insurance request based on the completed customer specific insurance application to a third user and facilitates insurance coverage from the third user for the first user based on the customized insurance request.

Abstract: In one embodiment, an apparatus for dispensing a liquid is disclosed. The apparatus can comprise a cap configured to connect to a container body having a chamber for containing the liquid. The cap can comprise a pour aperture through which the liquid exits the apparatus. The cap can comprise a pour lid configured to open and close the pour aperture. The cap can comprise a cap vent configured to allow air to flow from the outside environs into the chamber of the container body when the cap is connected to the container body.

Abstract: Suture passer systems for tissue suspension and tissue compression, and more particularly for tongue suspension, are described. The system can include at least a first elongate tubular body or shaft, a needle having a lateral bias carried by the elongate body, and a retrieval element operably connected to the elongate tubular body. The needle can have a substantially straight configuration when located within the elongate tubular body, and be configured to exit an opening at or near a distal end of the elongate tubular body and assume a laterally biased or curved shape to form a path through tissue. The needle is configured to carry a suture. The retrieval element can be configured to retrieve the suture carried by the needle after the needle has formed a curved or otherwise angled path through tissue. The system can also include one or more bone anchors to secure the suture loops. Methods of placing one or more suture loops into tissue, such as the base of the tongue, are also described.

Abstract: CT system including: an X-ray source and an X-ray detector arranged opposite the X-ray source, wherein the X-ray detector and the X-ray source may be mutually rotated around at least one rotation center through a rotator, wherein the distances between the at least one rotation center and the X-ray source and between the at least one rotation center and the X-ray detector are different.

Abstract: The present invention relates to a disposable safety glove system featuring a plurality of layers of inter-nested gloves that are worn simultaneously by a user. The improved disposable glove system of the present invention allows a user to peel away the outermost layer of gloves to reveal a new and sterile set of gloves. The glove system also features a relatively thick wristband to support the plurality of glove layers, a tab that can be used to easily peel off the outermost glove layer once the same has been used and a new pair of gloves is desired, and a numbering system that alerts the user to how many glove layers remain in the glove stack.

Abstract: Methods and systems are provided for assisting operation of a vehicle to satisfy a downpath energy constraint when a current energy state has deviated from a reference energy state according to a planned route of travel. One method involves identifying an intermediate energy constraint at an intermediate point en route to the downpath waypoint, determining a first segment for satisfying the intermediate energy constraint at the intermediate point from the current energy state using a first configuration, determining a second segment from the intermediate point that satisfies the requested energy constraint at the downpath waypoint using a different configuration, and providing graphical indicia of the recommended path including the first and second segments. The graphical indicia includes a first graphical indication of the first configuration associated with the first segment and a second graphical indication of the second configuration associated with the second segment.

Abstract: A material handling apparatus and a process for feed indexing. The process for feed indexing and processing of elongated stock includes the steps of gripping and moving an elongated stock with a first shuttle vise at a desired travel velocity toward a first final position. An open second vise accelerates from a second home start position until reaching the desired travel velocity. The second vise grips and moves the stock once the second vise is at the desired travel velocity while the first vise is gripping the stock. The first vise releases the stock and recycles to a first home position while the second vise moves the stock.

Abstract: The disclosure provides stable aqueous formulations comprising an antibiotic and sodium deoxycholate (DOC), and optionally further comprising at least one carrier and/or excipient. The disclosure also provides methods for preparing such aqueous formulations, and methods for using such aqueous formulations to treat, attenuate, or prevent bacterial infection in a subject.

Abstract: A computer implemented method of monitoring the cleanliness of an underwater surface of a stationary object. The method is performed on a computing device and comprises: retrieving environmental data from memory of the computing device, the environmental data associated with environment conditions of the stationary object; determining a fouling value indicative of a level of fouling that the surface is exposed to based on at least the environmental data; determining a fouling protection value defining a tolerance to fouling associated with a surface of the stationary object; and identifying a level of risk of fouling on the surface of the stationary object by determining a fouling risk value using the fouling protection value and the fouling value.

Abstract: A computer implemented method of dynamically monitoring the cleanliness of a hull of a vessel during a journey of said vessel. The method is performed on a computing device and comprises: retrieving environmental data from memory of the computing device, the environmental data associated with environment conditions of the vessel; determining a fouling protection value defining a tolerance to fouling associated with a surface of the vessel; and identifying a level of risk of fouling on the surface of the vessel based on the fouling protection value and the environment conditions.

Abstract: A system and method of irrigation control calculates a predicted soil moisture value based that is compared to low moisture threshold. If the predicted soil moisture value is a value below the low moisture threshold value, the next irrigation cycle or scheduled irrigation operation is allowed to proceed or otherwise activated. The predicted soil moisture value may be calculated by adjusting a current soil moisture value by a historical adjustment factor based on negative net changes in soil moisture values.