Abstract: The invention relates to compounds, compositions, and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.

Abstract: A mobile smart container system comprises a housing, an access component configured to secure access to a compartment within the housing when in a closed position, a communication interface configured to wirelessly receive a request to access the compartment, a perceivable output device, an electromechanical latch configured to engage with the access component to releasably lock the access component in the closed position, and a processor. The processor receives and authenticates the request to access the compartment and, in response to receiving and authenticating the request, activates the electromechanical latch to unlock the access component to make the compartment accessible, and outputs, upon actuation of the electromechanical latch, an alert via the perceivable output device to identify the smart container system.

Abstract: Locking actuators for thrust reverser actuation systems, engines and aircraft including the same, and associated methods. A locking actuator includes an actuator housing, an extension element, and a lock assembly. The extension element is configured to translate along an actuator axis to transition between a retracted state and an extended state. The lock assembly transitions between a locked state and an unlocked state independent of transitioning the extension element between the retracted and extended states. In examples, a thrust reverser actuation system includes an actuator assembly with the locking actuator and a hydraulic control assembly. In examples, an engine includes a thrust generator, a nacelle, a transcowl, and the thrust reverser actuation system. In examples, a method of operating a thrust reverser actuation system includes transitioning a lock assembly from a locked state to an unlocked state and transitioning an extension element from a retracted state to an extended state.

Abstract: Locking actuators for thrust reverser actuation systems, engines and aircraft including the same, and associated methods. A locking actuator includes an actuator housing, an extension element, and a lock assembly. The extension element is configured to translate along an actuator axis to transition between a retracted state and an extended state. The lock assembly transitions between a locked state and an unlocked state independent of transitioning the extension element between the retracted and extended states. In examples, a thrust reverser actuation system includes an actuator assembly with the locking actuator and a hydraulic control assembly. In examples, an engine includes a thrust generator, a nacelle, a transcowl, and the thrust reverser actuation system. In examples, a method of operating a thrust reverser actuation system includes transitioning a lock assembly from a locked state to an unlocked state and transitioning an extension element from a retracted state to an extended state.

Abstract: There is provided an actuation system for a gas turbine engine including a thrust reverser and a variable area fan nozzle. The system has a plurality of linear actuators each having a first outer piston concentric with a second inner piston. The first outer piston is operatively connected to a thrust reverser. The second inner piston is operatively connected to a variable area fan nozzle. The system further has a piston lock assembly for selectively locking the first outer piston to the second inner piston. The system further has a control system coupled to the plurality of linear actuators for operating the variable area fan nozzle between a stowed position and a deployed position.

Abstract: There is provided an actuation system for a gas turbine engine including a thrust reverser and a variable area fan nozzle. The system has a plurality of linear actuators each having a first outer piston concentric with a second inner piston. The first outer piston is operatively connected to a thrust reverser. The second inner piston is operatively connected to a variable area fan nozzle. The system further has a piston lock assembly for selectively locking the first outer piston to the second inner piston. The system further has a control system coupled to the plurality of linear actuators for operating the variable area fan nozzle between a stowed position and a deployed position.