Abstract: The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.

Abstract: Methods and apparatus for creating a dual metal interconnect on a substrate. In some embodiments, a first liner of a first nitride material is deposited into at least one 1X feature and at least one wider than 1X feature, the first liner has a thickness of less than or equal to approximately 12 angstroms; a second liner of a first metal material is deposited into the at least one 1X feature and at least one wider than 1X feature; the first metal material is reflowed such that the at least one 1X feature is filled with the first metal material and the at least one wider than 1X feature remains unfilled with the first metal material; a second metal material is deposited on the first metal material, and the second metal material is reflowed such that the at least one wider than 1X feature is filled with the second metal material.

Abstract: Embodiments of systems, apparatuses and methods provide enhanced function as a service (FaaS) to users, e.g., computer developers and cloud service providers (CSPs). A computing system configured to provide such enhanced FaaS service include one or more controls architectural subsystems, software and orchestration subsystems, network and storage subsystems, and security subsystems. The computing system executes functions in response to events triggered by the users in an execution environment provided by the architectural subsystems, which represent an abstraction of execution management and shield the users from the burden of managing the execution. The software and orchestration subsystems allocate computing resources for the function execution by intelligently spinning up and down containers for function code with decreased instantiation latency and increased execution scalability while maintaining secured execution.

Abstract: A data processing apparatus includes receive circuitry that receives an indication of a trigger block of instructions.

Abstract: An Autologous fibrin is prepared extemporaneously from either a full blood sample or a prepared sample of poor platelet plasma wherein the latter is subjected to a dedicated treatment and combined isolation process performed by a removable single-use device wherein blood or plasma components are separated and subsequently treated individually to be eventually combined by the user outside the system. The system includes a platform and a removable single-use device both being designed to cooperate mechanically.

Abstract: An anchoring unit for an implantable lead includes a body, a plurality of anchoring members, and at least one connecting element coupling together at least two of the anchoring members that are positioned adjacent to one another. The body is configured and arranged for positioning along a portion of an outer surface of a lead. The body has a first end, a second end, and a longitudinal axis extending therebetween. The first end is configured and arranged for placement on the lead so that the first end is positioned more distally on the lead than the second end. Each anchoring member has a proximal end and a distal end. The proximal end of each anchoring member extends from the body and the distal end of each anchoring member anchors to patient tissue upon implantation of the anchoring unit into the patient.

Abstract: An anchoring unit for an implantable lead includes a body, a plurality of anchoring members, and at least one connecting element coupling together at least two of the anchoring members that are positioned adjacent to one another. The body is configured and arranged for positioning along a portion of an outer surface of a lead. The body has a first end, a second end, and a longitudinal axis extending therebetween. The first end is configured and arranged for placement on the lead so that the first end is positioned more distally on the lead than the second end. Each anchoring member has a proximal end and a distal end. The proximal end of each anchoring member extends from the body and the distal end of each anchoring member anchors to patient tissue upon implantation of the anchoring unit into the patient.

Abstract: An Autologous fibrin is prepared extemporaneously from either a full blood sample or a prepared sample of poor platelet plasma wherein the latter is subjected to a dedicated treatment and combined isolation process performed by a removable single-use device wherein blood or plasma components are separated and subsequently treated individually to be eventually combined by the user outside the system. The the system includes a platform and a removable single-use device both being designed to cooperate mechanically.

Abstract: An anchoring unit for an implantable lead includes a body, a plurality of anchoring members, and at least one connecting element coupling together at least two of the anchoring members that are positioned adjacent to one another. The body is configured and arranged for positioning along a portion of an outer surface of a lead. The body has a first end, a second end, and a longitudinal axis extending therebetween. The first end is configured and arranged for placement on the lead so that the first end is positioned more distally on the lead than the second end. Each anchoring member has a proximal end and a distal end. The proximal end of each anchoring member extends from the body and the distal end of each anchoring member anchors to patient tissue upon implantation of the anchoring unit into the patient.

Abstract: An internal combustion engine of a manually operated implement, having an elastic connecting duct between the engine and an air filter for vibration-decoupled bridging of a vibration gap between engine and the air filter. The elastic connecting duct has a first conduit for fuel/air mixture and a second conduit for largely fuel-free air. The first and second conduits are separate tubes having respective bores that are separated from one another over their entire lengths, the inlet of the engine is operatively connected to the air filter via the first conduit, and an air duct window of the engine is operatively connected to the air filter via the second conduit.

Abstract: An anchoring unit for an implantable lead includes a body, a plurality of anchoring members, and at least one connecting element coupling together at least two of the anchoring members that are positioned adjacent to one another. The body is configured and arranged for positioning along a portion of an outer surface of a lead. The body has a first end, a second end, and a longitudinal axis extending therebetween. The first end is configured and arranged for placement on the lead so that the first end is positioned more distally on the lead than the second end. Each anchoring member has a proximal end and a distal end. The proximal end of each anchoring member extends from the body and the distal end of each anchoring member anchors to patient tissue upon implantation of the anchoring unit into the patient.

Abstract: An internal combustion engine of a manually operated implement, having an elastic connecting duct between the engine and an air filter for vibration-decoupled bridging of a vibration gap between engine and the air filter. The elastic connecting duct has a first conduit for fuel/air mixture and a second conduit for largely fuel-free air. The first and second conduits are separate tubes having respective bores that are separated from one another over their entire lengths, the inlet of the engine is operatively connected to the air filter via the first conduit, and an air duct window of the engine is operatively connected to the air filter via the second conduit.

Abstract: A two-stroke engine has a cylinder with a combustion chamber that is delimited by a reciprocating piston that drives with a connecting rod a crankshaft rotatably supported in a crankcase. In predetermined positions of the piston, the crankcase is connected by at least one transfer channel to the combustion chamber. The two-stroke engine has a mixture channel for supplying a fuel/air mixture and an air channel that supplies substantially fuel-free air to the transfer channel. In order to provide a simple adjustment of the air channel to different two-stroke engines of a model range, a component in which the air channel is formed has a throttle member that is arranged at an end face of the component. The throttle member throttles the air flow through the air channel in at least one operating state of the two-stroke engine.

Abstract: A two-stroke engine has a cylinder in which a combustion chamber is provided. The combustion chamber is delimited by a reciprocating piston that drives with a connecting rod a crankshaft rotatably supported in a crankcase. In predetermined positions of the piston, the crankcase is connected by at least one transfer channel to the combustion chamber. The two-stroke engine has a mixture channel for supplying a fuel/air mixture and an air channel that supplies substantially fuel-free air to the transfer channel. In order to enable in a simple way an adjustment of an air channel to different two-stroke engines of a model range, at one end face of a component in which the air channel is formed a throttle member is arranged that throttles the air flow through the air channel in at least one operating state of the two-stroke engine.

Abstract: A connecting piece (1) between a carburetor (4) and an inlet channel (3) is disposed in an internal combustion engine (2) of a portable handheld motor-driven work apparatus such as a motor-driven chain saw, cutoff machine, et cetera. The connecting piece (1) serves to compensate for relative position changes between the engine (2) and the carburetor (4). The connecting piece (1) is made of elastic material and has an expansion fold (5) which functions to compensate for length changes. The length of the connecting piece can be changed from a pressed length (a) to an expanded length (b). The expansion fold (5) partitions the connecting piece (1) into a carburetor-end section (6) and into an engine-end section (7).

Abstract: A two-stroke engine (1) has a combustion chamber (3) disposed in a cylinder (2). The combustion chamber (3) is delimited by a reciprocating piston (5). The piston (5) drives a crankshaft (7) via a connecting rod (6) and the crankshaft (7) is rotatably journalled in a crankcase (4). The two-stroke engine (1) has an intake channel (8) for the supply of fuel into the crankcase (4), an outlet (13) for exhaust gases from the combustion chamber (3) and an air channel (10) for the supply of substantially fuel-free air. A throttle element (18) is mounted in the air channel (10). At pregiven positions of the piston (5), the crankcase (4) is connected via at least one transfer channel (14) to the combustion chamber (3).

Abstract: A two-stroke engine (1) has a combustion chamber (3) disposed in a cylinder (2). The combustion chamber (3) is delimited by a reciprocating piston (5). The piston (5) drives a crankshaft (7) via a connecting rod (6) and the crankshaft (7) is rotatably journalled in a crankcase (4). The two-stroke engine (1) has an intake channel (8) for the supply of fuel into the crankcase (4), an outlet (13) for exhaust gases from the combustion chamber (3) and an air channel (10) for the supply of substantially fuel-free air. A throttle element (18) is mounted in the air channel (10). At pregiven positions of the piston (5), the crankcase (4) is connected via at least one transfer channel (14) to the combustion chamber (3).

Abstract: An elastic connecting piece (1) is mounted between a carburetor (4) and an inlet channel (3) of an internal combustion engine (2). The engine (2) is especially an engine of a portable handheld motor-driven work apparatus such as a motor-driven chain saw, cutoff machine or the like. The connecting piece (1) includes a peripherally extending expansion fold (5) arranged between its ends in order to compensate for changes in length. The expansion fold (5) subdivides the connecting piece (1) into a carburetor-end section (6) and into an engine-end section (7). The annular gap (28) of the expansion fold (5) can be bridged by a seal lip (8). The connecting piece (1) includes a peripherally extending seal seat (9) of axial length (g) in the region of the expansion fold (5). The seal lip (8) can be placed in seal-tight contact with the seal seat (9) and substantially closes the expansion fold (5) fluid tight to the interior space of the connecting piece (1).

Abstract: A one-piece elastic connecting duct for disposition between any air filter and an internal combustion engine of a manually operated implement, such as a power saw, a cut-off machine, or the like, is provided. The connecting duct comprises a first conduit for fuel/air mixture, and a second conduit for largely fuel-free air.

Abstract: A disc drive having a pivot cartridge and an actuator assembly. The actuator assembly consists of an actuator body which has a bore therein to receive the pivot cartridge. The actuator body further consists of an opening which serves as a ledge to engage a biased retaining ring. The biased retaining ring couples onto the pivot cartridge and forces the pivot cartridge to contact against one side of the bore of the actuator body.