Abstract: A method for the control of a controllable aggregate, in particular a transmission of a motor vehicle, in which to form at least one determinant magnitude various or varying numbers of contributions from delivery objects are taken into account, at least two different delivery objects being provided, by way of which respective contributions for the determination of the determinant magnitude are determined and such that a counter is provided, to which the contributions by all the delivery objects are sent. The counter evaluates each contribution by way of a weighting and sends it to an evaluating mechanism and this evaluating mechanism determines the determinant magnitude from the evaluated contributions. In addition, the invention concerns a control unit for the control of a controllable aggregate in accordance with such a method and an aggregate with such a control unit.

Abstract: The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in the prognosis of clinical outcome and/or prediction of drug response of such cancers.

Abstract: The present invention provides polynucleotides which regulate the expression of a gene involved in apoptosis. Also provided are methods for identifying agents that modulate expression of a gene involved in apoptosis.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: The invention concerns genes and gene sets and methods useful in the prediction of the response of a cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor.

Abstract: The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences and methods of use thereof are also provided.

Abstract: The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: A method is described for operating an automatic transmission in which a command for changing a current ratio of the automatic transmission is generated when achieving preset operating states of the vehicle automatically or by manual input in a manual shifting mode, the activated manual shifting mode being preferred to an automatic shifting mode. The manual shifting mode is quit when a current vehicle speed is less than a threshold value, or when a longitudinal acceleration of the vehicle is within a defined range, a lateral acceleration is less than a threshold value and a driver type evaluation counter is less than a limiting value.

Abstract: A shift device for an automatic transmission of a vehicle, particularly of a motor vehicle, is proposed in which the request to change the current ratio of the automatic transmission upon reaching preset operating states of the vehicle can be automatically generated or by manual input in a manual shifting mode. A pulse counter is here provided by way of successive pulses and manual input can be functionally interlinked wherein a shift signal can be generated depending on the linkage.

Abstract: A method and cell line for screening test compounds for antiinflammatory activity are disclosed. The cell line is a human cell line capable of producing a selected cytokine associated with an inflammatory response in humans, and transfected with (i) a vector containing DNA encoding a cytokine regulatory factor under the control of a first promoter, and (ii) a vector containing DNA encoding a detectable-marker protein, under the control of a second promoter which is responsive to cytokine induction. In the screening method, the cells are cultured under conditions of cytokine regulatory factor overexpression and cytokine induction. Addition of test compound that results in a diminution of the detectable-marker protein is evidence of anti-inflammatory activity.

Abstract: The invention relates to methods of using fragmented RNA, such as RNA obtained from archived fixed paraffin-embedded tissue material (FPET RNA) or other clinically biopsied tissue specimens for universal gene expression profiling.

Abstract: The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences and methods of use thereof are also provided.

Abstract: A purified insulin-like growth factor binding protein (IGFBP) selected from the group consisting of insulin-like growth factor binding protein having an amino acid sequence that, preferably, is at least 70% homologous to the amino acid sequence of FIG. 1 and fragments thereof that are capable of binding to an antibody specific for the protein or to an insulin-like growth factor is described. This new IGFBP is designated herein as IGFBP-6. Recombinant DNA molecules encoding the binding proteins and subsequences thereof are also described along with recombinant microorganisms and cell lines containing the DNA molecules and methods for producing the binding proteins using recombinant hosts containing the relevant DNA molecules. Antibodies to the protein, useful in various diagnostic applications, are also described.

Abstract: The invention concerns an integrated, qRT-PCR-based system for analyzing and reporting RNA expression profiles of biological samples. In particular, the invention concerns a fully optimized and integrated multiplex, multi-analyte method for expression profiling of RNA in biological samples, including fixed, paraffin-embedded tissue samples. The gene expression profiles obtained can be used for the clinical diagnosis, classification and prognosis of various pathological conditions, including cancer.

Abstract: A method for controlling an automatic transmission of a motor vehicle in the event of a spontaneous gas/pedal release (FastOff). The automatic transmission is driven by an internal combustion engine which can be influenced by an accelerator pedal and a signal proportional to a pedal position is fed to an electronic transmission control in which shifting characteristic field is stored and the spontaneous gas/pedal release (FastOff) is detected and an upshift block (FFO=1) is activated when a pedal position gradient (PSTG) falls below a pedal gradient threshold (KF_PSTG). The mode of the upshift block (FFO=1) is removed when a traction operation is detected when an actual engine torque (MMM) exceeds a push-pull line (KL_ZS) stored as a function of a value equivalent to an engine rotational speed (NMO) in dependence on a vehicle acceleration/deceleration (AIST) dependent on an overall tractional resistance (GFW) and pedal gradient thresholds (KW_PSTGPOS, KW_PSTGNEG).