Abstract: The disclosure teaches antibodies that are useful, inter alia, in methods for detecting and treating human cancer. In a particular aspect, the disclosure teaches novel antibodies that are useful for detecting and treating human breast cancer. In some embodiments, the disclosure teaches novel antibodies that bind to filamin A. In some embodiments, the antibodies are intrabodies.

Abstract: A valve mechanism system in a hydraulic rocker arm for a combustion engine includes a check valve spring, a check valve ball and a control piston. The spring contacting the ball are arranged in a seat in a recess in the arm. The recess has a first opening to a rocker arm channel connected to a hydraulic element and a second opening to a rocker arm oil supply via a second channel. The piston has a first end with a pin axially aligned with the piston arranged in contact with the ball on the opposite side of the ball from the spring. The ball is movable between a first position allowing oil to flow to and from the oil supply and a second position stopping oil from flowing between the two channels. A control piston spring is arranged on a second end of the piston such that it biases the piston towards the ball.

Abstract: A valve mechanism system in a hydraulic rocker arm (1) for a combustion engine comprises a check valve spring (2) and a check valve ball (3). Said spring (2) is arranged to be in contact with the check valve ball (3) and said spring (2) and ball (3) are arranged in a seat (4) in a recess (5) in the rocker arm (1). The recess (5) has a first opening (6) to a rocker arm channel (7) connected to a hydraulic element and a second opening (8) to a rocker arm oil supply via a second channel (9). The system further comprises a control piston (10) having a first end with a pin (11) axially aligned with the control piston (10) arranged in contact with said check valve ball (3) on the opposite side of the check valve ball (3) from the check valve spring (2). The check valve ball (3) is movable between a first position allowing oil to flow to and from the oil supply and a second position stopping oil from flowing between the two channels (7, 9).