Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.

Abstract: The invention relates to a chimeric antigen receptor (CAR) that binds to mesothelin and cells that express the CAR, as well as uses thereof for the treatment of cancer.

Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.

Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.

Abstract: A retainer comprises at least two retaining straps or retainer screws and a retainer plate having a cord hole, a slot, and a plurality of retainer holes or retainer strap notches. The retainer maintains connection of an electrical power plug at an end of an electrical power cord to an electrical power receptacle when the retainer is installed. The cord hole and slot extend through the retainer plate, and the slot extends from an edge of the retainer plate to the cord hole. Each of the at least two retaining straps is operable to engage a retainer hole or retaining strap notch in the retainer plate and extend from the retainer plate around the electrical power receptacle and back to the retainer plate.