Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof for use in the treatment or for use in alleviating the symptoms of an NLRC4 inflammasomopathy, such as an NLRC4-GOF inflammasomopathy in a subject in need thereof. This invention also relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof for use in the treatment or for use in alleviating the symptoms of AIFEC in a subject in need thereof.

Abstract: The present invention relates to an assembly of switching layers for dimming and scattering of light and to window elements comprising the arrangement of switching layers.

Abstract: A glazing (10) comprising a switchable optical device (26) is proposed. The switchable optical device (26) has a layer structure comprising in this order a first substrate (12), a switchable layer (18) and a second substrate (24). Further, at least one of the first substrate (12) and the second substrate (24) is attached to a further sheet (30) by means of an adhesive tape (40) or an optically clear adhesive (48). Further aspects of the invention relate to a laminated structure and an insulated glazing unit comprising such a glazing (10) and a method for manufacturing of such a glazing (10).

Abstract: A switchable window element (10) having a layer structure is proposed. The layer structure comprises a switchable layer (20), two polarizers and two optical retarders, wherein a first polarizer and a first optical retarder are arranged in an optical path (40) prior to the switchable layer (20) and a second polarizer and a second optical retarder are arranged in the optical path (40) after the switchable layer (20). Further, the switchable layer (20) is a vertically aligned liquid crystal layer comprising a liquid crystalline medium, wherein the product of the thickness d of the switchable layer (20) and the optical anisotropy ?n of the liquid crystalline medium is in the range of from 0.05 ?m to 3.0 ?m and the liquid crystalline medium has a clearing point of at least 70° C. Further aspects of the invention relate to the use of the switchable window element as window for a building or a vehicle.

Abstract: The present invention relates to liquid crystalline media comprising one or more benzothiadiazol derivatives of formula I, in which R11, R12, A11, A12, A21, A22, Z11, Z12, Z21, Z22, W, X11, X12, r and s have the meanings indicated in claim 1, to the use of such liquid crystal media for optical, electro-optical and electronic purposes, in particular in devices for regulating the passage of energy from an outside space into an inside space, for example in windows.

Abstract: The present invention relates to benzotriazole derivatives selected from the group of compounds of formulae Ia, Ib and Ic as defined in claim 1, to mesogenic media comprising the compounds of formulae Ia, Ib and Ic, and to the use of these compounds and mesogenic media in optical, electronic and electro-optical applications, in particular in devices for regulating the passage of energy from an outside space into an inside space, for example in windows.

Abstract: Devices for the regulation of light transmission and in particular switchable windows, including window elements containing a switchable optical cell having a homeotropically aligned liquid crystal layer with a pretilt angle in the range of 77° to 88°.

Abstract: The present invention relates to liquid-crystalline media comprising one or more mesogenic compounds, one or more chiral compounds, and one or more polymerisable mesogenic compounds, wherein the media exhibit a pitch of 0.55 ?m or more and a clearing point of 80° C. or more and wherein the one or more polymerisable mesogenic compounds are contained in an amount, based on the overall contents of the media, of 5% by weight or less. The present invention further relates to modulation materials obtainable from the media and to switching layers and window elements containing the materials.

Abstract: The present invention relates to liquid-crystalline media comprising one or more mesogenic compounds of formula I as set forth hereinafter, wherein the one or more compounds of formula I are contained in the medium in an amount, based on the overall contents of the medium, of at least 15% by weight. The present invention further relates to a switching layer, a switching element and a window element containing the liquid-crystalline medium.

Abstract: The present application relates to a liquid-crystalline material comprising a sterically hindered N-oxide and a dye. The invention furthermore relates to the use of the liquid-crystalline material in an optical switching device for regulation of the passage of sunlight.

Abstract: The present invention relates to liquid crystalline media comprising one or more naphthothiadiazol derivatives of formula I, in which R11, R12, A11, A12, A21, A22, Z11, Z12, Z21, Z22, W, X11, X12, L, r, s and t have the meanings indicated in claim 1, to the use of such liquid crystal media for optical, electro-optical and electronic purposes, in particular in devices for regulating the passage of energy from an outside space into an inside space, for example in windows.

Abstract: Novel dithiopyrrolopyrrole derivatives having dichroic properties which have very high photostability in solution in a liquid-crystalline host are proposed.

Abstract: The invention relates to a blade for a turbomachine, comprising a blade element with a suction side and a pressure side, which extend between a leading edge and a trailing edge of the blade element, as well as a blade root for connection of the blade at a main rotor body, wherein the blade comprises a crack-affecting device, which, in the radial direction, has an altered cross-sectional geometry in comparison to an aerodynamically optimized blade profile. The invention further relates to a rotor for a turbomachine having at least one such blade, a turbomachine having at least one such blade, and/or with such a rotor as well as a method for producing a blade.

Abstract: The present application relates to a liquid-crystalline material comprising a sterically hindered N-oxide and a dye. The invention furthermore relates to the use of the liquid-crystalline material in an optical switching device for regulation of the passage of sunlight.

Abstract: The present invention relates to thiadiazoloquinoxaline derivatives of the formula I, in which R11, R12, A11, A12, A21, A22, Z11, Z12, Z21, Z22, W, X11, X12, r and s have the meanings indicated in Claim 1, to processes and intermediates for the preparation thereof, to the use of the compounds of the formula I for optical, electro-optical and electronic purposes, in particular in liquid-crystal media and in devices for regulating the passage of energy from an outside space into an inside space, and to these LC media and the devices comprising these media.

Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising one or more compounds of the formula I, and one or more compounds selected from the group of the compounds of the formulae II and III and/or IV, in which the parameters have the respective meanings indicated in the specification, and optionally one or more further dielectrically positive compounds and optionally one or more further dielectrically neutral compounds, and to liquid-crystal displays, especially active-matrix displays and in particular TN, IPS and FFS displays, containing these media.

Abstract: The present application relates to mixtures which have liquid-crystalline properties. The application furthermore relates to the use of the mixtures in devices which regulate the transmission of light through an area element.

Abstract: The application relates to a device for regulating the entry of light into a room, which comprises a switchable layer of specific design comprising a twisted nematic liquid-crystalline medium and a dichroic compound.

Abstract: The present application relates to a device for regulating the passage of light which is characterised in that it comprises a layer comprising a liquid-crystalline mixture containing a characteristic structural element.

Abstract: An optical switching device comprising a polarisation layer and a switching layer which comprises a liquid-crystalline material and a dye compound. Use of the optical switching device for the regulation of the passage of light through an area element. A window element which has the optical switching device therein.