Abstract: According to the present invention there is provided a peptide combination, capable of inducing dermal extracellular matrix protein upregulation, comprising; a) a first peptide selected from the group consisting of tetrapeptides having the amino acid sequence U-LSXX-Z; and b) a second peptide selected from the group consisting of tetrapeptides having the amino acid sequence U-GPXG-Z.

Abstract: According to the present invention, there is provided a tetrapeptide, capable of inducing dermal extracellular matrix protein upregulation, having the amino acid sequence U-(SEQ ID No: 1)-Z, U-(SEQ ID No: 2)-Z, U-(SEQ ID No: 3)-Z, U-(SEQ ID No: 4)-Z, U-(SEQ ID No: 5)-Z, U-(SEQ ID No: 6)-Z, U-(SEQ ID No: 7)-Z, U-(SEQ ID No: 8)-Z, U-(SEQ ID No: 9)-Z, U-(SEQ ID No: 11)-Z, U-(SEQ ID No: 12)-Z, U-(SEQ ID No: 13)-Z, U-(SEQ ID No: 14)-Z, U-(SEQ ID No: 15)-Z, U-(SEQ ID No: 16)-Z, U-(SEQ ID No: 17)-Z, U-(SEQ ID No: 18)-Z, U-(SEQ ID No: 19)-Z, U-(SEQ ID No: 20)-Z, U-(SEQ ID No: 21)-Z, U-(SEQ ID No: 22)-Z, U-(SEQ ID No: 23)-Z, U-(SEQ ID No: 24)-Z, U-(SEQ ID No: 25)-Z, U-(SEQ ID No: 26)-Z, U-(SEQ ID No: 27)-Z, U-(SEQ ID No: 28)-Z, and U-(SEQ ID No: 29)-Z.

Abstract: According to the present invention, there is provided a tetrapeptide, capable of inducing dermal extracellular matrix protein upregulation, selected from the group consisting of tetrapeptides having the amino acid sequence U-LSXX-Z wherein L is used to denote amino acid Leucine and S is used to denote Serine, as per the internationally recognised single letter code for amino acids, X denotes an amino acid selected from the group consisting of Valine (V), Aspartic acid (D), Proline (P), Glycine (G) and mixtures thereof, at the N-terminal end, U is selected from the group consisting of H, —CO—R1, —SO2—R1 or a biotinyl group, at the C-terminal end, Z is selected from the group consisting of OH, O R1, NHR1 or NR1R2; wherein if U is H then Z cannot be OH and R1 and R2 are independently selected from the group consisting of alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclical, polycyclic, unsaturated, hydroxylates, carbonylated, phosphorylated and/or sulphur

Abstract: A tetrapeptide, capable of inducing dermal extracellular matrix protein upregulation, selected from the group consisting of tetrapeptides having the amino acid sequence U-QTAV-Z wherein Q denotes Glutamine, T denotes Threonine, A denotes Alanine and V denotes Valine, at the N-terminal end, U is independently selected from the group consisting of octanoyl (C8), decanoyl (C10), lauroyl (C12), myristoyl (C14), palmitoyl (C16), stearoyl (C18), biotinoyl, elaidoyl, oleoyle, lipoyle, at the C-terminal end, Z is selected from the group consisting of OH, O R1, NHR1 or NR1R2, R1 and R2 are independently selected from the group consisting of alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclical, polycyclic, unsaturated, hydroxylates, carbonylated, phosphorylated and/or sulphurous, said groups comprising from 1 to 24 carbon atoms and being capable of including one or more heteroatoms O, S and/or N.