Abstract: A printhead for an inkjet printer that has a printhead integrated circuit (68) with nozzles for ejecting ink, and a support structure (64, 176, 108) for supporting the printhead IC. The support structure has ink conduits (182) for supplying the nozzles with ink and a fluidic damper 200 containing gas for compression by pressure pulses in the ink within the ink conduits to dissipate the pressure pulse. Damping pressure pulses using gas compression can be achieved with small volumes of gas. This preserves a compact design while avoiding any nozzle flooding from transient spikes in the ink pressure.

Abstract: A printhead for an inkjet printer that has a printhead integrated circuit (68) with nozzles for ejecting ink and a support structure (64, 174, 176) for supporting the printhead IC. The support structure having ink conduits (182) for supplying the array of nozzles. A plurality of cavities (200), each cavity having an opening that establishes fluid communication with the ink conduits, the openings being configured such that the cavities do not prime with ink when the ink conduits are primed from the ink supply. By leaving unprimed cavities throughout the support structure, any pressure pulses in the ink are damped by compression of the trapped gas pockets. Distributing the cavities rather than using one relatively large cavity, means that the pressure pulse is being damped along the length of the printhead IC, instead of allowing the pulse to travel the length of the ink conduit until it reaches the single damper and compresses the gas.

Abstract: A printhead for an inkjet printer that has an elongate array of nozzles (68) for ejecting ink and ink conduits for supplying the array of nozzles with ink. The ink conduits extend adjacent the elongate array and have a plurality of pulse dampers individually in fluid communication with the ink conduits, each containing a volume of gas for compression by pressure pulses in the ink conduits, distributed along the length of the elongate array. A pressure pulse moving through an elongate printheads, such as a pagewidth printhead, can be damped at any point in the ink flow line. However, the pulse will cause nozzle flooding as it passes the nozzles in the printhead integrated circuit, regardless of whether it is subsequently dissipated at the damper. By incorporating a number of pulse dampers into the ink supply conduits immediately next to the nozzle array, any pressure spikes are damped at the site where they would otherwise cause detrimental flooding.

Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.

Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise conimensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.

Abstract: The invention provides methods of screening commensal and pathogenic bacteria for previously unidentified vaccine antigens, based upon identifying polypeptide antigens that bind to sera raised against commensal bacterial proteins. Also provided are vaccine compositions and methods of preparing vaccine compositions comprising the antigens identified by the screening methods. Antigens and uses thereof are also described.

Abstract: A composition comprising Transferrin binding proteins A and B is described (TbpA and TbpB). The composition is suitable for use in vaccines and for treatment of Gram negative bacterial infection, particularly meningococcal infection, demonstrating a broad spectrum of protection to a number of different bacterial pathogens. Also described are compositions comprising Tbps and other components, such as neisserial outer membrane vesicles and Cu,Zn-Superoxide dismutase. Methods for preparation of these compositions and their uses in vaccination against disease are further provided.

Abstract: A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.

Abstract: Neisserial iron uptake proteins including transferrin binding protein A (TbpA) and B (TbpB) in both full length form and as immunogenic fragments are made recombinantly. A non-neisserial cell expresses a TbpA which is extracted from the cell under mild conditions and retains substantially the antigenicity of native TbpA on its surface. TbpB is also made recombinantly and both TbpA and TbpB are included in vaccine compositions.

Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.

Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.