Abstract: A device for injecting a medicament is provided. The device has a housing with a container within it which can hold a medicament. At its proximal end the container has a needle and a stopper. The device includes a plunger which at one end can engage the stopper. At the opposite end, the plunger can engage a first resilient member to move the stopper within the container to inject the medicament from the container. The device includes a collar with distal and proximal ends, the distal end engaging with a carriage and causing its rotation and the proximal end engaging with a second resilient member. The second resilient member can engage with a skin sensor which has distal and proximal ends. At the proximal end, the skin sensor can contact an injection site. The housing has a cap which can reduce or prevent movement of the skin sensor.

Abstract: A device for injecting a medicament is provided. The device has a housing with a container within it which can hold a medicament. At its proximal end the container has a needle and a stopper. The device includes a plunger which at one end can engage the stopper. At the opposite end, the plunger can engage a first resilient member to move the stopper within the container to inject the medicament from the container. The device includes a collar with distal and proximal ends, the distal end engaging with a carriage and causing its rotation and the proximal end engaging with a second resilient member. The second resilient member can engage with a skin sensor which has distal and proximal ends. At the proximal end, the skin sensor can contact an injection site. The housing has a cap which can reduce or prevent movement of the skin sensor.

Abstract: A device for injecting a medicament is provided. The device has a housing with a container within it which can hold a medicament. At its proximal end the container has a needle and a stopper. The device includes a plunger which at one end can engage the stopper. At the opposite end, the plunger can engage a first resilient member to move the stopper within the container to inject the medicament from the container. The device includes a collar with distal and proximal ends, the distal end engaging with a carriage and causing its rotation and the proximal end engaging with a second resilient member. The second resilient member can engage with a skin sensor which has distal and proximal ends. At the proximal end, the skin sensor can contact an injection site. The housing has a cap which can reduce or prevent movement of the skin sensor.

Abstract: The present invention relates to a low-cost single-use disposable breath actuated dry powder inhaler, its method of use, and method of manufacture. The inhaler comprises a bottom layer and a top layer. The inhaler comprises a medicament compartment and an air passageway. Furthermore, the medicament compartment is sealed by a flexible pull tab that is easily removed before use, and the air passageway comprises a mouthpiece port, a Venturi section, and an air inlet port.

Abstract: An apparatus for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms includes a mixer for mixing a sump of the powder material to electrostatically charge the powder material, the mixer including two substantially parallel elongate mixing shafts having oppositely angled mixing paddles thereon and being arranged to rotate in opposite directions; and a feeder for removing the electrostatically charged powder material from the sump and supplying it to the applicator, and a method for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms.

Abstract: An apparatus for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms includes a mixer for mixing a sump of the powder material to electrostatically charge the powder material, the mixer including two substantially parallel elongate mixing shafts having oppositely angled mixing paddles thereon and being arranged to rotate in opposite directions; and a feeder for removing the electrostatically charged powder material from the sump and supplying it to the applicator, and a method for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms.

Abstract: Apparatuses (201) and methods for electrostatically applying a powder material to substrates are described. A plurality of platens (202, 203) are provided, each arranged to hold a plurality of substrates such as solid dosage forms (101, 111). Each platen (202, 203) is driven around an endless path and passes through a loading region (FIGS. 3, 4) in which substrates are loaded onto the platens (202, 203), a developing region (FIGS. 5, 6) in which the powder material is applied to the substrates, a fusing region (FIG. 7) in which the applied powder material is fused, and an unloading region (FIG. 8) in which substrates are removed from the platens (202, 203).

Abstract: A metered dose inhaler for use with a pressurized aerosol container which is preferably breath-actuated. A preload (80) is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force (130). The inhaler comprises a release device (110) which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve (135). A metered dose of medicament is then released for inhalation by the patient. The pneumatic resisting force is established by a negative pressure region defined in part by a diaphragm. The diaphragm includes a central disk of a first, relatively high stiffness material and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material.

Abstract: A dose counter for a metered dose inhaler comprises actuator means (341), drive means (350) for driving a rotary gear (360) in step-wise fashion in response to displacement of said actuator means (341), said rotary gear (360) comprising a wheel having a plurality of ratchet teeth (not shown) around its periphery. Means (364) are provided to prevent reverse rotation of the rotary gear (360). A flexible tape (368) is provided with a visible array of incrementing integers on its surface indicating the number of medicament doses remaining in the inhaler. The tape (368) indexes by a single integer in response to each step of the step-wise rotary motion of the rotary gear (360). A control surface (371) regulates the position of engagement and disengagement between the drive means (350) and the rotary gear (360). In an alternative embodiment (FIG. 6), the control surface (371) is omitted and the means for preventing reverse rotation comprise a stepless restraint (664).