Abstract: The present invention relates to compounds of Formula (I) that may act as inhibitors of checkpoint kinase 1 (Chk1). The invention also relates to pharmaceutical compositions comprising those compounds, and to their use in the treatment of disease and conditions susceptible to Chk1 inhibition, such as cancer.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: One aspect of the invention is a method for the electronic design of collaborative and validated architectures. The method for the electronic design of an architecture includes storing architecture elements created by users in a centralized database. The creation of an architecture model is initiated in response to a request of a user of a client system. The centralized database is accessed to retrieve the architecture elements and a selection of an architecture element for inclusion in the architecture model is received from the user. The architecture model including the selected architecture element is included in the centralized database.

Abstract: An apparatus for dispensing a controlled dose of a substance wherein the apparatus includes a compressible tube portion, a tip portion extending from the tube portion sized to receive a substance to be dosed, and a breakaway portion being removably coupled to the tip portion. The breakaway portion reveals an aperture in the tip portion upon removal of the breakaway portion. Finally, a valve member is slidably disposed in the tip portion such that the valve member can be movable in response to fluid pressure and/or manual force application to urge the substance within the tip portion out of the aperture as a controlled dose.

Abstract: One aspect of the invention is a method for the electronic design of collaborative and validated architectures. The method for the electronic design of an architecture includes storing architecture elements created by users in a centralized database. The creation of an architecture model is initiated in response to a request of a user of a client system. The centralized database is accessed to retrieve the architecture elements and a selection of an architecture element for inclusion in the architecture model is received from the user. The architecture model including the selected architecture element is included in the centralized database.

Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.

Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.