Patents by Inventor Michael Joseph McLean

Michael Joseph McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homocyclic and heterocyclic compounds suitable for use in oligonucleotide synthesis
    Patent number: 5886193
    Abstract: A support carrying a homocyclic or heterocyclic ring containing a first and second carbon atom wherein: (i) the first carbon atom is substituted by a nucleophilic group or a group convertible to a nucleophilic group on treatment with base; (ii) the second carbon atom is substituted by a hydroxy group, a hydroxy group protected by an acid labile protecting group, or a phosphate group substituted by an oligonucleotide; and (iii) the first and second carbon atoms are directly connected by a covalent bond; which is suitable for use in oligonucleotide synthesis. Methods for its preparation and use, and novel compounds for attachment to the support are described.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: March 23, 1999
    Assignee: Zeneca Limited
    Inventors: Michael Joseph McLean, Andrew John Garman
  • Compounds
    Patent number: 5681945
    Abstract: A support carrying a homocyclic or heterocyclic ring containing a first and second carbon atom wherein: (i) the first carbon atom is substituted by a nucleophilic group or a group convertible to a nucleophilic group on treatment with base; (ii) the second carbon atom is substituted by a hydroxy group, a hydroxy group protected by an acid labile protecting group, or a phosphate group substituted by an oligonucleotide; and (iii) the first and second carbon atoms are directly connected by a covalent bond; which is suitable for use in oligonucleotide synthesis. Methods for its preparation and use, and novel compounds for attachment to the support are described.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: October 28, 1997
    Assignee: Zeneca Limited
    Inventors: Michael Joseph McLean, Andrew John Garman