Abstract: An electrolytic biosensor for use in intracorporeal leak detection may be incorporated into a surgical drain that is installed post-operatively at the site of a wound. The electrolytic biosensor may be used to monitor drain effluent flowing through the surgical drain by measuring a fluid conductivity of the drain effluent. Certain changes, patterns, or responses of the so measured fluid conductivity values may be indicative of a physiological condition of the wound. For example, when the wound is a gastrointestinal anastomosis, the fluid conductivity values measured with the electrolytic biosensor may be used to characterize a fluid integrity of the gastrointestinal anastomosis. An electrolytic biosensor system may include an application that records conductivity data and provides notifications, such as a patient alarm, when a leak is detected.