Patents by Inventor Michael Jerome Bienkowski
Michael Jerome Bienkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7888291Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: GrantFiled: March 16, 2004Date of Patent: February 15, 2011Assignee: Elan Pharmaceuticals, Inc.Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Patent number: 7812123Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.Type: GrantFiled: September 14, 2004Date of Patent: October 12, 2010Assignee: Elan Pharmaceuticals, Inc.Inventors: Mark E. Gurney, Michael Jerome Bienkowski, Robert Leroy Heinrikson, Luis A. Parodi, Riqiang Yan
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Patent number: 7803739Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: GrantFiled: March 16, 2004Date of Patent: September 28, 2010Assignee: Elan Pharmaceuticals, Inc.Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Publication number: 20090162883Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the ?-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.Type: ApplicationFiled: November 19, 2008Publication date: June 25, 2009Applicant: Pharmacia & Upjohn CompanyInventors: Mark Gurney, Michael Jerome Bienkowski
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Publication number: 20080299596Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: ApplicationFiled: March 1, 2007Publication date: December 4, 2008Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Patent number: 7456269Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the ?-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.Type: GrantFiled: April 5, 2004Date of Patent: November 25, 2008Assignee: Pharmacia & Upjohn CompanyInventors: Mark E. Gurney, Michael Jerome Bienkowski
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Patent number: 7205120Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: GrantFiled: July 19, 2001Date of Patent: April 17, 2007Assignee: Pharmacia & Upjohn CompanyInventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Patent number: 6844148Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the ?-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.Type: GrantFiled: September 22, 2000Date of Patent: January 18, 2005Assignee: Pharmacia & Upjohn CompanyInventors: Mark Gurney, Michael Jerome Bienkowski
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Patent number: 6835565Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.Type: GrantFiled: September 17, 2001Date of Patent: December 28, 2004Assignee: Pharmacia & Upjohn CompanyInventors: Mark E. Gurney, Michael Jerome Bienkowski, Robert Leroy Heinrikson, Luis A. Parodi, Riqiang Yan
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Publication number: 20040254341Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: ApplicationFiled: March 16, 2004Publication date: December 16, 2004Applicant: Pharmacia & Upjohn Company, a Delaware corporationInventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Publication number: 20040254342Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: ApplicationFiled: March 16, 2004Publication date: December 16, 2004Applicant: Pharmacia & Upjohn Company, a Delaware corporationInventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Publication number: 20040253706Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: ApplicationFiled: March 16, 2004Publication date: December 16, 2004Applicant: Pharmacia & Upjohn Company, a Delaware corporationInventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Publication number: 20040241792Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: ApplicationFiled: March 16, 2004Publication date: December 2, 2004Applicant: Pharmacia & Upjohn Company, a Delaware corporationInventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Publication number: 20040171535Abstract: The present invention provides a cDNA encoding a heretofore unknown enzyme termed heparanase II; constructs and recombinant host cells incorporating the cDNA; the heparanase II polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making an using all of the foregoing.Type: ApplicationFiled: October 24, 2002Publication date: September 2, 2004Inventors: Robert Leroy Heinrikson, Michael Jerome Bienkowski
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Publication number: 20030017991Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.Type: ApplicationFiled: July 19, 2001Publication date: January 23, 2003Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
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Publication number: 20020064853Abstract: The present invention provides a cDNA encoding a heretofore unknown enzyme termed heparanase II; constructs and recombinant host cells incorporating the cDNA; the heparanase II polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing.Type: ApplicationFiled: April 17, 2001Publication date: May 30, 2002Inventors: Robert Leroy Heinrikson, Michael Jerome Bienkowski
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Patent number: 5882873Abstract: The present invention comprises human DNA compositions encoding proteins that confer potassium channel activity to membranes or recipient cell lines. The DNA compositions include structural genes coding for the potassium channel proteins, expression and replication plasmids or vectors containing the structural genes and host cells expressing those genes. Methods of screening compounds for potassium channel modulating activity are also described.Type: GrantFiled: August 9, 1995Date of Patent: March 16, 1999Assignee: Pharmacia & Upjohn CompanyInventors: Michael Jerome Bienkowski, Vincent Edward Groppi, Jr.
