Abstract: Techniques regarding autonomous generation of one or more sets of diverse plans are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a planner component, operably coupled to the processor, that can generate a first plan based on a planning task. The computer executable components can also comprise a modification component, operably coupled to the processor, that can generate a modification to the planning task to facilitate generation of a second plan by the planner component. The second plan can be a variant of the first plan.

Abstract: A method for improving performance of at least one hardware processor solving a top-k planning problem includes obtaining, in a memory coupled to the at least one processor, a specification of the planning problem in a planning language; obtaining, in a first iteration carried out by the at least one processor, at least one solution to the planning problem; and modifying the planning problem, in the first iteration carried out by the at least one processor, to forbid the at least one solution. The method further includes repeating, by the at least one processor, the obtaining of the at least one solution and the modifying to forbid the at least one solution, for a plurality of additional iterations, after the first iteration, until a desired number, k, of solutions to the planning problem are found or until no further solutions exist, whichever comes first.

Abstract: A method comprising obtaining a scheduling problem comprising: a set of agents and a set of tasks to be performed by the set of agents, wherein solving the scheduling problem using an automated solver is not feasible using available predetermined resources. The method comprises automatically generating a plurality of alternative scheduling problems, wherein a solution to each such alternative scheduling problem defines a solution to the scheduling problem and determining a solution to the scheduling problem by applying the automated solver to solve, while using the available predetermined resources, an alternative problem of the plurality of alternative scheduling problems to determine a solution to the alternative problem and by mapping the solution to the alternative problem to the scheduling problem, whereby determining the solution.

Abstract: The present application is directed to a method for the conversion of nitrous acid to dinitrogen gas. In particular, the present application relates to a method for the conversion of nitrous acid to dinitrogen gas by contacting the nitrous acid with an amine-functionalized metal organic framework.

Abstract: Techniques facilitating estimating and visualizing entity to agent collaboration to facilitate automated plan generation are provided. In one example, a computer-implemented method comprises generating, by a device operatively coupled to a processor, a plan based on receiving first input data associated with an instance model. The computer-implemented method also comprises generating, by the device, a revised plan based on receiving second input data, associated with a revised instance model, from an entity. Furthermore, the computer-implemented method comprises, tracking, by the device, a contribution of the entity as a function of a modification from the instance model to the revised instance model.

Abstract: A computer program product comprising a non-transitory computer readable storage medium retaining program instructions configured to cause a processor to perform actions, which program instructions implement: a framework for creating a model of an NP-hard problem, the model comprising at least one entity selected from the group comprising: an objective, a variable, an equation and a constraint, wherein the framework provides methods for automatically transforming the model, comprising: one or more methods for manipulating or changing a status of the entity of the model, the methods comprising a method for imposing or ignoring the constraint; and one or more methods related to operations to be applied to the entity of the model.

Abstract: This disclosure features gastro-retentive (GR) modified release pharmaceutical dosage forms (e.g., solid dosage forms, e.g., tablets, e.g., bilayer tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the dosage form.

Abstract: A computer-implemented method, computerized apparatus and computer program product for selecting time windows to vehicle routing problems. A set of criteria for estimating desirability of scheduling an appointment to a time interval, and a set of time intervals at which appointments can be scheduled are obtained. A new appointment for scheduling to a time interval is received. For each time interval of the set, a balanced score according to the set of criteria is calculated. A time interval for scheduling the new appointment is selected based on the balanced score.

Abstract: A method, apparatus and product for real-time update of a Mobile Workforce Scheduling Problem (MWSP), which comprises: agents and tasks to be performed by the agents, wherein a schedule which solves the mobile workforce scheduling problem exists and is being implemented by the agents. The method comprising: monitoring real time information update events provided to a Business Rule Management System (BRMS), activating, by the BRMS, business rules for schedule change detection; in response to a determination that re-planning is desired, automatically determining, using business rules, a portion of the MWSP to be re-planned; providing the portion of the MWSP to a MWSP solver; receiving from the MWSP solver, a new schedule for the portion of the MWSP; and updating the schedule based on the new schedule, whereby a first portion of the schedule is updated and a second portion of the schedule remains unchanged.

Abstract: This disclosure features immediate release pharmaceutical formulations (e.g., solid dosage forms, e.g., tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the formulations.

Abstract: A computer-implemented method, computerized apparatus and computer program product for decomposing multisite heterogeneous workforce scheduling problems. An instance of a multisite heterogeneous workforce scheduling problem comprising a set of work items and a set of technicians is obtained. A measure of likelihood that a pair of work items belong to the same sub-problem in a decomposition of the problem instance into a plurality of sub-problems, such that a union of solutions to the plurality of sub-problems is a solution to the problem, is calculated. The measure calculation comprises calculating one or more components indicating a relation between the pair of work items and technicians potentially scheduled to execute either of them. A solution to the problem is generated by solving the plurality of sub-problems in the decomposition obtained based on a partitioning of the set of work items induced by the measure and aggregating solutions to the plurality of sub-problems.

Abstract: A computer-implemented method, apparatus and computer program product, the method performed by a processor operatively connected to a memory, the method comprising: obtaining a schedule for handling service requests, the schedule planned offline in accordance with expected service requests for a service, the schedule comprising a number of service trips per time slot and per geographic location; receiving a service request, comprising a location in which the service is to be provided; automatically suggesting, during handling the service request, a time slot for providing the service from time slots available in the schedule for providing the service in the location; and upon acceptance of the time slot for providing the service, updating the schedule with the service being provided at the time slot.

Abstract: The present application is directed to a method for the conversion of nitrous acid to dinitrogen gas. In particular, the present application relates to a method for the conversion of nitrous acid to dinitrogen gas by contacting the nitrous acid with an amine-functionalized metal organic framework.

Abstract: A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.

Abstract: A computer program product comprising a non-transitory computer readable storage medium retaining program instructions configured to cause a processor to perform actions, which program instructions implement: a framework for creating a model of an NP-hard problem, the model comprising at least one entity selected from the group comprising: an objective, a variable, an equation and a constraint, wherein the framework provides methods for automatically transforming the model, comprising: one or more methods for manipulating or changing a status of the entity of the model, the methods comprising a method for imposing or ignoring the constraint; and one or more methods related to operations to be applied to the entity of the model.

Abstract: A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4 -hydroxylase enzyme (C4H), the ratio Kcat(PAL)/Kcat(C4H) is at least 2:1.

Abstract: A method comprising obtaining a scheduling problem comprising: a set of agents and a set of tasks to be performed by the set of agents, wherein solving the scheduling problem using an automated solver is not feasible using available predetermined resources. The method comprises automatically generating a plurality of alternative scheduling problems, wherein a solution to each such alternative scheduling problem defines a solution to the scheduling problem and determining a solution to the scheduling problem by applying the automated solver to solve, while using the available predetermined resources, an alternative problem of the plurality of alternative scheduling problems to determine a solution to the alternative problem and by mapping the solution to the alternative problem to the scheduling problem, whereby determining the solution.

Abstract: The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.

Abstract: According to one embodiment, a method for solving a plurality of spatiotemporal planning problems. The method may include creating a domain model. The method may also include assigning a solution bound associated with the created domain model to infinity. The method may further include calculating a solution to the created domain model based on the assigned solution bound using at least one of a best-first search algorithm. The method may also include updating the assigned solution bound based on the calculated solution. The method may further include presenting the calculated solution to a user based on the updated solution bound not equaling infinity.

Abstract: A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.