Patents by Inventor Michael K. Cooper

Michael K. Cooper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 9427431
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: August 30, 2016
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Michael K. Cooper, Jefferey A. Porter
  • INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20120183603
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
    Type: Application
    Filed: February 1, 2012
    Publication date: July 19, 2012
    Inventors: Philip A. BEACHY, Michael K. Cooper, Jeffrey A. Porter
  • Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 8097632
    Abstract: The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: January 17, 2012
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Jeffery A. Porter, Michael K. Cooper
  • Cholesterol and hedgehog signaling
    Patent number: 8076073
    Abstract: The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: December 13, 2011
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Jeffrey A. Porter, Michael K. Cooper
  • INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20100273818
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
    Type: Application
    Filed: January 5, 2010
    Publication date: October 28, 2010
    Applicant: JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Philip A. Beachy, Michael K. Cooper, Jeffrey A. Porter
  • Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 7291626
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: November 6, 2007
    Assignee: John Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Michael K. Cooper, Jeffrey A. Porter
  • Inhibitors of hedgehog signal pathways, compositions and uses related thereto
    Patent number: 6867216
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: March 15, 2005
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Michael K. Cooper, Jeffrey A. Porter
  • Cholesterol and hedgehog signaling
    Publication number: 20030207853
    Abstract: The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
    Type: Application
    Filed: May 20, 2003
    Publication date: November 6, 2003
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Philip A. Beachy, Jeffrey A. Porter, Michael K. Cooper
  • Cholesterol and hedgehog signaling
    Publication number: 20030203885
    Abstract: The present invention sterol-modified hedgehog polypeptides and functional fragments thereof Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
    Type: Application
    Filed: May 19, 2003
    Publication date: October 30, 2003
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Philip A. Beachy, Jeffrey A. Porter, Michael K. Cooper
  • Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 6432970
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein comprising contacting a cell sensitive to the hedgehog protein with a steroidal alkaloid, or other small molecule, in a sufficient amount to reduce the sensitivity of the cell to the hedgehog protein.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: August 13, 2002
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Michael K. Cooper, Jeffrey A. Porter
  • Cholesterol and hedgehog signaling
    Publication number: 20020045607
    Abstract: The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
    Type: Application
    Filed: September 11, 2001
    Publication date: April 18, 2002
    Applicant: The Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Jeffrey A. Porter, Michael K. Cooper
  • INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20020006931
    Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein comprising contacting a cell sensitive to the hedgehog protein with a steroidal alkaloid, or other small molecule, in a sufficient amount to reduce the sensitivity of the cell to the hedgehog protein.
    Type: Application
    Filed: June 4, 1998
    Publication date: January 17, 2002
    Inventors: PHILIP A. BEACHY, MICHAEL K. COOPER, JEFFREY A. PORTER
  • Cholesterol and hedgehog signaling
    Patent number: 6288048
    Abstract: The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: September 11, 2001
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Jeffrey A. Porter, Michael K. Cooper