Patents by Inventor Michael Kocks
Michael Kocks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10376663Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.Type: GrantFiled: November 16, 2012Date of Patent: August 13, 2019Assignee: St. Michael's HospitalInventors: Christer Sinderby, Norman Comtois, Jennifer Beck, Pär Emtell, Michael Kock
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Publication number: 20160010067Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.Type: ApplicationFiled: June 5, 2015Publication date: January 14, 2016Inventors: Michael Kock, Thomas HöGER, Burkhard Kröger, Bernd Otterbach, Wilfried Lubisch, Hans-Georg Lemaire
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Publication number: 20150368663Abstract: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.Type: ApplicationFiled: August 10, 2015Publication date: December 24, 2015Inventors: Hee-Sook Song, Michael Kock, Jeffrey A. Brown, Linda Patricia Loyall, Liqun Xing, Hongmei Jia, John McMillan, Lesley Ireland
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Patent number: 9133466Abstract: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.Type: GrantFiled: May 15, 2013Date of Patent: September 15, 2015Assignee: BASF Plant Science GmbHInventors: Hee-Sook Song, Michael Kock, Jeffrey A. Brown, Linda Patricia Loyall, Liqun Xing, Hongmei Jia, John McMillan, Lesley Ireland
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Patent number: 9051553Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.Type: GrantFiled: May 12, 2010Date of Patent: June 9, 2015Assignee: AbbVie Deutschland GmbH & Co. KGInventors: Michael Kock, Thomas Höger, Burkhard Kröger, Bernd Otterbach, Wilfried Lubisch, Hans-Georg Lemaire
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Publication number: 20140296728Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.Type: ApplicationFiled: November 16, 2012Publication date: October 2, 2014Inventors: Christer Sinderby, Norman Comtois, Jennifer Beck, Pär Emtell, Michael Kock
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Publication number: 20130236954Abstract: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.Type: ApplicationFiled: May 15, 2013Publication date: September 12, 2013Applicant: BASF Plant Science GmbHInventors: Hee-Sook Song, Michael Kock, Jeffrey A. Brown, Linda Patricia Loyall, Liqun Xing, Hongmei Jia, John McMillan, Lesley Ireland
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Patent number: 8465915Abstract: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by the methods isolated from rice.Type: GrantFiled: July 30, 2005Date of Patent: June 18, 2013Assignee: BASF Plant Science GmbHInventors: Hee-Sook Song, Michael Kock, Jeffrey A. Brown, Linda Patricia Loyall, Liqun Xing, Hongmei Jia, John McMillan, Lesley Ireland
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Publication number: 20110295712Abstract: The present invention is directed to a computer-implemented method, system and apparatus to enable data-driven, multi-channel communications to facilitate business processes. By providing more than one channel for communication between market participants, which includes suppliers and consumers, real-time requests for information, services, or the like can be solicited in a way that those selected to provide responses have certain attributes, and the supplier is selected for the solicitation automatically and instantaneously notified of the request based on automatic selection of those attributes. The notification is instantaneously communicated using more than one channel of communication, potentially in a mode that the potential supplier has indicated is a more likely way of actually and instantly receiving the request. The system further provides at least one mechanism by which all of the selected suppliers can instantly respond to the request, which is then communicated to the requestor.Type: ApplicationFiled: November 3, 2009Publication date: December 1, 2011Applicant: TARGETED INSTANT COMMUNICATIONS, INC.Inventors: Matthew Dennis Browning, Derek Michael Kock
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Publication number: 20110107444Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.Type: ApplicationFiled: May 12, 2010Publication date: May 5, 2011Inventors: MICHAEL KOCK, THOMAS HÖGER, BURKHARD KRÖGER, BERND OTTERBACH, WILFRIED LUBISCH, HANS-GEORG LEMAIRE
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Patent number: 7786344Abstract: The present invention relates to processes for preparing transformed plant cells or organisms by transforming a population of plant cells which comprises at least one marker protein having a direct or indirect toxic effect for said population, with at least one nucleic acid sequence to be inserted in combination with at least one compound, preferably a DNA construct, capable of reducing the expression, amount, activity and/or function of the marker protein, with the transformed plant cells having a growth advantage over nontransformed cells, due to the action of said compound.Type: GrantFiled: July 18, 2003Date of Patent: August 31, 2010Assignee: BASF Plant Science GmbHInventors: Michael Kock, Markus Frank, Ralf Badur
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Patent number: 7781596Abstract: The invention relates to novel 2-phenylbenzimidazoles of general formula (I) or (II), wherein the radicals have the meanings cited in the description, and to their tautomeric forms, possible enantiomeric and diastereomeric forms, to their prodrugs, and to possible physiologically compatible salts. The invention also relates to the production of said compounds and to their use.Type: GrantFiled: October 28, 1999Date of Patent: August 24, 2010Assignee: Abbott LaboratoriesInventors: Wilfried Lubisch, Michael Kock, Thomas Höger
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Publication number: 20100192264Abstract: The present invention relates to processes for preparing transformed plant cells or organisms by transforming a population of plant cells which comprises at least one marker protein having a direct or indirect toxic effect for the population, with at least one nucleic acid sequence to be inserted in combination with at least one compound, preferably a DNA construct, capable of reducing the expression, amount, activity and/or function of the marker protein, with the transformed plant cells having a growth advantage over nontransformed cells, due to the action of the compound.Type: ApplicationFiled: February 1, 2010Publication date: July 29, 2010Applicant: BASF Plant Sciences GmbHInventors: Michael Kock, Markus Frank, Ralf Badur
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Patent number: 7754459Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C ?in which ?m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.Type: GrantFiled: June 4, 1999Date of Patent: July 13, 2010Assignee: BASF AktiengesellschaftInventors: Michael Kock, Thomas Höger, Burkhard Kröger, Bernd Otterbach, Wilfried Lubisch, Hans-Georg Lemaire
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Publication number: 20070243543Abstract: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.Type: ApplicationFiled: July 30, 2005Publication date: October 18, 2007Applicant: BASF Plant Science GmbHInventors: Hee-Sook Song, Michael Kock, Jeffrey Brown, Linda Loyall, Liqun Xing, Hongmei Jia, John McMillan, Lesley Ireland
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Publication number: 20060218658Abstract: The present invention relates to processes for preparing transformed plant cells or organisms by transforming a population of plant cells which comprises at least one marker protein having a direct or indirect toxic effect for said population, with at least one nucleic acid sequence to be inserted in combination with at least one compound, preferably a DNA construct, capable of reducing the expression, amount, activity and/or function of the marker protein, with the transformed plant cells having a growth advantage over nontransformed cells, due to the action of said compound.Type: ApplicationFiled: July 18, 2003Publication date: September 28, 2006Applicant: BASF Plant Science GmbHInventors: Michael Kock, Markus Frank, Ralf Badur
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Patent number: 7087637Abstract: The present invention relates to novel indole derivatives, to their preparation and to their use, as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), for producing drugs.Type: GrantFiled: May 9, 2001Date of Patent: August 8, 2006Assignee: BASF AGInventors: Roland Grandel, Wilfried Lubisch, Michael Kock, Thomas Hoger, Reinhold Muller, Sabine Schult, Uta Holzenkamp
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Patent number: 7041675Abstract: The invention relates to compounds of the formula I and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.Type: GrantFiled: January 25, 2001Date of Patent: May 9, 2006Assignee: Abbott GmbH & Co. KGInventors: Wilfried Lubisch, Michael Kock, Thomas Hoeger, Roland Grandel, Reinhold Mueller, Sabine Schult
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Publication number: 20050260754Abstract: The present invention relates to constructs and methods for regulating the gene expression of at least two endogenous target genes by introducing, into a eukaryotic cell or a eukaryotic organism, an at least partially double-stranded ribonucleic acid molecule, the ribonucleic acid molecule comprising at least two ribonucleotide sequence segments which are homologous to various genes of the eukaryotic cell.Type: ApplicationFiled: March 17, 2003Publication date: November 24, 2005Inventors: Michael Kock, Jorg Bauer
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Patent number: RE39608Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.Type: GrantFiled: November 23, 1999Date of Patent: May 1, 2007Assignee: Abbott GmbH & Co. KGInventors: Wilfried Lubisch, Michael Kock, Thomas Höger, Sabine Schult, Roland Grandel, Reinhold Müller