Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Provided herein are Sirt1 polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution and the nucleic acid variants have a T373C substitution. Genetic and/or biochemical testing may be performed to identify whether a patient carries one of the disclosed polymorphic variants. Based on the polymorphic variant the patient carries, a medical practitioner may administer an appropriate therapy, such as a sirtuin activator.

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. In the case of a device (1) for scanning a disc-shaped data carrier (2), with a pivotable data carrier plate (4), which features a receptacle for the data carrier (2), said data carrier (2) is to be able to be moved between the inlay position and the scanning position, which is at a higher level than the inlay position, by means of a combined sliding and swivel action, in order to minimize the design height of the device (1) with an adjustably held transport system (5) for moving the data carrier (2) between an inlay position and a scanning position, in which scanning position the data carrier (2) is located on the data carrier plate (4) for scanning, and with a guide device, such as a lever (9) or sliding blocks (17, 18).

Abstract: Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. In the case of a device (1) for scanning a disc-shaped data carrier (2), with a pivotable data carrier plate (4), which features a receptacle for the data carrier (2), said data carrier (2) is to be able to be moved between the inlay position and the scanning position, which is at a higher level than the inlay position, by means of a combined sliding and swivel action, in order to minimize the design height of the device (1) with an adjustably held transport system (5) for moving the data carrier (2) between an inlay position and a scanning position, in which scanning position the data carrier (2) is located on the data carrier plate (4) for scanning, and with a guide device, such as a lever (9) or sliding blocks (17, 18).