Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a plurality of absorbable filaments arranged in a support structure and configured degrade within a defined time period and a membrane arranged about the plurality of absorbable filaments and configured to contain fragments of the plurality of absorbable filaments in response to a fracture or degradation of a filament.

Abstract: Amniotic fluid stem cell clones are provided. Also provided are pharmaceutical compositions comprising the amniotic fluid stem cell clones, methods of generating the amniotic fluid stem cell clones, and methods of using the amniotic fluid stem cell clones, including for treating subjects and for bioassays.

Abstract: Homogeneous human amniotic fluid stem cell clones are provided. The clones serve as direct bioassays to test the effect of drugs, nutraceuticals, vitamins and toxic agents on fetus growth, differentiation and development, and may be administered in form of pharmaceutical compositions for reconstructive engineering and for the treatment of cardiac, neurological and osteoarthritic diseases.

Abstract: Several different pyrrolysine analogs are disclosed in this application. Those analogs have distinct chemical and biophysical properties. Some analogs are useful in chemical ligation applications. Methods of making and using are also disclosed.

Abstract: In one example, a device includes a display, an interface configured to exchange data with external devices, a control unit configured to execute an application to cause the display to display a current visual representation of the application, determine a current application state of the application, wherein the current application state includes at least a portion of the current visual representation of the application, and means for sending, without user intervention, an indication of the determined current application state from the device to a second, different device via the interface, wherein the indication of the determined current application state comprises information for recreating at least the portion of the current visual representation of the application, wherein the control unit is configured to prevent subsequent indications of the current application state from being sent to the second device in response to an indication that a third device is executing the application.

Abstract: In general, the present disclosure is directed to techniques for displaying, e.g., events of multiple calendars or annotations in a word processor in a single view. In one example, a method includes, providing a first calendar and a second calendar, wherein the first calendar includes a first group of calendar events at least some of which have corresponding textual event details, and wherein the second calendar includes a second group of calendar events at least some of which have corresponding textual event details; receiving a user input to select one of the first calendar or the second calendar; displaying the one or more corresponding textual event details of the first group of calendar events for the first calendar; and displaying visual representations of the second group of calendar events for the second calendar without displaying the corresponding textual event details.

Abstract: In general, the present disclosure is directed to techniques for displaying, e.g., events of multiple calendars or annotations in a word processor in a single view. In one example, a method includes, providing a first calendar and a second calendar, wherein the first calendar includes a first group of calendar events at least some of which have corresponding textual event details, and wherein the second calendar includes a second group of calendar events at least some of which have corresponding textual event details; receiving a user input to select one of the first calendar or the second calendar; displaying the one or more corresponding textual event details of the first group of calendar events for the first calendar; and displaying visual representations of the second group of calendar events for the second calendar without displaying the corresponding textual event details.

Abstract: Several different pyrrolysine analogs are disclosed in this application. Those analogs have distinct chemical and biophysical properties. Some analogs are useful in chemical ligation applications. Methods of making and using are also disclosed.

Abstract: In general, the present disclosure is directed to techniques for displaying, e.g., events of multiple calendars or annotations in a word processor in a single view. In one example, a method includes, providing a first calendar and a second calendar, wherein the first calendar includes a first group of calendar events at least some of which have corresponding textual event details, and wherein the second calendar includes a second group of calendar events at least some of which have corresponding textual event details; receiving a user input to select one of the first calendar or the second calendar; displaying the one or more corresponding textual event details of the first group of calendar events for the first calendar; and displaying visual representations of the second group of calendar events for the second calendar without displaying the corresponding textual event details.

Abstract: In one example, a device includes a display, an interface configured to exchange data with external devices, a control unit configured to execute an application to cause the display to display a current visual representation of the application, determine a current application state of the application, wherein the current application state includes at least a portion of the current visual representation of the application, and means for sending, without user intervention, an indication of the determined current application state from the device to a second, different device via the interface, wherein the indication of the determined current application state comprises information for recreating at least the portion of the current visual representation of the application, wherein the control unit is configured to prevent subsequent indications of the current application state from being sent to the second device in response to an indication that a third device is executing the application.

Abstract: In general, the subject matter described in this specification can be embodied in methods, systems, and program products. A mobile computing device that is physically contacting a docking system receives one or more electrical signals via a physical electrical connection between the mobile computing device and the docking system. The mobile computing device identifies, based on the received one or more electrical signals, a type of the docking system. The mobile computing device determines, based on having identified the type of the docking system, that a setting for automatically establishing wireless communication between the mobile computing device and the docking system is activated. The mobile computing device establishes, as a result of determining that the setting is activated, the wireless communication between the mobile computing device and the docking system.

Abstract: In general, the present disclosure is directed to techniques for displaying, e.g., events of multiple calendars or annotations in a word processor in a single view. In one example, a method includes, providing a first calendar and a second calendar, wherein the first calendar includes a first group of calendar events at least some of which have corresponding textual event details, and wherein the second calendar includes a second group of calendar events at least some of which have corresponding textual event details; receiving a user input to select one of the first calendar or the second calendar; displaying the one or more corresponding textual event details of the first group of calendar events for the first calendar; and displaying visual representations of the second group of calendar events for the second calendar without displaying the corresponding textual event details.

Abstract: In one example, a device includes a display, an interface configured to exchange data with external devices, a control unit configured to execute an application to cause the display to display a current visual representation of the application, determine a current application state of the application, wherein the current application state includes at least a portion of the current visual representation of the application, and means for sending, without user intervention, an indication of the determined current application state from the device to a second, different device via the interface, wherein the indication of the determined current application state comprises information for recreating at least the portion of the current visual representation of the application, wherein the control unit is configured to prevent subsequent indications of the current application state from being sent to the second device in response to an indication that a third device is executing the application.

Abstract: In general, the subject matter described in this specification can be embodied in methods, system and program products. A mobile computing device determines that the mobile computing device has physically paired with a docking system. Wireless communication between the mobile computing device and the docking system is automatically established in response to said determining that the mobile computing device has physically paired with the docking system. Data that encodes an audio signal is transmitted, by the mobile computing device and to the docking system as part of the wireless communication, so as to cause speakers of the docking system to audibly output the audio signal from the mobile computing device.

Abstract: In general, the subject matter described in this specification can be embodied in methods, system and program products. A mobile computing device determines that the mobile computing device has physically paired with a docking system. Wireless communication between the mobile computing device and the docking system is automatically established in response to said determining that the mobile computing device has physically paired with the docking system. Data that encodes an audio signal is transmitted, by the mobile computing device and to the docking system as part of the wireless communication, so as to cause speakers of the docking system to audibly output the audio signal from the mobile computing device.

Abstract: In general, the subject matter described in this specification can be embodied in methods, systems, and program products. A mobile computing device is determined to have electrically coupled by physical contact with a docking system that is adapted to supply electrical power for charging the mobile computing device. The docking system is determined to be a first type of docking system from a plurality of types of docking systems. A first user interface profile that corresponds to the first type of docking system is selected from among a plurality of user interface profiles. Each of the plurality of user interface profiles corresponds to a respective type of docking system from the plurality of types of docking systems. The first user interface profile is presented by the mobile computing device in response to selection of the first user interface profile.

Abstract: In general, the subject matter described in this specification can be embodied in methods, systems, and program products. A mobile computing device is determined to have electrically coupled by physical contact with a docking system that is adapted to supply electrical power for charging the mobile computing device. The docking system is determined to be a first type of docking system from a plurality of types of docking systems. A first user interface profile that corresponds to the first type of docking system is selected from among a plurality of user interface profiles. Each of the plurality of user interface profiles corresponds to a respective type of docking system from the plurality of types of docking systems. The first user interface profile is presented by the mobile computing device in response to selection of the first user interface profile.

Abstract: In general, the present disclosure is directed to techniques for displaying, e.g., events of multiple calendars or annotations in a word processor in a single view. In one example, a method includes, providing a first calendar and a second calendar, wherein the first calendar includes a first group of calendar events at least some of which have corresponding textual event details, and wherein the second calendar includes a second group of calendar events at least some of which have corresponding textual event details; receiving a user input to select one of the first calendar or the second calendar; displaying the one or more corresponding textual event details of the first group of calendar events for the first calendar; and displaying visual representations of the second group of calendar events for the second calendar without displaying the corresponding textual event details.

Abstract: In general, the present disclosure is directed to techniques for displaying, e.g., events of multiple calendars or annotations in a word processor in a single view. In one example, a method includes, providing a first calendar and a second calendar, wherein the first calendar includes a first group of calendar events at least some of which have corresponding textual event details, and wherein the second calendar includes a second group of calendar events at least some of which have corresponding textual event details; receiving a user input to select one of the first calendar or the second calendar; displaying the one or more corresponding textual event details of the first group of calendar events for the first calendar; and displaying visual representations of the second group of calendar events for the second calendar without displaying the corresponding textual event details.