Abstract: A binaural hearing system comprises first and second hearing aids, each comprising antenna and transceiver circuitry allowing the exchange of audio signals between them and a BTE-part adapted for being located at or behind the external ear (pinna) of the user and comprising front and rear input transducers providing respective front and rear electric input signals. Each of the hearing aids comprises primary and secondary adaptive 2-channel beamformers each providing a spatially filtered signal based on first and second beamformer-input signals. The primary and secondary 2-channel beamformers are coupled in a cascaded structure. The inputs to the primary 2-channel beamformers are, locally generated, front and rear electric input signals. The inputs to the secondary 2-channel beamformer may be beamformed signals from the first and second hearing aids respectively. The spatially filtered signal of the secondary 2-channel beamformer may comprise an estimate of a target signal in the environment of the user.

Abstract: Systems and methods for improved intelligent manipulation of distributed-denial-of-service (DDoS) attack traffic are provided. In implementations, a method may include receiving, at a traffic management system, a mirrored first stream of packets from a router on a first link and a mirrored second stream of packets from the router on a second link. The method may further include determining flow information about the first stream. In examples, the flow information may indicate that a challenge to a particular source IP address has been issued to test the legitimacy of the source IP address. The method may further include sending, by the traffic management system, a routing policy update based on the flow information.

Abstract: A hearing device, e.g. a hearing aid, comprises a) at least one input transducer for converting sound in the environment of the hearing device to respective at least one acoustically received electric input signal or signals representing said sound; b) a wireless receiver for receiving an audio signal from a wireless transmitter of a sound capturing device for picking up sound in said environment and providing a wirelessly received electric input signal representing said sound; and c) a processor configured c1) to receive said at least one acoustically received electric input signal or signals, or a processed version thereof; c2) to receive said wirelessly received electric input signal; and c3) to provide a processed signal. The processor comprises a signal predictor for estimating future values of said wirelessly received electric input signal in dependence of a multitude of past values of said signal, thereby providing a predicted signal.

Abstract: A hearing device, e.g. a hearing aid, is configured to be arranged at least partly on a user's head or at least partly implanted in a user's head. The hearing device comprises a) at least one input transducer for picking up an input sound signal from the environment and providing at least one electric input signal representing said input sound signal; b) a signal processor connected to the at least one input transducer, the signal processor being configured to analyze the electric input signal and to provide a transmit control signal in dependence thereof; c) a memory buffer, e.g. a cyclic buffer, for storing a current time segment of a certain duration of said at least one electric input signal, or a processed version thereof; and a transmitter for transmitting at least a part of said time segment, or a processed version thereof, to an external device in dependence of said transmit control signal.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A semiconductor-on-insulator (e.g., silicon-on-insulator) structure having superior radio frequency device performance, and a method of preparing such a structure, is provided by utilizing a single crystal silicon handle wafer sliced from a float zone grown single crystal silicon ingot.

Abstract: An interconnect that has an electrically conductive layer, where a first and second insulator layers are coupled with the conductive layer. A region of the conductive layer includes an opening of a portion of the first insulator layer the second insulator layer that are adjacent to the region. An electrical connector of a first device is electrically coupled to a portion of the region on a first side of the conductive layer and an electrical conductor of a second device is electrically coupled with a portion of the region on the second side. Also, an interconnect coupled with a substrate that includes a cylinder extending from a side of the substrate with a plate coupled at the end of the cylinder with an opening that includes two or more tabs of the plate extending into the opening to receive a connector.

Abstract: A hearing device adapted for being located at or in an ear of a user, or for being fully or partially implanted in the head of a user comprises a) an input unit for providing at least one electric input signal representing sound in an environment of the user, said electric input signal comprising a target speech signal from a target sound source and additional signal components, termed noise signal components, from one or more other sound sources, b) a noise reduction system for providing an estimate of said target speech signal, wherein said noise signal components are at least partially attenuated, and c) an own voice detector for repeatedly estimating whether or not, or with what probability, said at least one electric input signal, or a signal derived therefrom, comprises speech originating from the voice of the user.

Abstract: An apparatus for delivering an implant to an eye using hydraulic fluid flow or pressure. An implant may be stored, advanced, and delivered to an eye using hydraulic fluid stored in a sterile container through a hollow advancement plunger. The plunger may rigidly advance the implant to a sealed position in a first phase, and then the implant may be advanced into the eye via hydraulic pressure or fluid flow in a second phase.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genetic alterations. In particular, a method is provided for that includes obtaining a set of sequence reads. The sequence reads each include a single molecule barcode (SMB) sequence that is a non-random oligonucleotide sequence. The method further includes assigning the sequence reads to read groups according to a read group signature. The read group signature comprises an SMB sequence and a start and end position of a nucleic acid fragment from the circulating cell free sample nucleic acid. The sequence reads comprising start and end positions and an SMB sequence similar to the read group signature are assigned to a read group. The method further includes generating a consensus for each read group, and determining the presence or absence of a genetic alteration based on the consensus for each read group.

Abstract: An emergency call data relay includes a frame buffer and a frame handler. The frame buffer stores data frames received from a central system (e.g., a central CPE host). The data frames include call data associated with an emergency call being handled at a remote system (e.g., a PSAP) connected to the central system. The frame handler receives a data frame from the frame buffer, identifies a remote system handling the emergency call associated with the call data based on a network address in the data frame, extracts the call data from the data frame, and generates an output packet for a data gateway. The output packet has a header indicating a particular data gateway profile associated with the identified remote system handling the emergency call.

Abstract: A binaural hearing system comprises first and second hearing aids, each comprising antenna and transceiver circuitry allowing the exchange of audio signals between them and a BTE-part adapted for being located at or behind the external ear (pinna) of the user and comprising front and rear input transducers providing respective front and rear electric input signals. Each of the hearing aids comprises primary and secondary adaptive 2-channel beamformers each providing a spatially filtered signal based on first and second beamformer-input signals. The primary and secondary 2-channel beamformers are coupled in a cascaded structure. The inputs to the primary 2-channel beamformers are, locally generated, front and rear electric input signals. The inputs to the secondary 2-channel beamformer may be beamformed signals from the first and second hearing aids respectively. The spatially filtered signal of the secondary 2-channel beamformer may comprise an estimate of a target signal in the environment of the user.

Abstract: An axle assembly includes a connection assembly having a stationary portion and a rotary portion. The stationary portion is configured to couple to an inlet airflow assembly configured to be non-movably coupled to a beam housing, the rotary portion is configured to couple to an outlet airflow assembly configured to be non-movably coupled to a steering knuckle, the stationary portion forms a cavity configured to facilitate flow of pressurized air from the inlet airflow assembly to the rotary portion, and the rotary portion forms an airflow path configured to facilitate flow of the pressurized air from the cavity to the outlet airflow assembly.

Abstract: Hematopoietic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell; and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.

Abstract: The coating can have a low-sweetness perception. During manufacturing and processing, the coating maintains a flowability to allow a glaze state of the coating to be applied to a food. Upon cooling, the glaze state of the coating forms a glass state that provides a low-sweetness impact which facilitates application of savory taste perceptions.

Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

Abstract: The present disclosure relates to devices, methods, and computer-readable medium for providing recommendations for alternate resources to use for cloud services. The devices, methods, and computer-readable medium may receive a resource allocation request for a new resource of a computing system and may predict an occurrence of a capacity related allocation for the resource allocation request. The devices, methods, and computer-readable medium may identify alternate resources to use for the resource allocation request and may provide recommendations with the alternate resources.

Abstract: Provided are methods of engulfing particles into droplets. The methods use a microfluidic device comprising a droplet generator and a chamber, the chamber comprising a liquid medium disposed on a voltage supply electrode and a ground electrode. The methods comprise dispensing a particle and a droplet into the liquid medium, and dielectrophoretically trapping the particle and the droplet using the voltage supply electrode and the ground electrode. The methods further comprise engulfing the particle into the droplet, wherein the engulfing comprises increasing a supply voltage between the voltage supply electrode and the ground electrode, thereby moving the droplet toward the voltage supply electrode and engulfing the particle into the droplet. In certain embodiments, the methods further comprise modifying the engulfed particle, assessing the engulfed particle, or both. Devices that find use in practicing the methods of the present disclosure are also provided.

Abstract: A method for operating a recirculating chemical-sanitizing dishwasher includes filling a wash tank of the dishwasher with water, and performing a first cycle of washing by circulating the water through a wash chamber of the dishwasher. A partial drain is performed of a first amount of water from the wash tank, and new water (for example, rinse water) is added to the wash tank for a second amount of water approximately equal to the first amount. A second cycle of washing is performed by circulating the water through the wash chamber of the dishwasher.

Abstract: A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.