Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A microelectromechanical systems (MEMS) sensor, a capacitive MEMS motor sensing circuit and a method are provided. The present application provides a microelectromechanical systems (MEMS) sensor. The MEMS sensor includes a housing having electrical contacts disposed on an exterior of the housing. The MEMS sensor further includes a capacitive MEMS motor disposed in the housing, and an electrical circuit disposed in the housing and being electrically coupled to the electrical contacts. The electrical circuit includes a bias voltage source having an output coupled to an input of the MEMS motor. The electrical circuit further includes a buffer circuit including an amplifier input stage having an input coupled to an output of the MEMS motor.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: This disclosure relates generally to Neisseria surface moieties. More particularly, the present disclosure relates to oligosaccharides corresponding to Neisseria lipooligosaccharides and to chimeric molecules comprising these moieties for eliciting an immune response to Neisseria organisms and/or for treating or inhibiting the development of Neisseria infections.

Abstract: The instant disclosure provides antibodies that specifically bind to CD73 (e.g., human CD73) and antagonize CD73 function. Also provided are anti-CD73 antibodies that further comprise a TGF?-binding moiety or a VEGF-binding moiety. The instant disclosure additionally provides pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to CD73 (e.g., human CD73) and antagonize CD73 function. Also provided are anti-CD73 antibodies that further comprise a TGF?-binding moiety or a VEGF-binding moiety. The instant disclosure additionally provides pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A sensor assembly including a capacitive sensor, like a microelectromechanical (MEMS) microphone, and an electrical circuit therefor are disclosed. The electrical circuit includes a first transistor having an input gate connectable to the capacitive sensor, a second transistor having an input gate coupled to an output of the first transistor, a feedforward circuit interconnecting a back-gate of the second transistor and the output of the first transistor, and a filter circuit interconnecting the output of the first transistor and the input gate of the second transistor.

Abstract: This invention relates generally to polynucleotides, polypeptides, compositions, methods and uses for eliciting an immune response to Neisseria, methods for immunizing a subject against a Neisseria infection, and methods for preventing and/or treating a Neisseria infection in a subject. More particularly, the invention relates to antigenic Neisseria polypeptides and encoding polynucleotides, and related uses and methods, including use for preparing compositions and medicaments for eliciting an immune response to Neisseria, for immunizing a subject against a Neisseria infection, and for preventing and/or treating a Neisseria infection in a subject. The invention also relates to methods for producing therapeutic anti-Neisseria antigen-binding molecules, and therapeutic uses of those antigen-binding molecules.

Abstract: A sensor assembly including a capacitive sensor, like a microelectromechanical (MEMS) microphone, and an electrical circuit therefor are disclosed. The electrical circuit includes a first transistor having an input gate connectable to the capacitive sensor, a second transistor having an input gate coupled to an output of the first transistor, a feedforward circuit interconnecting a back-gate of the second transistor and the output of the first transistor, and a filter circuit interconnecting the output of the first transistor and the input gate of the second transistor.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: An online system server determines changes in employment stages for the employees of an organization, where the organization may have multiple employees. The online system server may store employee record in an employment history database, and implement an employment history database schema facilitate the determination of the employment movement. The employment history database schema may define that the rows of an employee history database table includes pointers, where the pointers indicate a prior employer or a subsequent employer. Using formulated queries with the employment history database schema, the online system server allows an organization to more accurately log the changes in employment stages for the employees of the organization.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A water production system is provided that uses ambient air, a desiccant, a refrigeration cycle, and heat generated by the refrigeration cycle to generate water that may be used when water is scarce, for example during a natural disaster recovery operation. The system may use commercial electrical power in one embodiment, but when commercial electrical power is unavailable, it may rely on generator power. When it relies on generator power, the system may use excess heat exhausted by the generator to heat ambient air prior to its introduction to the desiccant.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Described herein are techniques for generating for each company in a set of companies a rating score that represents the desirability of employment with the company. The rating score for each company is derived by analyzing the member profiles of members of an online system to identify employee transitions between companies over certain time periods. At the beginning of a first time period, each company is assigned a baseline score. Each transition represents an employee departure (loss), for one company, and an employee hire (win), for the other company. With each transition by an employee to/from a company, the rating score of the impacted companies are adjusted—increased for a win, decreased for a loss—in some proportion that is relative to the current rating scores of the impacted companies. Accordingly, company A hires an employee from Company B, the rating scores of companies A and. B will impact the level of the adjustment that is made to their respective rating scores as a result of the transition.

Abstract: A device may perform a first authentication operation, associated with a contactless media device, using a first key. The first key may permit a security mode of the contactless media device to be modified. The device may cause the contactless media device to set the security mode to a first security mode that causes the contactless media device to secure at least one transmission from the contactless media device. The device may perform a second authentication operation, associated with the contactless media device, using a second key that permits information to be read from or written to the contactless media device. The device may read first secured information from or write second secured information to the contactless media device. The first secured information or the second secured information may be secured based on the security mode of the contactless media device being set to the first security mode.

Abstract: A microphone circuit having an amplifier with an input operably coupled to a microphone motor also includes a low pass filter operably coupled to the output of the amplifier and a positive feedback network that operably couples to an output of the low-pass filter and to the amplifier input. For many useful application settings the aforementioned amplifier has unity gain while the positive feedback network has a fractional gain less than unity.

Abstract: Methods, systems, and computer programs are presented for determining the employment type of online-service members and the generation of employment reports. One method includes training a machine learning program (MLP) for categorizing employment type, for title and company, as field or full-time-corporate. The full-time-corporate category is for full-time corporate employees. For each employee title in a first company, the method includes accessing data for members of an online service having the title and employed by the first company, and determining, by the trained MLP, the employment type for the title and the first company based on the accessed data. Further, the method includes operations for providing a user interface for generating an employment report for the first company, the user interface including one or more options for filtering data based on the employment type, and for presenting the employment report on the user interface.