Abstract: Provided herein are 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiophene-2-carboxamide and 4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)thiophene-2-carboxamide derivatives. Such compounds are useful, for example, for the treatment and/or prevention of neurodegenerative diseases or disorders such as ophthalmological neurodegenerative disorders. This disclosure also features compositions containing the same as well as methods of using and making the same.

Abstract: The invention relates to the transport of a load with a transport system comprising a first driven transport chassis and a second driven transport chassis, wherein in a first driving manoeuvre the second transport chassis follows the first transport chassis, wherein after the end of the first driving manoeuvre and switching to a second driving manoeuvre an alignment of the second transport chassis takes place, wherein after the alignment the load is transported with the transport system in the second driving manoeuvre, wherein in the second driving manoeuvre the second transport chassis follows the first transport chassis, wherein expediently at least one of the, preferably both, transport chassis can be freely positioned under the load.

Abstract: A plug-in summation current transformer module for insertion into a module-overlapping installation space of a multi-pole rail-mounted device that is formed of a plurality of housing modules has a summation current transformer and primary conductors routed through the tubular summation current transformer. The primary conductors have primary conductor ends. A primary conductor holder for fixing the primary conductor ends is fastened to the summation current transformer and adopts a fixing position for holding the primary conductor ends in an assembling position for insertion into a module-overlapping installation space and a releasing position where the primary conductor ends move transversely into a releasing position allowing the primary conductor ends to join into their contacts in the modules.

Abstract: The invention relates to: a method for monitoring a process engineering installation, in which a model of the process engineering installation is used to ascertain values of at least one performance parameter of the process engineering installation from actual values of at least one operating parameter of the process engineering installation that occur during operation of the process engineering installation, wherein the model is used to ascertain comparison values of the at least one performance parameter of the process engineering installation from setpoint values of the at least one operating parameter, and wherein mutually corresponding values and comparison values of the at least one performance parameter are taken as a basis for ascertaining at least one performance gap in the operation of the process engineering installation and to a process engineering installation.

Abstract: A latch module has an insertion mouth for receiving a closing member on closing of a door of a domestic appliance. Two collar portions which project away from one another are formed on both sides of the insertion mouth. Beneath a first of the collar portions there is formed a first recess, and beneath the second of the collar portions there is formed a second recess, which in some exemplary embodiments has two steps, where a first, less deep step is formed by a first lateral wall sub-portion and a second, deeper step is formed by a second lateral wall sub-portion.

Abstract: A plug-in summation current transformer module for insertion into a module-overlapping installation space of a multi-pole rail-mounted device that is formed of a plurality of housing modules has a summation current transformer and primary conductors routed through the tubular summation current transformer. The primary conductors have primary conductor ends. A primary conductor holder for fixing the primary conductor ends is fastened to the summation current transformer and adopts a fixing position for holding the primary conductor ends in an assembling position for insertion into a module-overlapping installation space and a releasing position where the primary conductor ends move transversely into a releasing position allowing the primary conductor ends to join into their contacts in the modules.

Abstract: A base module of an electronic device is adapted to provide a basic functionality, wherein the base module comprises a connection device for electrically contacting the base module, and wherein the connection device is adapted to establish an electrical connection between the base module and an extension module for functional extension of the base module, so that the base module may be electrically contacted through the extension module. Furthermore, an extension module and an electronic device with extended functionality are proposed.

Abstract: A disclosed method of detecting and terminating a source of toxic gas emission includes: detecting a gas concentration level in a zone exceeding a threshold; calculating a time weighted average gas concentration level within the zone; determining that the gas concentration level in the zone has exceeded the time weighted average gas concentration; and disabling a gas emitting source in response to determining that the gas concentration level in the zone has exceeded the time weighted average gas concentration.

Abstract: Provided herein are 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiophene-2-carboxamide and 4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)thiophene-2-carboxamide derivatives. Such compounds are useful, for example, for the treatment and/or prevention of neurodegenerative diseases or disorders such as ophthalmological neurodegenerative disorders. This disclosure also features compositions containing the same as well as methods of using and making the same.

Abstract: A spotlight system for illuminating a film or stage environment comprises a spotlight for generating light; and at least one optical component couplable to the spotlight for producing at least one spatial light distribution, wherein the optical component and/or the spotlight has/have a memory in which information on the spatial light distribution producible by the optical component is stored.

Abstract: Provided herein are 2-amino-pyrazolyl-[1,2,4]triazolo [1,5a]pyridine derivatives. Such compounds are useful, for example, for the treatment and/or prevention of neurodegenerative diseases or disorders such as ophthalmological neurodegenerative disorders. This disclosure also features compositions containing the same as well as methods of using and making the same.

Abstract: The present invention relates to a method of producing fatty acid alkyl ester from an organic oil source containing at least one free fatty acid, wherein the oil source has an acid number of at least 30 mg KOH/g oil source and wherein the method comprises the steps of a) reacting the oil source with glycerol at a temperature, which does not exceed 180° C. during the reaction, in the presence of a catalyst comprising at least one alkyl or aryl sulfonic acid or an homoanhydride thereof; and b) transesterification of the reaction product from step a) with an alkanol; and c) isolating the fatty acid alkyl ester from the reaction product of step b).

Abstract: A machine arrangement sequentially processes sheet-like substrates with multiple different processing stations each having a substrate-guiding unit and a substrate-processing unit. At least one of the processing stations has, as a substrate-processing unit, at least one non-impact printing device which prints on the substrate. The processing station with the at least one non-impact printing device has a printing cylinder. Each non-impact printing device is arranged at the circumference of the printing cylinder. The printing cylinder is triple-sized or quadruple-sized. A double-sized or a triple-sized transfer drum, or a corresponding feed cylinder, is arranged directly upstream of this printing cylinder. Alternatively, a double-sized or a triple-sized transfer drum, or a corresponding transfer cylinder, is arranged directly downstream of this printing cylinder.

Abstract: A method for operating a circuit breaker includes: initiating a shutdown process when a fault current caused by body contact or ground contact is detected; and during the shutdown process, reducing a voltage value between a neutral conductor and at least one current-carrying conductor at an output of the circuit breaker to substantially zero from an operating-voltage value according to a predetermined shutdown curve by a shutdown unit. During the shutdown process, the circuit is not suddenly interrupted, but the voltage value is reduced from a starting point according to the shutdown curve and only reaches substantially zero after a predetermined first time period.

Abstract: The invention relates to: a method for monitoring a process engineering installation, in which a model of the process engineering installation is used to ascertain values of at least one performance parameter of the process engineering installation from actual values of at least one operating parameter of the process engineering installation that occur during operation of the process engineering installation, wherein the model is used to ascertain comparison values of the at least one performance parameter of the process engineering installation from setpoint values of the at least one operating parameter, and wherein mutually corresponding values and comparison values of the at least one performance parameter are taken as a basis for ascertaining at least one performance gap in the operation of the process engineering installation and to a process engineering installation.

Abstract: A machine arrangement, for sequentially processing sheet-type substrates, includes a plurality of different processing stations, one of which includes a non-impact printing device that prints the substrates. The processing station, including the non-impact printing device, also includes a printing cylinder, on the circumference of which, the non-impact printing device that prints the substrates is arranged. On the circumferential surface of the printing cylinder, four substrates are or can be placed behind each other in the circumferential direction. Each of the substrates that are to be conveyed are retained in one of a force-locking and a form-fitting manner on the circumferential surface of the printing cylinder by at least one retaining element.

Abstract: Disclosed aspects relate to a clock distribution network of a synchronous logic device. The synchronous logic device has sub-circuits having different clock domains. The clock domains form a hierarchical structure. The clock distribution network has a clock source to provide a global clock signal. A programmable delay line associated with a sub-circuit generates a local clock signal for the sub-circuit by delaying the signal. A global skew control circuit can manage clock skew between the local clock signals. The global skew control circuit may adjust a delay, determine initial operations for the delay lines, verify whether it is possible to perform the initial operations, and perform a correction operation. The correction operation can include correcting the control commands such that the corrected commands lead to the same change of skew adjustment between the local clocks.

Abstract: The present invention relates to a method of producing fatty acid alkyl ester from an organic oil source containing at least one free fatty acid, wherein the oil source has an acid number of at least 30 mg KOH/g oil source and wherein the method comprises the steps of a) reacting the oil source with glycerol at a temperature, which does not exceed 180° C. during the reaction, in the presence of a catalyst comprising at least one alkyl or aryl sulfonic acid or an homoanhydride thereof; and b) transesterification of the reaction product from step a) with an alkanol; and c) isolating the fatty acid alkyl ester from the reaction product of step b).

Abstract: A spotlight system for illuminating a film or stage environment comprises a spotlight for generating light; and at least one optical component couplable to the spotlight for producing at least one spatial light distribution, wherein the optical component and/or the spotlight has/have a memory in which information on the spatial light distribution producible by the optical component is stored.