Abstract: Apparatuses, systems, and methods relate to limiting torque applied to a rear axle. A vehicle includes a frame, a front tractive assembly coupled to the frame, a rear tractive assembly coupled to the frame, a prime mover coupled to the frame, a front tractive sensor, an output sensor, and a controller. The front tractive assembly includes a front axle. The rear tractive assembly includes a rear axle. The prime mover drives the front tractive assembly and the rear tractive assembly to propel the vehicle. The front tractive sensor collects data indicating a front power usage. The output sensor collects data indicating a power output of the prime mover. The controller is communicatively coupled to the front tractive sensor, the output sensor, and the prime mover. The controller de-rates the prime mover when the power output equals a sum of the power threshold and the front power usage.

Abstract: A continuous tire inflation system (CTIS) including a first outer O-ring, a second outer O-ring, a CTIS adopter in fluid communication to a trumpet housing, where the first outer O-ring and the second outer O-ring cause a seal between an outer surface of the CTIS adopter and the inner surface of the trumpet housing. The system including a first sealing bush adopter, a second sealing bush adopter, a first CTIS seal, a second CTIS seal, a first retaining ring configured to retain the first CTIS seal in physical contact with the CTIS adopter; a second retaining ring configured to retain the second CTIS seal in physical contact with the CTIS adopter.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: Implementations described herein relate to various semiconductor device assemblies. In some implementations, a semiconductor device assembly may include a first fan out redistribution layer, a first semiconductor die disposed on a first side, in a direction, of the first fan out redistribution layer and coupled to a first face of the first fan out redistribution layer, and a second semiconductor die disposed on a second side, in the direction, of the first fan out redistribution layer, different from the first side, and coupled to a second face of the first fan out redistribution layer, different from the first face.

Abstract: The coating can have a low-sweetness perception. During manufacturing and processing, the coating maintains a flowability to allow a glaze state of the coating to be applied to a food. Upon cooling, the glaze state of the coating forms a glass state that provides a low-sweetness impact which facilitates application of savory taste perceptions.

Abstract: A drug delivery device includes a dose counting mechanism and an end-of-content or remaining-dose indication. For example, a dose expelling mechanism is coupled to a reciprocating element configured to undergo a predefined motion during each dose expelling action to allow a dose to be expelled. The predefined motion includes displacement in a first axial direction from a first position to a second position followed by displacement in a second axial direction from the second position to the first position, with a counter element being movable in the first axial direction. First and second unidirectional ratchet mechanisms prevent motion in the first axial direction and allow motion in the second axial direction of the reciprocating element relative to the counter element, and vice versa, respectively.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: An adjustable steering stop includes a chassis stop configured to be coupled to a chassis member of a vehicle and a knuckle stop configured to be coupled to a steering knuckle. The chassis stop and the knuckle stop together define a steering limit location where the knuckle stop contacts the chassis stop. The adjustable steering stop further includes an adjustment actuator coupled to one of the chassis stop or the knuckle stop to move the chassis stop or the knuckle stop thereby changing the steering limit location.

Abstract: Methods, systems, and devices for arranging, completing, and paying for healthcare services using a portal. The systems and methods include: (1) requesting a healthcare procedure, (2) scheduling the healthcare procedure, (3) confirming pricing for the healthcare procedure, (4) authorizing payment for the healthcare procedure, (5) funding the healthcare procedure, (6) completing the healthcare procedure, (7) paying for the healthcare procedure, and/or (8) communicating with the healthcare provider, the payor, and/or the facility using the portal.

Abstract: An electronic system assembly includes a first circuit substrate having a surface, wherein the surface has a two-dimensional area defined in a first dimension and a second dimension; a plurality of first semiconductor chip packages mounted on and electrically coupled to the surface; a plurality of second circuit substrates positioned over the surface, wherein each first semiconductor chip package is arranged between the surface and a respective second circuit substrate in a third dimension; a plurality of conductive interconnect structures that extend in the third dimension, wherein the plurality of conductive interconnect structures are provided in a plurality of interconnect groups, and wherein each interconnect group connects a different second circuit substrate to the first circuit substrate; and a plurality of second semiconductor chip packages, wherein each second semiconductor chip package is mounted and electrically coupled to a respective second circuit substrate.

Abstract: An axle assembly includes a connection assembly having a stationary portion and a rotary portion. The stationary portion is configured to couple to an inlet airflow assembly configured to be non-movably coupled to a beam housing, the rotary portion is configured to couple to an outlet airflow assembly configured to be non-movably coupled to a steering knuckle, the stationary portion forms a cavity configured to facilitate flow of pressurized air from the inlet airflow assembly to the rotary portion, and the rotary portion forms an airflow path configured to facilitate flow of the pressurized air from the cavity to the outlet airflow assembly.

Abstract: Hematopoietic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell; and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.

Abstract: The coating can have a low-sweetness perception. During manufacturing and processing, the coating maintains a flowability to allow a glaze state of the coating to be applied to a food. Upon cooling, the glaze state of the coating forms a glass state that provides a low-sweetness impact which facilitates application of savory taste perceptions.

Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

Abstract: The present disclosure relates to devices, methods, and computer-readable medium for providing recommendations for alternate resources to use for cloud services. The devices, methods, and computer-readable medium may receive a resource allocation request for a new resource of a computing system and may predict an occurrence of a capacity related allocation for the resource allocation request. The devices, methods, and computer-readable medium may identify alternate resources to use for the resource allocation request and may provide recommendations with the alternate resources.

Abstract: Provided are methods of engulfing particles into droplets. The methods use a microfluidic device comprising a droplet generator and a chamber, the chamber comprising a liquid medium disposed on a voltage supply electrode and a ground electrode. The methods comprise dispensing a particle and a droplet into the liquid medium, and dielectrophoretically trapping the particle and the droplet using the voltage supply electrode and the ground electrode. The methods further comprise engulfing the particle into the droplet, wherein the engulfing comprises increasing a supply voltage between the voltage supply electrode and the ground electrode, thereby moving the droplet toward the voltage supply electrode and engulfing the particle into the droplet. In certain embodiments, the methods further comprise modifying the engulfed particle, assessing the engulfed particle, or both. Devices that find use in practicing the methods of the present disclosure are also provided.

Abstract: A method for operating a recirculating chemical-sanitizing dishwasher includes filling a wash tank of the dishwasher with water, and performing a first cycle of washing by circulating the water through a wash chamber of the dishwasher. A partial drain is performed of a first amount of water from the wash tank, and new water (for example, rinse water) is added to the wash tank for a second amount of water approximately equal to the first amount. A second cycle of washing is performed by circulating the water through the wash chamber of the dishwasher.

Abstract: A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.