Patents by Inventor Michael K. George
Michael K. George has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132578Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: ApplicationFiled: August 18, 2023Publication date: April 25, 2024Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Majorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
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Patent number: 10183193Abstract: A fitness monitor comprises a housing, a wrist band, a motion sensor, a display, a non-transitory memory element and a processing element. The wrist band is coupled to the housing and configured to attach to a wrist of a user. The motion sensor is configured to sense motion of the user and generate motion data. The display is coupled to the housing and configured to present information associated with user activity. The memory element is located in the housing and configured to store the activity data and a daily activity goal. The processing element is operably coupled to the memory element and configured to determine daily activity data, a daily activity goal corresponding to a predetermined level of activity for the user, compute an activity countdown and level of inactivity, and present, on the display, the activity countdown and inactivity indicia indicating the level of inactivity.Type: GrantFiled: February 18, 2016Date of Patent: January 22, 2019Assignee: Garmin Switzerland GmbHInventors: Wai C. Lee, Michael K. George, Andrew J. Skarsgard
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Publication number: 20160158602Abstract: A fitness monitor comprises a housing, a wrist band, a motion sensor, a display, a non-transitory memory element and a processing element. The wrist band is coupled to the housing and configured to attach to a wrist of a user. The motion sensor is configured to sense motion of the user and generate motion data. The display is coupled to the housing and configured to present information associated with user activity. The memory element is located in the housing and configured to store the activity data and a daily activity goal. The processing element is operably coupled to the memory element and configured to determine daily activity data, a daily activity goal corresponding to a predetermined level of activity for the user, compute an activity countdown and level of inactivity, and present, on the display, the activity countdown and inactivity indicia indicating the level of inactivity.Type: ApplicationFiled: February 18, 2016Publication date: June 9, 2016Inventors: Wai C. Lee, Michael K. George, Andrew J. Skarsgard
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Patent number: 9295413Abstract: A fitness monitor comprises a housing, a wrist band, a motion sensor, a display, a non-transitory memory element and a processing element. The wrist band is coupled to the housing and configured to attach to a wrist of a user. The motion sensor is configured to sense motion of the user and generate motion data. The display is coupled to the housing and configured to present information associated with user activity. The memory element is located in the housing and configured to store the activity data and a daily activity goal. The processing element is operably coupled to the memory element and configured to determine daily activity data, a daily activity goal corresponding to a predetermined level of activity for the user, compute an activity countdown and level of inactivity, and present, on the display, the activity countdown and inactivity indicia indicating the level of inactivity.Type: GrantFiled: September 11, 2013Date of Patent: March 29, 2016Assignee: Garmin Switzerland GmbHInventors: Wai C. Lee, Michael K. George, Andrew J. Skarsgard
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Publication number: 20140200691Abstract: A fitness monitor comprises a housing, a wrist band, a motion sensor, a display, a non-transitory memory element and a processing element. The wrist band is coupled to the housing and configured to attach to a wrist of a user. The motion sensor is configured to sense motion of the user and generate motion data. The display is coupled to the housing and configured to present information associated with user activity. The memory element is located in the housing and configured to store the activity data and a daily activity goal. The processing element is operably coupled to the memory element and configured to determine daily activity data, a daily activity goal corresponding to a predetermined level of activity for the user, compute an activity countdown and level of inactivity, and present, on the display, the activity countdown and inactivity indicia indicating the level of inactivity.Type: ApplicationFiled: September 11, 2013Publication date: July 17, 2014Applicant: Garmin Switzerland GmbHInventors: Wai C. Lee, Michael K. George, Andrew J. Skarsgard
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Patent number: 6472485Abstract: A process for the preparation of a thermoplastic resin, or thermoplastic resins comprising: forming, or providing a miniemulsion comprised of a mixture of an oligomeric compound of the formula R-SFR, wherein R is an oligomeric compound comprised of from about 1 to about 30 monomer units and optionally a covalently bonded free radical initiator compound, -SFR is a covalently bound stable free radical end group, and at least one free radical polymerizable monomer compound, and a surfactant; and heating the miniemulsion wherein there results a latex thermoplastic resin or a latex of thermoplastic resins with a high monomer to polymer conversion of about 85 to about 100 percent and a narrow polydispersity of from about 1.1 to about 2.0.Type: GrantFiled: October 12, 2001Date of Patent: October 29, 2002Assignee: Xerox CorporationInventors: Paula J. MacLeod, Peter G. Odell, Francisco E. Torres, Michael K. Georges
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Patent number: 6469094Abstract: A process for latex preparation including: a first heating of a mixture of at least one free radical polymerizable monomer compound, a free radical initiator compound, and a stable free radical compound to form a latomer mixture with from about 1 to about 8 percent conversion of the monomer compound to an oligomeric compound of the formula I—R′—SFR, wherein R′ is an oligomer comprised of from about 1 to about 30 monomer units, I— is a covalently bonded free radical initiator fragment arising from the free radical initiator compound, and —SFR is a covalently bound stable free radical group; dispersing the resulting latomer mixture in water with high shear to form a miniemulsion; and a second heating of the miniemulsion, wherein there results a high stability polymer particle latex which contains a polymer with a high monomer to polymer conversion of from about 98 to about 100 weight percent and a narrow polydispersity of from about 1.1 to about 2.0.Type: GrantFiled: April 28, 2000Date of Patent: October 22, 2002Assignee: Xerox CorporationInventors: Barkev Keoshkerian, Paula J. MacLeod, Peter G. Odell, Michael K. Georges
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Patent number: 6365675Abstract: A process for the preparation of a thermoplastic resin, or thermoplastic resins comprising: forming, or providing a miniemulsion comprised of a mixture of an oligomeric compound of the formula R—SFR, wherein R is an oligomeric compound comprised of from about 1 to about 30 monomer units and optionally a covalently bonded free radical initiator compound, —SFR is a covalently bound stable free radical end group, and at least one free radical polymerizable monomer compound, and a surfactant; and heating the miniemulsion wherein there results a latex thermoplastic resin or a latex of thermoplastic resins with a high monomer to polymer conversion of about 85 to about 100 percent and a narrow polydispersity of from about 1.1 to about 2.0.Type: GrantFiled: June 12, 2000Date of Patent: April 2, 2002Assignee: Xerox CorporationInventors: Paula J. MacLeod, Peter G. Odell, Francisco E. Torres, Michael K. Georges
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Publication number: 20020019505Abstract: A process for the preparation of a thermoplastic resin, or thermoplastic resins comprising:Type: ApplicationFiled: October 12, 2001Publication date: February 14, 2002Applicant: Xerox CorporationInventors: Paula J. MacLeod, Peter G. Odell, Francisco E. Torres, Michael K. Georges
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Patent number: 6320007Abstract: A free radical polymerization process for the preparation of a thermoplastic resin or resins includes the in situ formation of a stable free radical agent from a precursor material in a reactor vessel, introducing a free radical initiator and at least one polymerizable monomer compound into the reactor vessel, and heating a mixture of the free radical initiator, the stable free radical agent, and the polymerizable monomer compound(s) in the reactor vessel to form a thermoplastic resin.Type: GrantFiled: November 18, 1994Date of Patent: November 20, 2001Assignee: Xerox CorporationInventors: Peter M. Kazmaier, Michael K. Georges, Richard P. N. Veregin, Barkev Keoshkerian, Gordon K. Hamer, Karen A. Moffat, Marko Saban
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Patent number: 6258911Abstract: A polymer having groups located at the ends of the polymer chain which groups are derived from stable free radical compounds, wherein the polymer is of the formula: SFR—(R)—SFR wherein SFR represents a covalently bonded stable free radical group and R represents a thermoplastic resin.Type: GrantFiled: August 18, 1994Date of Patent: July 10, 2001Assignee: Xerox CorporationInventors: Michael K. Georges, Toyofumi Inoue, Gordon K. Hamer, Peter M. Kazmaier, Richard P. N. Veregin
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Patent number: 6156858Abstract: A process for the preparation of polymer comprising heating a mixture comprised of a free radical initiator, a stable free radical agent, a base selected from the group consisting of inorganic bases and organic bases, and at least one polymerizable monomer compound and optionally cooling, followed by optionally isolating the polymer product.Type: GrantFiled: June 25, 1997Date of Patent: December 5, 2000Assignee: Xerox CorporationInventors: Barkev Keoshkerian, Michael K. Georges, Peter M. Kazmaier
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Patent number: 6121397Abstract: A process for the preparation of a thermoplastic resin, or thermoplastic resins comprising:forming, or providing a miniemulsion comprised of a mixture of an oligomeric compound of the formula R-SFR, wherein R is an oligomeric compound comprised of from about 1 to about 30 monomer units and optionally a covalently bonded free radical initiator compound, -SFR is a covalently bound stable free radical end group, and at least one free radical polymerizable monomer compound, and a surfactant; andheating the miniemulsion wherein there results a latex thermoplastic resin or a latex of thermoplastic resins with a high monomer to polymer conversion of about 85 to about 100 percent and a narrow polydispersity of from about 1.1 to about 2.0.Type: GrantFiled: July 14, 1997Date of Patent: September 19, 2000Assignee: Xerox CorporationInventors: Paula J. MacLeod, Peter G. Odell, Francisco E. Torres, Michael K. Georges
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Patent number: 6114499Abstract: A process for the preparation of branched thermoplastic resins comprising: heating a mixture of an unsaturated resin, a free radical initiator, and a stable free radical agent; adding to the heated mixture at least on polymerizable monomer; and cooling the mixture, wherein the resulting product is a branched thermoplastic resin with arms or branches comprised of polymerized monomer with substantially uniform length and narrow polydispersity.Type: GrantFiled: April 21, 1999Date of Patent: September 5, 2000Assignee: Xerox CorporationInventors: Peter M. Kazmaier, Karen A. Moffat, Marko D. Saban, Richard P. N. Veregin, Michael K. Georges, Gordon K. Hamer, Toyofumi Inoue, Stephan V. Drappel
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Patent number: 6087451Abstract: A polymer having groups located at the ends of the polymer chain which groups are derived from stable free radical compounds, wherein the polymer is of the formula:SFR-(R)-SFRwherein SFR represents a covalently bonded stable free radical group and R represents a thermoplastic resin.Type: GrantFiled: May 1, 1998Date of Patent: July 11, 2000Assignee: Xerox CorporationInventors: Michael K. Georges, Toyofumi Inoue, Gordon K. Hamer, Peter M. Kazmaier, Richard P. N. Veregin
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Patent number: 6075105Abstract: A process for the preparation of resin particles comprising: heating a mixture comprised of a free radical initiator compound, at least one stable free radical compound, at least one free radical polymerizable monomer compound, and at least one free radical polymerizable crosslinking compound; and cooling the mixture, wherein the resulting product resin particles are crosslinked and are comprised of polymerized monomers and at least one crosslinking compound, and wherein the particles have a narrow particle size distribution, a narrow pore size distribution, and a high monomer to polymer conversion.Type: GrantFiled: August 26, 1996Date of Patent: June 13, 2000Assignee: Xerox CorporationInventors: Barkev Keoshkerian, Michael K. Georges, Peter M. Kazmaier, Gordon K. Hamer
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Patent number: 5932630Abstract: A hot melt ink composition comprised of a triblock copolymer vehicle, and a dye or pigment.Type: GrantFiled: May 2, 1996Date of Patent: August 3, 1999Assignee: Xerox CorporationInventors: Gregory J. Kovacs, Michael K. Georges, Fatima M. Pontes, Stephan V. Drappel
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Patent number: 5919861Abstract: A process for the preparation of branched thermoplastic resins comprising: heating a mixture of an unsaturated resin, a free radical initiator, and a stable free radical agent; adding to the heated mixture at least on polymerizable monomer; and cooling the mixture, wherein the resulting product is a branched thermoplastic resin with arms or branches comprised of polymerized monomer with substantially uniform length and narrow polydispersity.Type: GrantFiled: July 16, 1997Date of Patent: July 6, 1999Assignee: Xerox CorporationInventors: Peter M. Kazmaier, Karen A. Moffat, Marko D. Saban, Richard P. N. Veregin, Michael K. Georges, Gordon K. Hamer
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Patent number: 5891971Abstract: A process for the preparation of a resin comprising:heating a mixture of at least one free radical polymerizable monomer, a free radical initiator compound, a stable free radical compound, and a reducing agent.Type: GrantFiled: August 15, 1997Date of Patent: April 6, 1999Assignee: Xerox CorporationInventors: Barkev Keoshkerian, Marion H. Quinlan, Michael K. Georges, H. Bruce Goodbrand
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Patent number: 5852140Abstract: Disclosed is a process for the preparation of a polymer which comprises effecting bulk polymerization of a mixture of at least one monomer, a free radical polymerization initiator, and a stable free radical agent until from about 10 to about 50 weight percent of the monomer has been polymerized; optionally adding additional free radical initiator; optionally adding a colorant; dispersing with a high shear mixer the aforementioned partially polymerized mixture in water containing a stabilizing component selected from the group consisting of non-ionic and ionic water soluble polymeric stabilizers to obtain a suspension of particles with an average diameter of from about 0.1 to about 10 microns; polymerizing the resulting suspension to form said polymer.Type: GrantFiled: March 25, 1993Date of Patent: December 22, 1998Assignee: Xerox CorporationInventors: Michael K. Georges, Raj D. Patel