Patents by Inventor Michael K. Wismer

Michael K. Wismer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO PHARMACOKINETIC-PHARMACODYNAMIC DEVICE
    Publication number: 20180291325
    Abstract: The present invention provides an in vitro cell culturing bioreactor device capable of supporting the growth of adherent or non-adherent mammalian cells. The invention also provides methods for monitoring and/or measuring the effects of therapeutic agents on cells, for determining the pharmacokinetic-pharmacodynamic relationship between a drug and a target cell, and for determining an effective dosing regimen for a drug or therapeutic agent.
    Type: Application
    Filed: May 9, 2016
    Publication date: October 11, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Donna M. Carr, Michael K. Wismer, Charles G. Garlisi
  • Method and apparatus for measuring the volume of an animal paw
    Patent number: 7735366
    Abstract: Disclosed is an improved method for measuring the volume of an animal paw, suitable for use in a rat paw edema assay. Also disclosed is a novel apparatus for measuring the volume of liquid displaced by the insertion of an object into a liquid filled cup (1) which is on a cup holder basin (3), the liquid filled cup and cup holder basin being inside a rectangular support assembly (5), the measurement obtained by determining the buoyant force produced as a result of the displacement of the liquid by the animal paw.
    Type: Grant
    Filed: May 6, 2006
    Date of Patent: June 15, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Gary S. Kath, Michael K. Wismer, Paul R. Augustine, Cordelia G. Rasa
  • METHOD AND APPARATUS FOR MEASURING THE VOLUME OF AN ANIMAL PAW
    Publication number: 20090282913
    Abstract: Disclosed is an improved method for measuring the volume of an animal paw, suitable for use in a rat paw edema assay. Also disclosed is a novel apparatus for measuring the volume of liquid displaced by the insertion of an object into a liquid filled cup (1) which is on a cup holder basin (3), the liquid filled cup and cup holder basin being inside a rectangular support assembly (5), the measurement obtained by determining the buoyant force produced as a result of the displacement of the liquid by the animal paw.
    Type: Application
    Filed: May 5, 2006
    Publication date: November 19, 2009
    Inventors: Gary S. Kath, Michael K. Wismer, Paul R. Augustine, Cordelia G. Rasa