Patents by Inventor Michael K. Stern
Michael K. Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7883715Abstract: Solid and liquid pesticidal concentrate and spray compositions are described which exhibit enhanced efficacy due to the addition thereto of a compound which increases EPSPS enzyme inhibition by the pesticide, cell membrane permeability, or expression of hydroxyproline-rich glycoproteins.Type: GrantFiled: August 29, 2003Date of Patent: February 8, 2011Assignee: Monsanto Technology LLCInventors: William Abraham, Michael K. Stern, Jeffrey Alan Graham, Xiaodong Chris Xu, Ronald J. Brinker, Jeffrey N. Travers, Tracey L. Reynolds
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Patent number: 7687434Abstract: A method of improving the yield and vigor of agronomic plants, in particular leguminous plants such as soybeans, involves treating such plants and/or the propagation material of plants with a composition that includes an active agent, such as a fungicide, that has no significant activity against fungal plant pathogens of the treated plant. When the plant is not wheat, a preferred agent of this type is 4,5-dimethyl-N-(2-propenyl)-2-(trimethylsilyl)-3-thiophenecarboxamide (silthiofam). Plants and plant propagation material, such as seeds, that have been treated by the novel method are also described.Type: GrantFiled: December 19, 2001Date of Patent: March 30, 2010Assignee: Monsanto Technology, LLCInventors: Maurice R. De Billot, Schalk Van Wyk, Theunis E. M. Odendaal, Dennis Paul Phillion, Jeffrey S. Coultas, Ernest F. Sanders, Greg A. Penner, Jawed Asrar, Michael K. Stern
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Patent number: 6759549Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.Type: GrantFiled: April 7, 2003Date of Patent: July 6, 2004Assignee: Monsanto Technology LLCInventors: Michael K. Stern, Todd J. Johnson
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Publication number: 20040097372Abstract: Solid and liquid pesticidal concentrate and spray compositions are described which exhibit enhanced efficacy due to the addition thereto of a compound which increases EPSPS enzyme inhibition by the pesticide, cell membrane permeability, or expression of hydroxyproline-rich glycoproteins.Type: ApplicationFiled: August 29, 2003Publication date: May 20, 2004Applicant: Monsanto Technology LLCInventors: William Abraham, Michael K. Stern, Jeffrey Alan Graham, Xiaodong Chris Xu, Ronald J. Brinker, Jeffrey N. Travers, Tracey L. Reynolds
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Publication number: 20030225298Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.Type: ApplicationFiled: April 7, 2003Publication date: December 4, 2003Applicant: Monsanto Technology LLCInventors: Michael K. Stern, Todd J. Johnson
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Publication number: 20030114308Abstract: A method of improving the yield and vigor of agronomic plants, in particular leguminous plants such as soybeans, involves treating such plants and/or the propagation material of plants with a composition that includes an active agent, such as a fungicide, that has no significant activity against fungal plant pathogens of the treated plant. When the plant is not wheat, a preferred agent of this type is 4,5-dimethyl-N-(2-propenyl)-2-(trimethylsilyl)-3-thiophenecarboxamide (silthiofam). Plants and plant propagation material, such as seeds, that have been treated by the novel method are also described.Type: ApplicationFiled: December 19, 2001Publication date: June 19, 2003Applicant: Monsanto Technology, L.L.C.Inventors: Maurice R. De Billot, Schalk Van Wyk, Theunis E.M. Odendaal, Dennis Paul Phillion, Jeffrey S. Coultas, Ernest F. Sanders, Greg A. Penner, Jawed Asrar, Michael K. Stern
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Publication number: 20030088122Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.Type: ApplicationFiled: May 20, 2002Publication date: May 8, 2003Inventors: Todd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
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Publication number: 20020002281Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.Type: ApplicationFiled: June 1, 2001Publication date: January 3, 2002Inventors: Todd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
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Patent number: 6278017Abstract: A process for the continuous production of N-(phosphonomethyl)glycine is provided. In the process, N-(acetyl)iminodiacetic acid is formed in an amidocarboxymethylation reactor system. The N-(acetyl)iminodiacetic acid product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. In either case, the N-(phosphonomethyl)iminodiacetic acid product is recovered and converted to N-(phosphonomethyl)glycine.Type: GrantFiled: July 10, 2000Date of Patent: August 21, 2001Assignee: Monsanto CompanyInventors: Michael K. Stern, Todd J. Johnson, Amy L. Jorgenson, Michael D. Rogers, Thaddeus S. Franczyk, II
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Patent number: 6265605Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.Type: GrantFiled: February 7, 2000Date of Patent: July 24, 2001Assignee: Monsanto CompanyInventors: Todd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
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Patent number: 6258941Abstract: The selected sequence-directed hydrolysis of RNA under physiologically relevant conditions is described using conjugates comprising metal complexes covalently linked to oligodeoxynucleotides as hydrolysis agents. The oligodeoxynucleotide portions of the agents are selected to provide molecular recognition via the Watson Crick base pairing to the target RNA sequence to be hydrolyzed. A method is described for determining the RNA hydrolysis effectiveness of metals and ligands used to form the metal complexes useful in this invention.Type: GrantFiled: September 16, 1992Date of Patent: July 10, 2001Assignee: Washington UniversityInventors: James K. Bashkin, Michael K. Stern, Anil S. Modak
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Patent number: 6245758Abstract: The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe, Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite ed at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite .Type: GrantFiled: September 9, 1996Date of Patent: June 12, 2001Inventors: Michael K. Stern, Daniela Salvemini
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Patent number: 6187937Abstract: A hydroxydiphenylamine compound can be converted to an N-phenylquinoneimine by reacting the hydroxydiphenylamine with oxygen or an oxygen containing gas in the presence of a modified activated carbon catalyst, the catalyst having had surface oxides removed therefrom.Type: GrantFiled: December 23, 1998Date of Patent: February 13, 2001Assignee: Flexsys America L.P.Inventors: Donald L. Fields, Jr., Michael K. Stern, Jayant Shivji Lodaya
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Patent number: 6153753Abstract: Process for the preparation of an N-acyl amino carboxylic acid by means of a carboxymethylation reaction. In this reaction, a reaction mixture is formed which contains a base pair, carbon monoxide, hydrogen and an aldehyde with the base pair comprising a carbamoyl compound and a carboxymethylation catalyst precursor. In a preferred embodiment, the carbamoyl compound and aldehyde are selected to yield an N-acyl amino carboxylic acid which is readily converted to N-(phosphonomethyl)glycine, or a salt or ester thereof.Type: GrantFiled: February 12, 1998Date of Patent: November 28, 2000Assignee: Monsanto CompanyInventors: Todd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
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Patent number: 6130351Abstract: A process for the production of N-(phosphonomethyl)iminodiacetic acid. N-(acetyl)iminodiacetic acid is formed in a amidocarboxymethylation reactor system, into which a source of each of the following is continuously fed: (1) acetamide or an acetamide derivative, (2) formaldehyde or a formaldehyde generator or derivative, (3) a carbonylation catalyst, (4) carbon monoxide, and optionally (5) hydrogen. In turn, an amidocarboxymethylation reaction product stream, which contains N-(acetyl)iminodiacetic acid and the carbonylation catalyst, is withdrawn from the amidocarboxymethylation reactor system. The carbonylation catalyst is separated from the amidocarboxymethylation reaction product stream to recover the carbonylation catalyst and form a catalyst depleted product stream which contains N-(acetyl)iminodiacetic acid.Type: GrantFiled: August 12, 1999Date of Patent: October 10, 2000Assignee: Monsanto CompanyInventors: Michael K. Stern, Todd J. Johnson, Amy L. Jorgenson, Michael D. Rogers, Thaddeus S. Franczyk, II
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Patent number: 5703273Abstract: A process for preparing N-hydroxyalkylaminomethyl-phosphonic acid or salts thereof which comprises contacting an alkanolamine, formaldehyde and a trialkyl phosphite under suitable reaction conditions to produce a reaction mixture, and hydrolyzing the reaction mixture under neutral, acidic or basic conditions. In one embodiment, the N-hydroxyalkylaminomethylphosphonic acid or salts thereof is catalytically oxidized to produce an N-phosphonomethylaminocarboxylic acid or salts thereof.Type: GrantFiled: July 1, 1996Date of Patent: December 30, 1997Assignee: Monsanto CompanyInventors: Michael K. Stern, Brian K. Cheng, Jerry R. Ebner, Dennis P. Riley
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Patent number: 5633407Abstract: A process for preparing substituted aromatic azo compounds is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the azo containing compound in the presence of a suitable base and a controlled amount of protic material at a temperature of about 10.degree. C. to about 150.degree. C. in a confined reaction zone wherein the molar ratio of protic material to base is 0:1 to about 5:1. In another embodiment, the substituted aromatic azo compounds are further reacted with a nucleophilic compound in the presence of a suitable solvent system, a suitable base and a controlled amount of protic material at a temperature of about 70.degree. C. to about 200.degree. C. in a confined reaction zone wherein the molar ratio of protic material to base is 0:1 to about 5:1 to produce a substituted aromatic amine.Type: GrantFiled: May 18, 1995Date of Patent: May 27, 1997Assignee: Flexsys America L. P.Inventors: Michael K. Stern, Brian K-M Cheng
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Patent number: 5623088Abstract: A method of producing 4-ADPA is disclosed wherein aniline or substituted aniline derivatives and nitrobenzene are reacted under suitable conditions to produce 4-nitrodiphenylamine or substituted derivatives thereof and/or 4-nitrosodiphenylamine or substituted derivatives thereof and/or their salts, either or both of which are subsequently reduced to produce 4-ADPA or substituted derivatives thereof. The 4-ADPA or substituted derivatives thereof can be reductively alkylated to produce p-phenylenediamine products or substituted derivatives thereof which are useful as antiozonants.Type: GrantFiled: May 10, 1995Date of Patent: April 22, 1997Assignee: Flexsys America L. P.Inventors: Michael K. Stern, James K. Bashkin
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Patent number: 5618979Abstract: A process for preparing substituted aromatic amines which comprises contacting a nucleophilic compound and a substituted aromatic azo compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the substituted aromatic azo compound in the presence of a suitable base and a controlled amount of protic material at a temperature of about 70.degree. C. to about 200.degree. C. in a confined reaction zone wherein the molar ratio of protic material to base is 0:1 to about 5:1. In another embodiment, the substituted aromatic amines of the invention are reductively alkylated to produce alkylated diamines or substituted derivatives thereof.Type: GrantFiled: May 18, 1995Date of Patent: April 8, 1997Assignee: Flexsys America L. P.Inventors: Michael K. Stern, Brian K-M Cheng
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Patent number: 5608111Abstract: A method of producing 4-ADPA is disclosed wherein aniline or substituted aniline derivatives and nitrobenzene are reacted under suitable conditions to produce 4-nitrodiphenylamine or substituted derivatives thereof and/or 4-nitrosodiphenylamine or substituted derivatives thereof and/or their salts, either or both of which are subsequently reduced to produce 4-ADPA or substituted derivatives thereof. The 4-ADPA or substituted derivatives thereof can be reductively alkylated to produce p-phenylenediamine products or substituted derivatives thereof which are useful as antiozonants.Type: GrantFiled: May 5, 1995Date of Patent: March 4, 1997Assignee: Flexsys America L. P.Inventors: Michael K. Stern, James M. Allman, James K. Bashkin, Roger K. Rains