Patents by Inventor Michael Knierman

Michael Knierman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240395525
    Abstract: In some examples, a three-dimensional printed nanospray interface for mass spectrometry may include a body including a sheath inlet connected to a sheath outlet for passage of sheath liquid to an emitter. The emitter may include a sidewall including a stepped texture on an inner surface of the sidewall.
    Type: Application
    Filed: May 23, 2023
    Publication date: November 28, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Michael KNIERMAN, Stephen ZANON
  • Publication number: 20060213258
    Abstract: A robotic system for handling components during chromatographic analysis of a sample includes a holder for positioning a sample within a separation pathway, the holder including a first opening having an internally tapered shape and a second opening having an externally tapered shape. An interior of the holder, between the first and second openings, defines the separation pathway. A hollow rigid member has an externally tapered shape, and a receiving portion has an internally tapered shape. The holder is positioned between the hollow rigid member and the receiving portion, wherein the externally tapered hollow rigid member engages the internally tapered first opening and the internally tapered receiving portion receives the externally tapered second opening to provide a sealed separation pathway extending from the hollow rigid member to the receiving portion.
    Type: Application
    Filed: March 24, 2006
    Publication date: September 28, 2006
    Inventors: John Hale, Michael Knierman, Kirk Boraas
  • Patent number: 7101968
    Abstract: The present invention relates generally to the field of analyzing proteins and more specifically to the reduction and alkylation of protein samples during protein analysis. A novel composition and method for reducing and alkylating proteins is disclosed. A novel reagent including a combination of a volatile reducing agent, a volatile alkylating agent, and a volatile solvent is used for a one-step reduction and alkylation of proteins allowing the protein sample to remain in the same container during the reduction and alkylation processes.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: September 5, 2006
    Assignee: Indiana Proteomics Consortium LLC
    Inventors: John Hale, Michael Knierman
  • Publication number: 20060167233
    Abstract: The present invention relates generally to the field of analyzing proteins and more specifically to the reduction and alkylation of protein samples during protein analysis. A novel composition and method for reducing and alkylating proteins is disclosed. A novel reagent including a combination of a volatile reducing agent, a volatile alkylating agent, and a volatile solvent is used for a one-step reduction and alkylation of proteins allowing the protein sample to remain in the same container during the reduction and alkylation processes.
    Type: Application
    Filed: September 9, 2005
    Publication date: July 27, 2006
    Inventors: John Hale, Michael Knierman
  • Publication number: 20040176579
    Abstract: The present invention relates generally to the field of analyzing proteins and more specifically to the reduction and alkylation of protein samples during protein analysis. A novel composition and method for reducing and alkylating proteins is disclosed. A novel reagent including a combination of a volatile reducing agent, a volatile alkylating agent, and a volatile solvent is used for a one-step reduction and alkylation of proteins allowing the protein sample to remain in the same container during the reduction and alkylation processes.
    Type: Application
    Filed: September 3, 2003
    Publication date: September 9, 2004
    Applicant: Indiana Proteomics Consortium, LLC
    Inventors: John Hale, Michael Knierman