Patents by Inventor Michael Joseph Roth

Michael Joseph Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the manufacture of Anagrelide
    Patent number: 6653500
    Abstract: Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: November 25, 2003
    Assignee: Shire US Inc.
    Inventors: Philip C. Lang, Roxanne P. Spencer, Wen-Lung Yeh, Michael Joseph Roth
  • Synthesis of histamine dihydrochloride
    Patent number: 6620942
    Abstract: The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: September 16, 2003
    Assignee: Maxim Pharmaceuticals
    Inventors: Wen-Lung Yeh, Casimir Antczak, Jeffry David McGolrick, Michael Joseph Roth, Mark Wrona
  • SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE
    Publication number: 20030138964
    Abstract: The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
    Type: Application
    Filed: February 10, 2003
    Publication date: July 24, 2003
    Inventors: Wen-Lung Yeh, Casimir Antczak, Jeffry David McGolrick, Michael Joseph Roth, Mark Wrona
  • Method for the manufacture of Anagrelide
    Publication number: 20030060630
    Abstract: Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
    Type: Application
    Filed: April 25, 2002
    Publication date: March 27, 2003
    Applicant: Shire US Inc.
    Inventors: Philip C. Lang, Roxanne P. Spencer, Wen-Lung Yeh, Michael Joseph Roth
  • Synthesis of histamine dihydrochloride
    Patent number: 6528654
    Abstract: The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: March 4, 2003
    Assignee: Maxim Pharmaceuticals, Inc.
    Inventors: Wen-Lung Yeh, Casimir Antczak, Jeffry David McGolrick, Michael Joseph Roth, Mark Wrona
  • Synthesis of histamine dihydrochloride
    Patent number: 6403806
    Abstract: The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: June 11, 2002
    Assignee: Maxim Pharmaceuticals, Inc.
    Inventors: Wen-Lung Yeh, Casimir Antczak, Jeffry David McGolrick, Michael Joseph Roth, Mark Wrona
  • Method for the manufacture of anagrelide
    Patent number: 6388073
    Abstract: Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: May 14, 2002
    Assignee: Shire US Inc.
    Inventors: Philip C. Lang, Roxanne P. Spencer, Wen-Lung Yeh, Michael Joseph Roth
  • Synthesis of histamine dihydrochloride
    Publication number: 20020035268
    Abstract: The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
    Type: Application
    Filed: October 9, 2001
    Publication date: March 21, 2002
    Inventors: Wen-Lung Yeh, Casimir Antczak, Jeffrey David McGolrick, Michael Joseph Roth, Mark Wrona