Patents by Inventor Michael Joseph Luzzio

Michael Joseph Luzzio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20250214963
    Abstract: The present invention relates to a compound of the formula I Wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: July 30, 2024
    Publication date: July 3, 2025
    Inventors: Michael Joseph Luzzio, Kevin Daniel Freeman-Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson
  • 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF
    Publication number: 20250154111
    Abstract: Provided dihydroquinazolinone and azadihydroquinazolinone compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.
    Type: Application
    Filed: September 11, 2024
    Publication date: May 15, 2025
    Inventors: Natalie Anne Hawryluk, Stephen Thomas Schlachter, Marc Justin Evanchik, Carlos Luis Del Rio, Alan James Russell, Kevin Koch, Michael Mark DuVall, Michael Joseph Luzzio
  • QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF
    Publication number: 20250026740
    Abstract: The present disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (II-A), (IV), or (III) and pharmaceutical compositions thereof. The substituted quinolinone amide compounds or salts of Formula (I), (II-A), (IV), or (III) disclosed herein may be used to treat or prevent cardiac disease in an individual in need thereof.
    Type: Application
    Filed: September 11, 2024
    Publication date: January 23, 2025
    Inventors: Natalie Anne Hawryluk, Stephen Thomas Schlachter, Kevin Koch, Michael Joseph Luzzio, Alan James Russell, Marc Justin Evanchik, Carlos Luis Del Rio
  • QUINAZOLINONE DIONE COMPOUNDS AND USES THEREOF
    Publication number: 20250026726
    Abstract: Provided are quinazolinone dione compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.
    Type: Application
    Filed: September 11, 2024
    Publication date: January 23, 2025
    Inventors: Natalie Anne Hawryluk, Stephen Thomas Schlachter, Kevin Koch, Michael Joseph Luzzio, Michael Mark DuVall, Alan James Russell, Marc Justin Evanchik
  • PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20240308979
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Application
    Filed: October 9, 2023
    Publication date: September 19, 2024
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20240109862
    Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: March 15, 2023
    Publication date: April 4, 2024
    Inventors: Michael Joseph Luzzio, Kevin Daniel Freeman-Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson
  • Protein kinase C inhibitors and methods of their use
    Patent number: 11505541
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: November 22, 2022
    Assignee: Novartis AG
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20220251066
    Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: August 27, 2021
    Publication date: August 11, 2022
    Inventors: Michael Joseph Luzzio, Kevin Daniel Freeman-Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson
  • PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20210387962
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Application
    Filed: March 12, 2021
    Publication date: December 16, 2021
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • Protein kinase C inhibitors and methods of their use
    Patent number: 11059804
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: July 13, 2021
    Assignee: Novartis AG
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20200262814
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Application
    Filed: October 28, 2019
    Publication date: August 20, 2020
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20200002310
    Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: September 11, 2019
    Publication date: January 2, 2020
    Inventors: Michael Joseph Luzzio, Kevin Daniel Freeman-Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson
  • Protein kinase C inhibitors and methods of their use
    Patent number: 10508101
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: December 17, 2019
    Assignee: NOVARTIS AG
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20190202809
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 4, 2019
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20180179181
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Application
    Filed: December 4, 2017
    Publication date: June 28, 2018
    Inventors: Michael Joseph LUZZIO, Julien PAPILLON, Michael Scott VISSER
  • Protein kinase C inhibitors and methods of their use
    Patent number: 9845309
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: December 19, 2017
    Assignee: NOVARTIS AG
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20170001981
    Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: September 12, 2016
    Publication date: January 5, 2017
    Inventors: Michael Joseph Luzzio, Kevin Daniel Freeman-Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson
  • PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20160347737
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Application
    Filed: August 16, 2016
    Publication date: December 1, 2016
    Applicant: NOVARTIS AG
    Inventors: Michael Joseph LUZZIO, Julien PAPILLON, Michael Scott VISSER
  • Protein kinase C inhibitors and methods of their use
    Patent number: 9452998
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: September 27, 2016
    Assignee: NOVARTIS AG
    Inventors: Michael Scott Visser, Michael Joseph Luzzio, Julien Papillon
  • SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20160130250
    Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: January 19, 2016
    Publication date: May 12, 2016
    Inventors: Michael Joseph Luzzio, Kevin Daniel Freeman-Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson