Abstract: Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and/or tetra-aqua systems of free ionic metals and ionic salts as the ionophores, useful in transporting pharmaceutical, nutrient, and personal healthcare compounds. Also described are methods of their administration, methods of their synthesis and manufacture, and the ionophore products of such synthesis and manufacturing methods.