Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: A system for self-directed computer system validation includes first logic to provide a graphical user interface to enable a user to select a set of selected requirements from a plurality of available requirements; second logic to select a set of procedures to satisfy the need to test against each of the requirements and document evidence of the outcomes and generate a set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system; and third logic to provide the set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system.

Abstract: A denitrification system for denitrified wastewater or nitrified water treatment using a detergent or detergent-like compound comprising available carbon. The system comprises a plurality of interconnected tanks including a mixing tank which feeds detention tanks which in combination provide a detention time period for the effluent. A controller determines the amount of detergent dispensed into the mixing tank in accordance with the measured volume of effluent to be treated. The mixing tank comprises a heater for maintaining the nitrified effluent temperature above 50 degrees F. An optional line filter can be added to the output of the system for further reducing organic nitrogen concentration. An alternate embodiment comprises passing the final denitrified effluent through a pump chamber for pumping of the effluent to a sand filter capable of reducing bacterial populations.

Abstract: A denitrification system for denitrified wastewater or nitrified water treatment using a detergent or detergent-like compound comprising available carbon. The system comprises a plurality of interconnected tanks including a mixing tank which feeds detention tanks which in combination provide a detention time period for the effluent. A controller determines the amount of detergent dispensed into the mixing tank in accordance with the measured volume of effluent to be treated. The mixing tank comprises a heater for maintaining the nitrified effluent temperature above 50 degrees F. An optional line filter can be added to the output of the system for further reducing organic nitrogen concentration. An alternate embodiment comprises passing the final denitrified effluent through a pump chamber for pumping of the effluent to a sand filter capable of reducing bacterial populations.

Abstract: A denitrification system for denitrified wastewater or nitrified water treatment using a detergent or detergent-like compound comprising available carbon. The system comprises a plurality of interconnected tanks including a mixing tank which feeds detention tanks which in combination provide a detention time period for the effluent. A controller determines the amount of detergent dispensed into the mixing tank in accordance with the measured volume of effluent to be treated. The mixing tank comprises a heater for maintaining the nitrified effluent temperature above 50 degrees F. An optional line filter can be added to the output of the system for further reducing organic nitrogen concentration. An alternate embodiment comprises passing the final denitrified effluent through a pump chamber for pumping of the effluent to a sand filter capable of reducing bacterial populations.

Abstract: In a system for cleaning a workpiece or wafer, a boundary layer of heated liquid is formed on the workpiece surface. Ozone is provided around the workpiece. The ozone diffuses through the boundary layer and chemically reacts with contaminants on the workpiece surface. Preferably, the liquid includes water, and may also include a chemical. Steam may also be used with the steam also physically removing contaminants, and also heating the workpiece to speed up chemical cleaning. Sonic or electromagnetic energy may also be introduced to the workpiece.

Abstract: A denitrification system for denitrified wastewater or nitrified water treatment using a detergent or detergent-like compound comprising available carbon. The system comprises a plurality of interconnected tanks including a mixing tank which feeds detention tanks which in combination provide a detention time period for the effluent. A controller determines the amount of detergent dispensed into the mixing tank in accordance with the measured volume of effluent to be treated. The mixing tank comprises a heater for maintaining the nitrified effluent temperature above 50 degrees F. An optional line filter can be added to the output of the system for further reducing organic nitrogen concentration. An alternate embodiment comprises passing the final denitrified effluent through a pump chamber for pumping of the effluent to a sand filter capable of reducing bacterial populations.

Abstract: In a system for cleaning a workpiece or wafer, a boundary layer of heated liquid is formed on the workpiece surface. Ozone is provided around the workpiece. The ozone diffuses through the boundary layer and chemically reacts with contaminants on the workpiece surface. A jet of high velocity heated liquid is directed against the workpiece, to physically dislodge or remove a contaminant from the workpiece. The jet penetrates through the boundary layer at the point of impact. The boundary layer otherwise remains largely undisturbed. Preferably, the liquid includes water, and may also include a chemical. Steam may also be jetted onto the workpiece, with the steam also physically removing contaminants, and also heating the workpiece to speed up chemical cleaning. The workpiece and the jet of liquid are moved relative to each other, so that substantially all areas of the workpiece surface facing the jet are exposed at least momentarily to the jet.

Abstract: A moulded nylon glass fiber reinforced fixing device has an elongate body with leading and trailing ends, the body comprises two or more similar legs which splay apart to hold the device in position when the leading end is driven into blockwork. Devices shown are rectangular in section with legs defined by slot(s) running partially along the length of the device away from the leading end. One form of device has a slot extending through its thickness defining two legs and another two slots defining four legs. A third has two slots each extending partway through the device from opposed faces and which are parallel and separated by a readily rupturable wall part. A fourth has a slot extending between readily rupturable parts of opposed side walls of the device. Surfaces to contact blockwork may be roughened and surfaces defining slot(s) may have triangular grooves therein.

Abstract: A screen assembly includes at least one panel with slots in its side edges, a plurality of upright poles to which the panel is fastened and a plurality of fastening elements. The fastening elements and the panel are arranged such that a foot portion of a fastening element can be inserted into one of the slots and can then be rotated in the slot about an axis transverse to the slot, whereupon the foot portion becomes progressively more securely clamped in the slot and in a final position is locked to the panel. The fastening element is thus easily fixed to the panel and provides a very secure fixing when so fixed.

Abstract: A method is disclosed for coating rusted matallic surfaces which comprises (a) removing loose rust particles by superficial surface treatment, (b) applying a coating containing about 55-95% by weight of an aliphatic(meth)acrylic monomer having at least two sites of polymerizable unsaturation and having a 25.degree. C. vapor pressure of no greater than about 0.5 mmHg and a 25.degree. C. viscosity in the range of about 3 cps to about 100 cps, about 0.5-5.0% by weight of a peroxide curing system and about 5.0-35.0% by weight of a drying oil-based oxygen scavenger system, and (c) allowing the coating to cure under ambient conditions.