Abstract: Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy without hypertension are disclosed. Preferred methods comprise the administration of a therapeutically effective amount of the dual SGLT1/2 inhibitor sotagliflozin.

Abstract: Methods of using a sodium glucose cotransporter 2 (SGLT2) inhibitor to treat type 1 diabetes, improve cardiovascular health, slow kidney function decline, reduce the risk of cardiovascular death, and reduce the risk of hospitalization for heart failure while minimized adverse events such as diabetic ketoacidosis and severe hypoglycemia are disclosed. In preferred methods, the SGLT2 inhibitor is sotagliflozin. Methods of prescribing and administering sotagliflozin are also disclosed.

Abstract: A technique for efficient calling of functions on a processor generates an executable program having a function call by analysing an interface for the function that defines an argument expression and an internal value used solely within the function, and an argument declaration defining an argument value to be provided to the function when the program is run. A data structure is generated including the internal value and a resolved argument value derived from the argument expression and the argument value. A single instruction is encoded in the program to utilise the data structure. When the program is executed on a processor, the single instruction causes the processor to load the argument value and internal value from the data structure into registers in the processor, prior to evaluating the function. The function can then be executed without further register loads being performed.

Abstract: The disclosure relates to the field of lymphedema therapy, more specifically, to a new pharmacological strategy to rescue the failed lymph pump system that can supplement, enhance or replace current therapies.

Abstract: A technique for efficient calling of functions on a processor generates an executable program having a function call by analysing an interface for the function that defines an argument expression and an internal value used solely within the function, and an argument declaration defining an argument value to be provided to the function when the program is run. A data structure is generated including the internal value and a resolved argument value derived from the argument expression and the argument value. A single instruction is encoded in the program to utilise the data structure. When the program is executed on a processor, the single instruction causes the processor to load the argument value and internal value from the data structure into registers in the processor, prior to evaluating the function. The function can then be executed without further register loads being performed.

Abstract: A pressure-applying device is generally used in workout (exercise) environments for applying pressure to release tension developed in muscles during heavy physical activity, such as power lifting. The device can be used for both roller applications, typically along the human back and point applications, which may be on the back or other points that accrue muscle tension during exercise. The device includes a cylindrical roller portion and end extensions extending from the roller portion at each end and aligned with the central axis of the roller portion. The extensions are sized to accept standard barbell weights. The result is a relatively light shipping weight and low cost roller device that can apply pressure far in excess of its own weight, reducing shipping/fabrication costs and increasing portability while the barbell weights are not mounted on the device.

Abstract: Methods and apparatus for efficient loading of data from memory to registers and storing of data from registers to memory are described. In an embodiment, a processor comprises a data structure to which addresses which are used for load operations are pushed. Instead of independently generating addresses for a store operation, addresses are popped from the data structure and either used directly or an optional offset may first be applied to the popped address. In this way, a store operation and a load operation may be performed in parallel because they do not both require use of the logic which independently generates addresses for load/store operations. In various examples, the data structure is a FIFO structure.

Abstract: The disclosure relates to the field of lymphedema therapy, more specifically, to a new pharmacological strategy to rescue the failed lymph pump system that can supplement, enhance or replace current therapies.

Abstract: Methods and apparatus for efficient loading of data from memory to registers and storing of data from registers to memory are described. In an embodiment, a processor comprises a data structure to which addresses which are used for load operations are pushed. Instead of independently generating addresses for a store operation, addresses are popped from the data structure and either used directly or an optional offset may first be applied to the popped address. In this way, a store operation and a load operation may be performed in parallel because they do not both require use of the logic which independently generates addresses for load/store operations. In various examples, the data structure is a FIFO structure.

Abstract: The present invention generally relates to asphalt mixes with a high content of recycled bituminous materials including a binder modified with glycerol. The present invention further relates to a method for preparing the asphalt mixes and to the use of the asphalt mixes as materials for making courses and/or surfacing for road construction and/or civil engineering. The present invention also relates to the use of glycerol as a correcting agent for the workability and/or of the thermal cracking resistance and/or of the rutting resistance of an asphalt mix with a high content of recycled bituminous materials.

Abstract: A method of forming a poly(arylene ether)-containing solid concentrate is described. The method includes blending a poly(arylene ether), a thermosetting resin, and a compatibilizing agent in the presence of a solvent to form a homogeneous solution, and removing the solvent to yield the solid concentrate. The solid concentrate is useful for preparing curable conditions.

Abstract: A system for the inspection of and a process for the correction of defects in a microreplicated optical display film manufacturing process. The process steps of manufacturing a master, a plurality of shims from the master, and a multiplicity of display films from each shim are integrated with a systemic defect identification and correction process. Each primary manufacturing step has its own inspection system and correction process where defect information for that step of the process is fed back and analyzed; and from that analysis the subprocess is adjusted to eliminate or reduce the detected defect. The systemic defect is identified as to its source and then fed back and analyzed in the correction step of the respective subprocess in order to cure the root of the defect.

Abstract: A moldable thermosetting composition comprises a poly(arylene ether), a thermosetting resin, a toughening agent, and an amine cure agent. The compositions may be conveniently prepared without solvents, and the poly(arylene ether) may be provided in the form of an easily dissolved solid concentrate with the thermosetting resin.

Abstract: A processor system is formed from a plurality of processor elements (6). A plurality of registers (8) are provided for use with the processing elements and an instruction decoder (4) is configured to decode a first portion of at least one Very Long Instruction Word (VLIW) as a multiple register load instruction. A second larger portion of the VLIW is decoded as data to enable loading of a plurality of individual ones of a plurality of registers.

Abstract: This invention is directed to an adhesive resin composition having better processability, exhibiting reduced B-staged (partially cured) friability, and capable of being produced in a wide range of flow characteristics dependent upon the applications desired. Specifically, the composition, comprising a poly(arylene ether)-polyvinyl resin and curable unsaturated monomer, is applied to a metal foil or thermoplastic substrate or a free-standing film. The thermoplastic substrate may have an electrically conductive metal, such as copper, on one side. Better final film properties can be achieved by tailored functionality of cross-linking by control of ingredients and/or chain length (molecular weight) of ingredients used in making the novel adhesive composition.

Abstract: A processor system includes a programmable very long instruction word (VLIW) processor which is closely coupled to a data memory. There is also provided a memory for storing instruction words for the VLIW processors. A memory access unit is coupled to a data memory and at least one input side is dedicated processor is coupled between a data input and the memory access unit. Furthermore, at least one output side dedicated processor is coupled between the memory access unit and the data output. The input and output side data processors perform operations common to a plurality of data processors on input and output data and the VLIW processor performs operations on data particular to a process being performed by the processor system. The VLIW processor is loaded with different sets of instruction words in dependence on the process being performed by the processor system.

Abstract: A pharmaceutical for use in damaged tissue, such as wound, treatment (e.g. healing) is described. The pharmaceutical comprising a composition which comprises: (a) a growth factor; and (b) an inhibitor agent; and optionally (c) a pharmaceutically acceptable carrier, diluent or excipient; wherein the inhibitor agent can inhibit the action of at least one specific adverse protein (e.g. a specific protease) that is upregulated in a damaged tissue, such as a wound, environment.

Abstract: This invention relates to the use of cyclic guanosine 3′, 5′-monophosphate phosphodiesterase type five (cGMP PDE5) inhibitors, including in particular the compound sildenafil, for the treatment of diabetic ulcers, particularly diabetic foot ulcers.

Abstract: A moldable thermosetting composition comprises a poly(arylene ether), a thermosetting resin, a toughening agent, and an amine cure agent. The compositions may be conveniently prepared without solvents, and the poly(arylene ether) may be provided in the form of an easily dissolved solid concentrate with the thermosetting resin.