Abstract: A method for providing localized treatment at a target site in the brain of a patient is provided. The method comprises providing a system comprising a miniature device configured to carry one or more therapeutic components for performing the treatment, and an external system configured to direct the miniature device; inserting the miniature device to a starting location within the patient; operating the external system to direct the miniature device to travel along an access path from the starting location to the target site; and administering the therapeutic component at the target site. A system for performing the method is further provided.

Abstract: An apparatus and methods of use thereof, the apparatus comprising: a medical device, configured to reside and to be manipulated within a first lumen; and a driving system, configured to manipulate—and/or control—the medical device, via a second lumen. The driving system comprising: a catheter, configured to be inserted into—and to navigate—or to be navigated—within the second lumen; and a driver, configured to travel within the catheter, and to remotely manipulate—and/or control—the medical device residing in the first lumen.

Abstract: A system for facilitating performing a therapeutic activity at a predetermined treatment site in a patient is provided. The system comprises an elongated miniature device extending along a longitudinal axis spanning between a distal cutting end formed with a sharp cutting portion, and a blunt proximal abutting end. The elongated body comprises a substantially non-convex bottom surface extending substantially between the cutting end and the abutting end. The system further comprises a driving device configured to generate a varying magnetic field to remotely control motion of the miniature device.

Abstract: A method for providing localized treatment at a target site in the brain of a patient is provided. The method comprises providing a system comprising a miniature device configured to carry one or more therapeutic components for performing the treatment, and an external system configured to direct the miniature device; inserting the miniature device to a starting location within the patient; operating the external system to direct the miniature device to travel along an access path from the starting location to the target site; and administering the therapeutic component at the target site. A system for performing the method is further provided.

Abstract: A method and apparatus for safely and reliably accessing a subarachnoid space (SAS) or other target area of a patient is provided in which a tube having at least one lumen with a tissue puncture device therein is inserted into the patient near the tissue. The lumen has a suction port at one end adapted to suction the dura/arachnoid tissue away from the pia mater so that the tissue can be punctured to access the SAS space. The movement of the needle in the lumen is controlled by controlling a magnetic field. Tissue puncture devices for use alone or in connection with the apparatus are also provided.

Abstract: This invention relates to coated mesoporous nanoparticles (MSN). The coating material is an ultrasound-responsive material (for example a polymer) and it acts as a control layer for blocking/release of material loaded in the pores of the MSN.

Abstract: Apparatus and methods for imaging and tracking of nano- and micro-scale objects with acceptable latency for relevant medical procedures, such as delivery of therapeutic payload or minimally invasive surgery are disclosed, including the capability to superimpose accurate anatomical data over a tracking image. Software applications are provided for data logging via a remote-control station; and software interface with remote motion control mechanism, controlling the motion of internal device.

Abstract: A device for damaging a parasite while being on a surface of a body of a mammal. The device is a hand held device with an ultrasound transmitter for generating ultrasound radiation and a plurality of teeth extending from a base of the device and arranged alternately.

Abstract: A method is provided for accessing a pericardial space of a subject. The method includes advancing a guide member toward a heart, having (a) a transparent blunt distal end, and (b) a side-facing suction port. During advancing of the guide member, an imaging device disposed in the guide member generates an image of part of the heart. Subsequently to contacting the pericardium with the suction port, the imaging device is retracted proximally in the guide member. Subsequently, a portion of the pericardium is drawn into the guide member through the suction port. Following the drawing of the portion into the guide member, an image of the pericardium disposed within the suction port, is generated. Subsequently, a puncturing element is advanced in the guide member to puncture the portion of the pericardium that is in the guide member. Other applications are also described.

Abstract: Apparatus comprising an ultrasound ablation system, which comprises a reflection-facilitation element, configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool, which comprises at least one ultrasound transducer configured to be positioned within a heart chamber of the subject. The ultrasound transducer is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

Abstract: Apparatus comprising a reflection-facilitation element, which is disposed in the pericardial cavity of a subject and on a first side of a tissue of the subject. The reflection-facilitation element comprises an inflatable member, having a first side and a second side, and configured to be inflated while disposed in the pericardial cavity, and a plurality of electrodes, comprising at least a first electrode and a second electrode, the first electrode being disposed on the first side of the inflatable member. The apparatus further comprises an ultrasound transducer placed on a second side of the tissue of the subject, and configured to apply ultrasound energy to the tissue of the subject such that at least a portion of the energy reaches the inflatable member. The inflatable member reflects at least a portion of the ultrasound energy that reaches the inflatable member.

Abstract: Apparatus (610) for closure of a left atrial appendage (220) of a heart, comprising a deployment device (520) configured to enter a pericardial region of the heart and to be advanced toward an outer surface of the left atrial appendage; and first and second rigid longitudinal rod elements (630) coupled to each other by at least one coupling suture (552), the first and second rigid longitudinal rod elements (630) being deployable by the deployment device on opposing external surfaces of the left atrial appendage, and configured to compress tissue of the left atrial appendage due to pulling of at least one proximal portion of the coupling suture (552). Other applications are also described.

Abstract: A method is provided for accessing a pericardial space of a subject. The method includes advancing a guide member toward a heart, having (a) a transparent blunt distal end, and (b) a side-facing suction port. During advancing of the guide member, an imaging device disposed in the guide member generates an image of part of the heart. Subsequently to contacting the pericardium with the suction port, the imaging device is retracted proximally in the guide member. Subsequently, a portion of the pericardium is drawn into the guide member through the suction port. Following the drawing of the portion into the guide member, an image of the pericardium disposed within the suction port, is generated. Subsequently, a puncturing element is advanced in the guide member to puncture the portion of the pericardium that is in the guide member. Other applications are also described.

Abstract: Apparatus comprising an ultrasound ablation system, which comprises a reflection-facilitation element, configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool, which comprises at least one ultrasound transducer configured to be positioned within a heart chamber of the subject. The ultrasound transducer is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

Abstract: Apparatus comprising an ultrasound ablation system (10), which comprises a reflection-facilitation element (12), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultra-sound tool (20), which comprises at least one ultrasound transducer (40) configured to be positioned within a heart chamber of the subject. The ultrasound transducer (40) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

Abstract: Apparatus comprising a reflection-facilitation element, which is disposed in the pericardial cavity of a subject and on a first side of a tissue of the subject. The reflection-facilitation element comprises an inflatable member, having a first side and a second side, and configured to be inflated while disposed in the pericardial cavity, and a plurality of electrodes, comprising at least a first electrode and a second electrode, the first electrode being disposed on the first side of the inflatable member. The apparatus further comprises an ultrasound transducer placed on a second side of the tissue of the subject, and configured to apply ultrasound energy to the tissue of the subject such that at least a portion of the energy reaches the inflatable member. The inflatable member reflects at least a portion of the ultrasound energy that reaches the inflatable member.

Abstract: Apparatus (120) is provided comprising: a longitudinal guide member (220) (a) comprising a blunt distal end (160) having an outer surface (164) at least part of which is transparent, (b) configured to be advanced distally toward a heart of a subject, and (c) shaped to define an at least partially distally-facing and side-facing suction port (660) at a distal portion (662) of the longitudinal guide member (220). The apparatus is configured to facilitate drawing a portion of a pericardium of the heart through the suction port and into the longitudinal guide member. The apparatus additionally comprises a puncturing element (50) configured to puncture the portion of the pericardium while the portion of the pericardium is in the longitudinal guide member. Other applications are also described.

Abstract: Apparatus and methods are described, including apparatus comprising a longitudinal guide member comprising a blunt distal end having an outer surface at least part of which is transparent. The guide member is advanced distally toward a heart of a subject. A sheath is shaped and sized to surround the guide member and shaped to define an at least partially distally-facing suction port at a distal end of the sheath. A portion of a pericardium of the heart is drawn through the suction port and into the sheath, when the suction port is distal to the guide member. A puncturing element punctures the portion of the pericardium while the portion of the pericardium is in the sheath, and a puncturing-element-restraining element inhibits passage of a distal tip of the puncturing element out of the distal end of the sheath. Other applications are also described.

Abstract: Apparatus for ablating tissue of a subject is provided. The apparatus includes a reflection-facilitation element (20) having an inflatable element (22), which is placed at a first side of the tissue of the subject; and an introducer (24), coupled to the inflatable element which delivers a fluid to the first side of the tissue, such that a portion of the fluid is disposed within the inflatable element, and another portion of the fluid is disposed outside of the inflatable element. The apparatus also includes an ultrasound tool (90), having at least one ultrasound transducer (92), which is placed at a second side of the tissue, and applies ultrasound energy such that at least a portion of the applied energy is reflected by the fluid. Other applications are also described.

Abstract: Apparatus is provided, which includes at least one ultrasound transducer. The ultrasound transducer is configured to be positioned within a lumen of a subject and to ablate tissue surrounding a wall of the lumen without ablating the wall of the lumen, by focusing ultrasound energy on a focal zone that is outside of the wall of the lumen. A transluminal delivery tool is configured to position the ultrasound transducer in the lumen, and a control unit is configured to drive the ultrasound transducer. Other embodiments are also described.