Patents by Inventor Michael Jobling

Michael Jobling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant forms of cholera holotoxin as an adjuvant
    Publication number: 20070122428
    Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
    Type: Application
    Filed: December 22, 2006
    Publication date: May 31, 2007
    Applicants: Wyeth Holdings Corporation, University of Health Sciences
    Inventors: Bruce Green, Randall Holmes, Michael Jobling, Duzhang Zhu
  • Mutant forms of cholera holotoxin as an adjuvant
    Publication number: 20070116715
    Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
    Type: Application
    Filed: December 15, 2006
    Publication date: May 24, 2007
    Applicants: Wyeth, University of Colorado
    Inventors: Bruce Green, Randall Holmes, Michael Jobling, Duzhang Zhu