Abstract: A detection mechanism is disclosed for identifying peers transmitting network traffic towards a cloud provider using routing prefixes that were not advertised for that peer. Once detected, an alarm condition can occur and the peer notified to remove any static route configurations. In one embodiment, a collector server computer can be used to acquire routing prefixes advertised to a peer. A second server computer can be used to obtain network traffic received from the peer. A comparison can then be made between the advertised prefixes and the network traffic being received. If network traffic is being received for unadvertised prefixes, then an alarm condition can occur. The detection mechanism can regularly inspect active traffic flows against BGP route advertisements at fixed intervals. For peers that are identified that are not in compliance with route advertisements, the alarm condition can occur for follow-up remediation.

Abstract: Triosephosphate isomerase deficiency (TPI Df) is a devastating childhood degenerative disease for which there are currently no treatments. Pathogenesis of this disease is driven by mutations that destabilize the TPI protein. A genome-wide RNAi screen in Drosophila to identify regulators of TPI stability is described. The screen identified 25 proteins that are critical to TPI stability, each of which has a human ortholog. Methods of promoting TPI protein stability and treating TPI Df in a subject by administering a therapeutically effective amount of an agent that inhibits expression or activity of one of the identified regulators are described. Also described is a method for the identification of agents capable of promoting stability of mutant TPI. Methods for treating a subject who has TPI Df by administering an agent that promotes stability of mutant TPI is also described.