Patents by Inventor Michael James Cope
Michael James Cope has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190169342Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: February 8, 2019Publication date: June 6, 2019Inventors: Inez Lees, Kalpesh Biyani, Eric Connor, Scott Hecker, Hongmin Zhang, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
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Patent number: 10272103Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: GrantFiled: October 30, 2015Date of Patent: April 30, 2019Assignee: Relypsa, Inc.Inventors: Jordan Kopping, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Kalpesh Biyani, Eric Connor, Scott Hecker, Inez Lees, Grace May, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter
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Publication number: 20170258825Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: May 22, 2017Publication date: September 14, 2017Inventors: Eric Connor, Kalpesh Biyani, Scott Hecker, Inez Lees, Paul Mansky, YongQi Mu, Faleh Salaymeh, Hongmin Zhang, David E. Bergbreiter, Grace Huynh, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
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Patent number: 9655920Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: GrantFiled: February 24, 2011Date of Patent: May 23, 2017Assignee: Relypsa, Inc.Inventors: Eric Connor, Kalpesh Biyani, Scott Hecker, Inez Lees, Paul Mansky, YongQi Mu, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Grace Huynh, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
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Publication number: 20160051576Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: October 30, 2015Publication date: February 25, 2016Applicant: RELYPSA, INC.Inventors: Jordan Kopping, Kalpesh Biyani, Eric Connor, Scott Hecker, Inez Lees, Grace Huynh, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao
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Patent number: 9181364Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: GrantFiled: February 24, 2011Date of Patent: November 10, 2015Assignee: Relypsa, Inc.Inventors: Jordan Kopping, Kalpesh Biyani, Eric Connor, Scott Hecker, Inez Lees, Grace Huynh, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao
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Publication number: 20140356316Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: February 24, 2011Publication date: December 4, 2014Applicant: RELYPSA, INC.Inventors: Eric Connor, Kalpesh Biyani, Scott Hecker, Inez Lees, Grace Huynh, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
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Publication number: 20130189215Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: February 24, 2011Publication date: July 25, 2013Applicant: RELYPSA, INC.Inventors: Inez Lees, Kalpesh Biyani, Eric Connor, Scott Hecker, Hongmin Zhang, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
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Publication number: 20130022570Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: February 24, 2011Publication date: January 24, 2013Applicant: RELYPSA, INC.Inventors: Jordan Kopping, Kalpesh Biyani, Eric Connor, Scott Hecker, Inez Lees, Grace Quaker, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao
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Patent number: 7854924Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.Type: GrantFiled: March 30, 2004Date of Patent: December 21, 2010Assignee: Relypsa, Inc.Inventors: Robert Alpern, Jerry Buysse, Han Ting Chang, Dominique Charmot, Michael James Cope, John Fordtran, Gerrit Klaerner, Eric Connor, Mingjun Liu, Futian Liu, Jun Shao
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Patent number: 7776319Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.Type: GrantFiled: March 30, 2005Date of Patent: August 17, 2010Assignee: Relypsa, Inc.Inventors: Robert Alpern, Jerry Buysse, Han Ting Chang, Dominique Charmot, Michael James Cope, John Fordtran, Gerrit Klaerner, Eric Connor, Mingjun Liu, Futian Liu, Jun Shao
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Patent number: 7666898Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.Type: GrantFiled: November 3, 2006Date of Patent: February 23, 2010Assignee: Ilypsa, Inc.Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Damien Cartigny, Shiah-yun Chen, Jerry M. Buysse
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Publication number: 20090318492Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.Type: ApplicationFiled: November 3, 2006Publication date: December 24, 2009Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Shiah-yun Chen, Jerry M. Buysse
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Publication number: 20090306171Abstract: Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R4 being a moiety represented by formula (C4-II-C), R3 being a moiety represented by formula (C3-I or C3-II).Type: ApplicationFiled: November 3, 2006Publication date: December 10, 2009Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Shiah-yun Chen, Jerry M. Buysse
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Publication number: 20090239896Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds include azaindoles of the formula below [insert FIG. 6c] in which at least one of CR4, CR5, CR6 and CR7 is replaced by N, and the groups R1-R7 are defined as in claim 1.Type: ApplicationFiled: November 3, 2006Publication date: September 24, 2009Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Tony Kwok-Kong Mong, Shiah-yun Chen, Jerry M. Buysse
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Patent number: 7488495Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.Type: GrantFiled: October 13, 2004Date of Patent: February 10, 2009Assignee: Relypsa, Inc.Inventors: Dominique Charmot, Han Ting Chang, Gerrit Klaerner, Michael James Cope, Mingjun Liu, Futian Liu, Jerry Buysse, Eric Connor, Tony Kwok-Kong Mong, Jun Shao, Deidre Madsen