Patents by Inventor Michael John Zaworotko
Michael John Zaworotko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230203065Abstract: A cocrystal having the formula LiX·aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: ApplicationFiled: October 4, 2022Publication date: June 29, 2023Inventors: Michael John ZAWOROTKO, Naga DUGGIRALA, Adam John SMITH, Roland Douglas SHYTLE
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Publication number: 20220355268Abstract: A method of purifying gaseous mixtures, for example ternary or quaternary gaseous mixtures, using a sorbent media comprising two or more sorbent materials. The method involves obtaining a target gas from a gaseous composition comprising the target gas, a first gas and a second gas, and optionally further gases by contacting the gaseous composition with the sorbent media to remove at least some of the first gas and at least some of the second gas from the gaseous composition. The sorbent media comprises at least a first sorbent material and a second sorbent material; wherein the first sorbent material has a higher adsorption selectivity for the first gas than for the target gas; and wherein the second sorbent material has a higher adsorption selectivity for the second gas than for target gas. The method may be particularly useful for the separation of pure ethylene, methane or propylene from such gaseous mixtures.Type: ApplicationFiled: September 13, 2020Publication date: November 10, 2022Inventors: Michael John ZAWOROTKO, Kai-Jie CHEN, David G MADDEN, Soumya MUKHERJEE, Amrit KUMAR
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Patent number: 11459341Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: GrantFiled: December 11, 2020Date of Patent: October 4, 2022Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
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Publication number: 20210162338Abstract: A method of capturing water from a gaseous composition comprising water vapour (suitably air), the method comprising: (a) providing a metal-organic material; and (b) contacting themetal-organic material with water and/or water vapour; wherein upon contact with water and/or water vapour the material switches from a first state to a second state wherein the second state is able to retain a higher amount of water than the first state.Type: ApplicationFiled: July 26, 2019Publication date: June 3, 2021Inventors: Michael John ZAWOROTKO, Victoria Gascón PÉREZ, Andrey Alexandrovich BEZRUKOV, Daniel John O'HEARN, Shiqiang WANG
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Patent number: 10870665Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: GrantFiled: August 28, 2019Date of Patent: December 22, 2020Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
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Patent number: 10842797Abstract: Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.Type: GrantFiled: May 24, 2019Date of Patent: November 24, 2020Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Michael John Zaworotko, Heather Clarke, Arora Kapildev, Padmini Kavuru, Roland Douglas Shytle, Twarita Pujari, Lissette Marshall, Tien Teng Ong
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Publication number: 20200030737Abstract: A method of capturing water from a gaseous composition comprising water vapour (e.g., air), the method comprising: (a) providing a metal-organic material; and (b) contacting the metal-organic material with water and/or water vapour; wherein upon contact with water and/or water vapour the material switches from a first state to a second state wherein the second state is able to retain a higher amount of water than the first state.Type: ApplicationFiled: July 26, 2019Publication date: January 30, 2020Inventors: Michael John Zaworotko, Victoria Gascón Pérez, Andrey Alexandrovich Bezrukov, Daniel J. O'Hearn, Shiqiang Wang
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Patent number: 10435416Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: GrantFiled: October 25, 2017Date of Patent: October 8, 2019Assignee: University of South FloridaInventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
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Publication number: 20190275056Abstract: Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.Type: ApplicationFiled: May 24, 2019Publication date: September 12, 2019Inventors: Michael John ZAWOROTKO, Heather CLARKE, Arora KAPILDEV, Padmini KAVURU, Roland Douglas SHYTLE, Twarita PUJARI, Lissette MARSHALL, Tien Teng ONG
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Patent number: 10376521Abstract: Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.Type: GrantFiled: November 5, 2014Date of Patent: August 13, 2019Assignee: University of South FloridaInventors: Michael John Zaworotko, Heather Clarke, Arora Kapildev, Padmini Kavuru, Roland Douglas Shytle, Twarita Pujari, Lissette Marshall, Tien Teng Ong
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Patent number: 10130708Abstract: 2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms.Type: GrantFiled: March 26, 2012Date of Patent: November 20, 2018Assignee: University of South FloridaInventors: Michael John Zaworotko, Roland D. Shytle, Tien Teng Ong, Ryan N. Cantwell, Tranhha Nguyen, Adam John Smith, Padmini Kavuru
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Publication number: 20180057511Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: ApplicationFiled: October 25, 2017Publication date: March 1, 2018Applicant: University of South FloridaInventors: Michael John ZAWOROTKO, Naga DUGGIRALA, Adam John SMITH, Roland Douglas SHYTLE
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Patent number: 9840521Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: GrantFiled: April 18, 2014Date of Patent: December 12, 2017Assignee: University of South FloridaInventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
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Publication number: 20160052941Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: ApplicationFiled: April 18, 2014Publication date: February 25, 2016Applicant: University of South FloridaInventors: Michael John ZAWOROTKO, Naga DUGGIRALA, Adam John SMITH, Roland Douglas SHYTLE
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Publication number: 20150250797Abstract: Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.Type: ApplicationFiled: November 5, 2014Publication date: September 10, 2015Inventors: Michael John ZAWOROTKO, Heather CLARK, Arora KAPILDEV, Padmini KAVURU, Roland Douglas SHYTLE, Twarita PUJARI, Lissette MARSHALL, Tien Teng ONG
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Publication number: 20140242193Abstract: 2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms.Type: ApplicationFiled: March 26, 2012Publication date: August 28, 2014Applicant: University of South FloridaInventors: Michael John Zaworotko, Roland D. Shytle, Tien Teng Ong, Padmini Kavuru, Ryan N. Cantwell, Tranhha Nguyen, Adam John Smith
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Publication number: 20130184456Abstract: A process for the preparation of a heterocyclic macrocycle-templated supramolecular metal organic material, the process comprising preparing a reaction mixture containing a metal, a heterocyclic macrocycle, and organic ligands and forming, in the reaction mixture, a heterocyclic macrocycle-templated metal organic material comprising the metal, the heterocyclic macrocycle and the ligands by template-directed synthesis with the heterocyclic macrocycle serving as the template and being encapsulated within a cage of the template metal organic material.Type: ApplicationFiled: June 20, 2012Publication date: July 18, 2013Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: Michael John ZAWOROTKO, Zhenjie Zhang, Randy W. Larsen, Mohamed Eddaoudi, Linping Zhang, Lukasz Wojtas
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Patent number: 5994365Abstract: Novel diazaanthracenes of formula wherein the dotted line in the central ring indicates that either the central ring is aromatically unsaturated, and in this case either R.sup.3 or H is absent from the 10-position and either R.sup.4 or H is absent from the 5-position, or the central ring is saturated and R.sup.3 and H and R.sup.4 and H are present, and the corresponding 5,10-diones, N-oxides, N-halides, N-amine, salts, dimers, Diels-Alder adducts, carbene adducts and complexes with transition metal compounds display valuable antibacterial, anticancer and antifungal properties. The compounds of formulae (I) and (II) in which R.sup.1 and R.sup.2 are both methyl groups can be obtained by subjecting 3,5-lutidine to the effect of a strong reducing agent, for example molten sodium.Type: GrantFiled: March 30, 1998Date of Patent: November 30, 1999Assignee: Diazans LimitedInventors: Michael John Zaworotko, Subramanian Sethuraman Iyer