Abstract: Systems and methods are disclosed for aiding physicians and other healthcare workers in setting prescriptions of therapeutic and/or preventive regimens. In certain embodiments the invention compares patient genotype, phenotype, proteomic, molecular, and/or other profile information with a database of information that associates third party profiles with third party responses to therapeutic and preventive regimens. The comparison information may be used by a physician or other healthcare provider to identify potential safety and/or efficacy effects of a prescribed regimen if undertaken by the patient. The systems and methods provide for the secure storage and directed access of the patient profiles.