Patents by Inventor Michael K. Ameriks

Michael K. Ameriks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZOPYRAZINES AND PYRAZOLOPYRIMIDINES AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180118751
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).
    Type: Application
    Filed: April 28, 2016
    Publication date: May 3, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Bradley M. Savall, Devin M. Swanson, Dongpei Wu
  • INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180118683
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).
    Type: Application
    Filed: April 28, 2016
    Publication date: May 3, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Suchitra Ravula, Bradley M. Savall, Devin M. Swanson, Jeannie M. Ziff, Brock T. Shireman
  • 3-ARYL-2H-PYRAZOLO[4,3-b]PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180111925
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Brian Ngo Laforteza, Brad M. Savall, Warren Stanfield Wade, Stephen Todd Meyer, Márió Gyuris
  • FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180111942
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Brian Ngo Laforteza, Terry Patrick Lebold, Suchitra Ravula, Brad M. Savall, Brock T. Shireman
  • FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180111933
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Márió Gyuris, Brian Ngo Laforteza, Terry Patrick Lebold, Stephen Todd Meyer, Suchitra Ravula, Brad M. Savall, Brock T. Shireman, Warren Stanfield Wade, János Gerencsér
  • P2X7 MODULATORS
    Publication number: 20160016962
    Abstract: The present invention is directed to a compound of Formula (I) Formula (I) The invention also relates to pharmaceutical compositions comprising compounds of Formula (I) and methods comprising administering to a subject at least one compound selected from compounds of Formula (I) for treating diseases mediated by P2X7 receptor activity, such as rheumatoid arthritis, osteoarthritis, psoriasis, septic shock, allergic dermatitis, asthma, allergic asthma, mild to severe asthma, steroid resistant asthma, idiopathic pulmonary fibrosis, allergic rhinitis, chronic obstructive pulmonary disease; airway hyper-responsiveness, diseases of the nervous and neuro-immune system, acute and chronic pain states of neuropathic pain, inflammatory pain, spontaneous pain, opioid induced pain, diabetic neuropathy, postherpetic neuralgia, low back pain, chemotherapy-induced neuropathic pain, fibromyalgia, diseases involved with and without neuroinflammation of the central nervous system, mood disorders, major depression, major depress
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Inventors: Michael K. Ameriks, Jason C. Rech, Brad M. Savall, Jessica L. WALL
  • [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS P2X7 MODULATORS
    Publication number: 20150290190
    Abstract: The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
    Type: Application
    Filed: April 21, 2015
    Publication date: October 15, 2015
    Inventors: Michael K. Ameriks, Jason C. Rech, Brad M. Savall
  • [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
    Patent number: 9040534
    Abstract: The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 26, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Jason C. Rech, Brad M. Savall
  • P2X7 MODULATORS
    Publication number: 20140275096
    Abstract: The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Jason C. Rech, Brad M. Savall
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Patent number: 7687639
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: March 30, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael K. Ameriks, Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher
  • MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
    Publication number: 20090118274
    Abstract: Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: May 7, 2009
    Inventors: Darin Allen, Michael K. Ameriks, Frank U. Axe, Matthew Burdett, Hui Cai, Ingrid Choong, James P. Edwards, Willard Lew, Steven P. Meduna
  • TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S
    Publication number: 20090099157
    Abstract: Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: April 16, 2009
    Inventors: Michael K. Ameriks, Kristen L. Arienti, James P. Edwards, Cheryl A. Grice, Todd K. Jones, Alice Lee-Dutra, Jing Liu, Neelakandha S. Mani, Danielle K. Neff, Alvah T. Wickboldt, John J.M. Wiener
  • BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
    Publication number: 20080269241
    Abstract: Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: October 30, 2008
    Inventors: Darin Allen, Michael K. Ameriks, Frank U. Axe, Matthew Burdett, Hui Cai, Ingrid Choong, James P. Edwards, Willard Lew, Steven P. Meduna
  • CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
    Publication number: 20080200454
    Abstract: Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: August 21, 2008
    Inventors: Michael K. Ameriks, Frank U. Axe, James P. Edwards, Cheryl A. Grice, Hui Cai, Elizabeth Ann Gleason, Steven P. Meduna, Kevin L. Tays, John J. M. Wiener, Alvah T. Wickboldt
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Patent number: 7132440
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: November 7, 2006
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Michael K. Ameriks, Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Publication number: 20040214857
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Application
    Filed: April 16, 2004
    Publication date: October 28, 2004
    Inventors: Michael K. Ameriks, Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher