Patents by Inventor Michael Joseph Daley

Michael Joseph Daley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of fibroblast growth factors by modification of cysteine residues
    Patent number: 6010999
    Abstract: The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 4, 2000
    Assignee: American Cyanamid Company
    Inventors: Michael Joseph Daley, Brian Lee Buckwalter, Susan Mancini Cady, Hong-Ming Shieh, Peter Bohlen, Andrew P. Seddon
  • Stabilization of somatotropins and other proteins by modification of cysteine residues
    Patent number: 5951972
    Abstract: The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: September 14, 1999
    Assignee: American Cyanamid Company
    Inventors: Michael Joseph Daley, Brian Lee Buckwalter, Susan Mancini Cady, Hong-Ming Shieh, Peter Bohlen, Andrew P. Seddon
  • Method of reversing immunosuppression in vaccines
    Patent number: 5928649
    Abstract: A method of reversing or preventing immunosuppression or antigenic interference associated with combination vaccines in mammals, is disclosed. Cytokines, or cytokine inducer, are administered in conjunction with the combination vaccine. The cytokine or cytokine inducer can be administered concurrently with or subsequently to the vaccine, and can be recombinantly produced or isolated from cell culture.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 27, 1999
    Assignee: American Cyanamid Company
    Inventors: Michael Joseph Daley, Phillip Wayne Hayes