Patents by Inventor Michael Kiffe

Michael Kiffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC ANTIBODIES FOR USE IN TREATMENT OF HIDRADENITIS SUPPURATIVA
    Publication number: 20240294626
    Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof for use in the treatment or for use in alleviating the symptoms of hidradenitis suppurativa in a subject.
    Type: Application
    Filed: June 20, 2022
    Publication date: September 5, 2024
    Inventors: Sabine BECK, Michael KIFFE, Jiri KOVARIK, Christian LOESCHE, Margarida RODRIGUES, Richard STEIN, Yu TANG, Frank WALDRON-LYNCH
  • MULTISPECIFIC ANTIBODIES TARGETING IL-13 AND IL-18
    Publication number: 20230357381
    Abstract: Described herein are multispecific antibodies targeting IL-13 and IL-18. The multispecific antibodies can be antagonistic and/or therapeutic antibodies targeting IL-13 and IL-18. Also described herein are methods of making said multispecific antibodies, methods of inhibiting IL-13 and IL-18 simultaneously with said multispecific antibodies, and methods of treating an IL-13/IL-18 mediated disorder, such as atopic dermatitis, by administering a multispecific antibody described herein.
    Type: Application
    Filed: April 25, 2023
    Publication date: November 9, 2023
    Inventors: Michael Otto BARDROFF, Regis CEBE, Jiri KOVARIK, Frank KOLBINGER, Michael KIFFE, Anett RITTER, Lukas ROTH
  • Bispecific Antibodies for use in treatment of NLRC4-GOF inflammasomapathy
    Publication number: 20220177569
    Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof for use in the treatment or for use in alleviating the symptoms of an NLRC4 inflammasomopathy, such as an NLRC4-GOF inflammasomopathy in a subject in need thereof. This invention also relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof for use in the treatment or for use in alleviating the symptoms of AIFEC in a subject in need thereof.
    Type: Application
    Filed: November 16, 2021
    Publication date: June 9, 2022
    Inventors: Guido JUNGE, Michael KIFFE, Jiri KOVARIK, Richard STEIN, Frank WALDRON-LYNCH
  • Epothilons C and D, preparation and compositions
    Patent number: 6831076
    Abstract: The present invention relates to epothilon derivatives and to their use.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: December 14, 2004
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Gerhard Hoefle, Michael Kiffe
  • Epothilons C and D, preparation and compositions
    Publication number: 20040087634
    Abstract: The present invention relates to epothilon derivatives and to their use.
    Type: Application
    Filed: June 25, 2003
    Publication date: May 6, 2004
    Inventors: Gerhard Hoefle, Michael Kiffe
  • Epothilons C and D, preparation and compositions
    Patent number: 6613912
    Abstract: The present invention relates to epothilon derivatives and to their use.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: September 2, 2003
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Gerhard Hoefle, Michael Kiffe
  • Epothilons C and D, preparation and compositions
    Publication number: 20010034452
    Abstract: The present invention relates to epothilon derivatives and to their use.
    Type: Application
    Filed: April 16, 2001
    Publication date: October 25, 2001
    Inventors: Gerhard Hoefle, Michael Kiffe
  • Epothilons C and D, preparation and compositions
    Patent number: 6288237
    Abstract: The present invention relates to epothilon derivatives and to their use.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: September 11, 2001
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Gerhard Hoefle, Michael Kiffe
  • Method for recovering optically pure amino acid derivatives
    Patent number: 5670647
    Abstract: A method for recovering an optically pure amino acid derivative from a waste liquor collected after a coupling reaction in peptide synthesis, comprising the steps of (a) adding into the waste liquor, in which an uncoupled amino acid derivative or an uncoupled small peptide fragment is contained, a compound selected from the group consisting of 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOObt) and N-hydroxy-5-norbornen-2,3-dicarboxylic acid imide(HONB); (b) concentrating the waste liquor obtained in step (a); (c) treating a residue obtained in step (b) with an acidic buffer solution containing a tertiary amine; and (d) extracting and purifying the uncoupled amino acid derivative or the uncoupled small peptide fragment under acidic conditions.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: September 23, 1997
    Assignee: Shimadzu Corporation
    Inventors: Kiyoshi Nokihara, Michael Kiffe