Abstract: A syringe needle de-capping and re-capping device that includes a cylindrical body with a finger gripping member integrally formed thereon. Formed inside the body is a cylindrical-shaped cavity designed to receive a bushing. Formed along the upper edge of the cavity are internal threads that connect to external threads located on a removable cap that removeably attaches the cap to the body. Attached to the cap is a neck that extends into the bushing. Formed inside the bushing is a center cavity with a spring nut disposed therein designed to receive and partially engage the tip of the needle cap when inserted through the cap and into the cavity. When properly assembled, the neck on the cap holds the spring nut inside the bushing. During use, the device is held between the user's fingers with the body extending above the user's fingers so that the user may used his or her palm to hold the vial. The opposite hand holds the syringe so that needle cap may be easily de-cap and re-cap the needle.