Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: Crosslinked polyether siloxane block copolymers are obtained by reacting an alpha-omega hydrogen siloxane with at least one higher-order hydrogen siloxane and at least one polyether in the presence of a hydrosilylation catalyst. These are described, and also use thereof as additives for producing polyurethane foams, particularly mechanically foamed polyurethane foams.

Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.

Abstract: The use of long-chain citric acid esters as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The use of surfactant formulations comprising long-chain alcohols as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The invention relates to a process for producing a porous polyurethane coatings, using a polyol ester as additives in an aqueous polymer dispersion, the process comprising the steps of a) providing a mixture comprising an aqueous polymer dispersion, a polyol ester, and an additive, b) foaming the mixture to give a homogeneous, fine-cell foam, c) adding at least one thickener to establish the desired viscosity of the wet foam, d) applying a coating of the foamed polymer dispersion to a suitable carrier, e) drying the coating. The invention further relates to a phosphorylated polyol ester.

Abstract: Amides of an aliphatic polyamine with two or three molecules of 12-hydroxyoctadecanoic acid, wherein the polyamine comprises at least one primary amino group for each molecule of 12-hydroxyoctadecanoic acid and additionally at least one secondary and/or tertiary amino group, can be used in a lipase stable thickener composition comprising from 50 to 95% by weight of one or more of the amides, from 5 to 50% by weight of one or more diluents and from 0 to 10% by weight water, and such thickener compositions can be prepared by a step of heating a starting mixture comprising hydrogenated castor oil and one or more aliphatic polyamines and adding one or more diluents before or after the heating step.

Abstract: The combined use of polyol esters and cationic polyelectrolytes as additives in cosurfactant-containing aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: Process for producing SiOC-bonded, linear polydialkylsiloxane-polyoxyalkylene block copolymers comprising repeating (AB) units comprising the reaction of a linear, ?,?-(SiH)-functional polydialkylsiloxane (a) with a linear ?,?-(OH)-functional polyoxyalkylene (b) using one or more compounds of elements of main group III and/or the 3rd transition group as catalyst (c), optionally in the presence of a solvent (d), wherein the two reactants (a) and (b) preferably in equimolar amounts and with controlled hydrogen evolution are reacted to quantitative SiH conversion.

Abstract: The use of polyamine- and/or polyalkanolamine-based carboxylic acid derivatives as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The combined use of polyol ethers and cationic polyelectrolytes as additives in cosurfactant-containing aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The joint use of polyol esters and ethylene oxide-rich alkyl alkoxylates as additives in filler-containing aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The joint use of polyol ethers and ethylene oxide-rich alkyl alkoxylates as additives in filler-containing aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: A process for preparing polyether-siloxane block copolymers by hydrosilylation of alpha,omega-modified hydrosiloxanes with alpha,omega-modified di(meth)allyl polyethers in the presence of a hydrosilylation catalyst, wherein the reaction is performed in a solvent mixture comprising aromatic solvents, polyethers and alkoxylated alcohol, is described.

Abstract: The use of surfactant formulations comprising long-chain alcohols as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The use of two-tail long-chain anionic surfactants as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The use of long-chain citric acid esters as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: The use of long-chain phosphoric acid esters as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: Disclosed herein is a method for producing polyurethane or polyisocyanurate foams. The method involves reacting a composition (Z1) with at least one polyisocyanate, and occurs in the presence of at least one nucleating agent and a blowing agent, in which the nucleating agent and the blowing agent are mixed to obtain a composition (Z2) that is added to the composition (Z1) before it is reacted with the at least one polyisocyanate. The composition (Z1) contains (i) 100 parts by mass of a composition (ZP) including at least one polyol and at least one catalyst that catalyzes formation of a urethane, urea or isocyanuarate bond, and (ii) from 0.05 to 10 parts by mass of a surfactant TD having an HLB value below 6 and no silicon atom.

Abstract: Crosslinked polyether siloxane block copolymers are obtained by reacting an alpha-omega hydrogen siloxane with at least one higher-order hydrogen siloxane and at least one polyether in the presence of a hydrosilylation catalyst. These are described, and also use thereof as additives for producing polyurethane foams, particularly mechanically foamed polyurethane foams.