Abstract: The present invention is directed to certain pyridopyrimidine and pyrimido[4,5-d]pyrimidine inhibitors of Kirsten rat sarcoma virus (KRAS) oncoproteins, and more particularly to compounds of Formula I as well as compositions comprising Formula I and methods of using the compound of Formula I for the treatment or prevention of a disease, disorder, or medical condition mediated through KRAS, especially the KRAS G12D oncoprotein.

Abstract: Presented herein are techniques for receiving a plurality of streams by an implantable component of an implantable medical device system from a plurality of wireless sources and mixing the plurality of streams to generate stimulation signals for use in stimulating a recipient of the implantable medical device system.

Abstract: A shelter system for a truck includes a platform assembly that can pivot back-and-forth between a stowed position and a deployed position. The platform assembly spans a bed of a truck when in the stowed position. The platform assembly is disposed over a cab of the truck when in the deployed position. A tent covers the platform assembly when the platform assembly is in the deployed position.

Abstract: A scanner arrangement for a temperature measurement system for measuring a temperature of a measured surface is disclosed. The scanner arrangement includes a first temperature sensor and a reference assembly. The reference assembly includes an opening including a reference surface, a second temperature sensor in contact with and for measuring the temperature of the reference surface, and a heater for heating the reference surface in accordance with control signals from a controller. The first temperature sensor has a field of view covering a portion of the measured surface and the reference surface. In embodiments, the temperature measurement system is integrated into a photo-thermal treatment unit providing a cooling air stream and laser energy, controlled by the controller. The opening and reference surface cooperate such that the reference surface is protected from direct exposure to the cooling air stream and the laser energy.

Abstract: A method of operating a gas turbine combustor includes: selectively directing fuel and a first air supply through a fuel nozzle assembly in a head end section to produce a first fuel/air mixture, which is ignited within a liner to produce combustion gases; selectively directing a second fuel/air mixture through the liner from at least one first injector disposed at a first axial location; selectively directing a third fuel/air mixture through the liner from at least one second injector disposed at a downstream, second axial location. Each of the fuel nozzle assembly, the first injector(s), and the second injector(s) receives only a respective air supply from a compressor discharge plenum. The second injector(s) receive a respective air supply that is greater than each of the respective air supplies of the fuel nozzle assembly and the first injector(s).

Abstract: One embodiment of the present invention sets forth a technique for inserting content into a media program. The technique includes determining a plurality of markers corresponding to a plurality of locations within a media program. The technique also includes for each marker included in the plurality of markers, automatically analyzing a first set of intervals within the media program that lead up to the marker and a second set of intervals within the media program that immediately follow the marker and determine a set of audio characteristics associated with the first set of intervals and the second set of intervals. The technique further includes generating a plurality of scores for the plurality of markers based on the set of audio characteristics for each marker and inserting additional content at one or more markers included in the plurality of markers based on the plurality of scores.

Abstract: A visual perception device is described. The visual perception device has corrective optics for viewing virtual and real-world content. An insert for the corrective optics is attached using a magnetic set, pins and/or a nose piece. Interchangeable nose pieces allow for height adjustments to accommodate different users. The visual perception device has pliable components to absorb forces exerted on a nose piece and a protective barrier for limiting electric shock or ingress of dirt.

Abstract: A hose assembly for use with a tankless water heater. The hose assembly includes a flexible hose, a first connector assembly, and a second connector assembly. The first connector assembly is fluidly coupled with the flexible hose and includes a first fitting. The first fitting is rotatably coupled with the first connector assembly such that the first fitting is independently rotatable relative to the flexible hose. The second connector assembly is fluidly coupled with the flexible hose opposite to the first connector assembly.

Abstract: In some aspects, the techniques described herein relate to a motor vehicle assembly, including: a roof including a recess; a rail, wherein the rail is moveable between a retracted position and a deployed position, wherein the rail is at least partially within a recess of the roof in the retracted position, wherein the rail is able to connect to an accessory arranged above the roof in the deployed position; and a joint assembly, wherein the joint assembly is configured to guide movement of the rail between the retracted position and the deployed position, wherein the joint assembly includes a first foot, a second foot, and a slotted track, and wherein the first foot and the second foot are arranged at least partially within the slotted track.

Abstract: An assembly is described for connecting a step or other components to a tow truck or other commercial truck using a sub-frame. The sub-frame includes chassis connection elements that are attached to a chassis of the truck and support elements that extend perpendicularly away from the chassis toward left and right sides of the truck so that the step, a toolbox, or other components may be attached thereto. The step is installed at a height that allows access by a user standing thereon to a bed of the truck and to any items located on the truck bed. The assembly may also include a rear bracket assembly for attaching rear fenders to the truck.

Abstract: A method of forming a forming mold screen including providing a die plate defining a plate contour and a die center point. A screen is disposed on the die plate. A retainer plate secured to the die plate defines an opening having a retainer center point substantially aligned with the die center point. The screen is disposed between the die plate and the retainer plate and substantially defines a plane. A nested punch unit inserted into the opening includes an inner punch and an outer punch disposed around the inner punch. The inner punch and the outer punch are aligned along an axis substantially aligned with the retainer center point. The screen pressed with the nested punch unit includes pressing the screen with the inner punch followed by pressing the screen with the outer punch.

Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same.

Abstract: A system that incorporates the subject disclosure may include, for example, a processor that facilitates a performance of operations. The operations may include obtaining an identification of an action to monitor during a gameplay associated with a game, storing a representation of a sliding window of the gameplay in a first storage medium, monitoring, by the system, for the identification of the action during the gameplay, detecting the identification of the action during the gameplay responsive to the monitoring, and responsive to the detecting, storing the representation of the sliding window of the gameplay in a second storage medium that is different from the first storage medium. Additional embodiments are disclosed.

Abstract: Described herein are various coupling systems to be used with storage units that are selectively coupled and decoupled. The coupling systems may be used with storage units that are stackable and/or transportable, thus allowing the storage units to function well within a large stationary environment, such as a basement, and also for a subset of the storage units to be selected and easily moved to another location.

Abstract: A thermometer configured to detect a range of temperatures of a cooking surface includes a gauge including a first indicia and a second indicia, a thermometal operably connected to the gauge, and a stationary member defining a first aperture, the gauge configured to rotate relative to the stationary member. In response to the thermometal detecting a first range of temperatures, the gauge is configured to rotate relative to the stationary member to display the first indicia through the first aperture. In response to the thermometal detecting a second range of temperatures, the gauge is configured to rotate relative to the stationary member to display the second indicia through the first aperture.

Abstract: An authentication method for use in a device and comprises monitoring a program behavior stream comprising a plurality of program observables that comprises a program observable. The method records the program observable and matches the recorded first program observable to a program model selected from a plurality of program models stored within a program store. A user model is selected from a plurality of user models stored within a user store corresponding to the program model. A user behavior stream corresponding to the program observable is monitored and a user observable contained in the user behavior stream is recorded. The user observable is correlated to the user model and an authentication state associated with the device is determined based on the correlating.

Abstract: A vehicle console has a base, a connector assembly configured to connect the base to a vehicle support, a housing supported on the base, the housing comprising a first compartment and a second compartment, a lid covering the first compartment and defining an armrest on a top surface, at least one tray for holding one or more items in position within the second compartment, and a display device supported by the housing.

Abstract: The present invention provides compounds of the formula: wherein A, B, D1, X, Y, Z, G, R1, R2, and R3a are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.