Abstract: The present invention relates to a compound of formula (I), pharmaceutically acceptable salts thereof as well as pharmaceutical compositions, for use in a method of topical treatment of a skin disease or skin disorder of a mammal, wherein said method comprises topical administration of said compound to said mammal, Formula (I) wherein R1 is selected from carbocyclyl or heterocyclyl, each independently optionally substituted with C1-C4alkyl, halogen, oxo, CF3, OR4, NR5R6, C6H5, C6H5 substituted with halogen, C1-C3alkyl, OR4, NR5R6, wherein R4, R5, R6 are independently at each occurrence H, C1-C3alkyl; R2 is selected from C5-C12alkyl, C4-C10alkoxy, C1-C3 alkylene-cycloalkyl, C1-C3alkylene-aryl, C1-C3alkylene-heteroaryl, wherein said alkyl, cycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more, typically and preferably one or two, substituents selected from C1-C2 alkyl, C1-C2 haloalkyl, halogen, C1-C2 alkoxy; R3 is (Ia), wherein R7, R8, R9 and R10 are independently at eac

Abstract: The invention relates to a novel extract from the resin of a plant of the genus Boswellia (Burseraceae). The invention further relates to a composition comprising the novel extract, in particular a pharmaceutical composition or a cosmetic composition, or a food supplement, a food or a beverage comprising the extract. Further, the invention concerns the use of the extract and the respective compositions, in particular the use of the extract or a composition comprising the extract in the cosmetic or therapeutic field as well as in food supplements. The invention also relates to the novel extract and the respective compositions for use in the treatment and/or prevention of a disease. A method of treatment and/or prevention of a neurodegenerative disease is further provided. A process is also provided, by which the novel extract is obtained.

Abstract: The invention relates to a novel extract from the resin of a plant of the genus Boswellia (Burseraceae). The invention further relates to a composition comprising the novel extract, in particular a pharmaceutical composition or a cosmetic composition, or a food supplement, a food or a beverage comprising the extract. Further, the invention concerns the use of the extract and the respective compositions, in particular the use of the extract or a composition comprising the extract in the cosmetic or therapeutic field as well as in food supplements. The invention also relates to the novel extract and the respective compositions for use in the treatment and/or prevention of a disease. A method of treatment and/or prevention of a neurodegenerative disease is further provided. A process is also provided, by which the novel extract is obtained.

Abstract: A method and an apparatus determine a road condition using a vehicle camera. At least one image is acquired using the camera. A first image area that includes an image of the road surface is determined in the at least one image. A classifier assigns the first image area to at least one class (among pre-established classes) that represents a specific road condition of the road surface. Information regarding this specific road condition is output.

Abstract: This invention relates to a method and apparatus for determining a road condition using a vehicle camera (6), and it includes the following steps: at least one image (I) is taken using the vehicle camera (S10); a first image area (R1) is determined that includes an image of the road surface (1) (S16); said first image area (R1) is fed to a classifier, wherein the classifier assigns at least one class to said first image area that represents a specific road condition (S18); and information is output with respect to this at least one road condition (S20).